Adrenomedullin increases cyclic AMP more potently than CGRP and amylin in rat renal tubular basolateral membranes

Osajima, Akihiko; Mutoh, Yoshinobu; Uezono, Yasuhito; Kawamura, Masaru; Izumi, Fujio; Takasugi, Masayuki; Kuroiwa, Akio

doi:10.1016/0024-3205(95)00279-f

Cited by 29 publications

(13 citation statements)

References 17 publications

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“…Osajima et al [26] showed that AM increased the cyclic adenosine monophosphate level in rat renal tubular basolateral membrane and suggested that AM modulates the renal tubular functions. Intrarenal infusion of AM has been shown to produce a marked diuretic and natriuretic response in dogs [6, 7], associated with an increase in glomerular filtration rate and fractional sodium excretion and a decrease in distal tubular sodium reabsorption.…”

Section: Discussionmentioning

confidence: 99%

Measurement of Plasma and Urinary Adrenomedullin in Patients with IgA Nephropathy

Kubo

Iwano

Minamino

et al. 1998

Nephron

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In this study, we measured plasma and urinary adrenomedullin (AM) concentrations in 47 patients with IgA nephropathy. Controls were 39 healthy volunteers. Plasma and urinary AM values were measured by specific radioimmunoassay. The plasma AM concentrations were higher, and the urinary AM levels were lower in patients with IgA nephropathy than in healthy volunteers. Plasma AM concentrations showed a positive correlation with serum creatinine and blood urea nitrogen, whereas urinary AM levels correlated negatively with serum creatinine and blood urea nitrogen. The plasma AM concentrations showed a positive correlation with fractional excretions of sodium and potassium. Renal biopsy specimens of patients without renal failure were scored for activity (percentage of glomeruli demonstrating cellular crescent formation, degree of mesangial proliferation and interstitial infiltration; total score = 9). Urinary AM levels were shown to be lower in the group with a high activity (score 3–9) as compared with the group with a low activity (score 0–2) based on renal biopsy. Thus, urinary levels of AM are affected by the degree of the activity in IgA nephropathy, and AM may participate in the pathophysiology of IgA nephropathy.

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Section: Discussionmentioning

confidence: 99%

Measurement of Plasma and Urinary Adrenomedullin in Patients with IgA Nephropathy

Kubo

Iwano

Minamino

et al. 1998

Nephron

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“…AM increases cAMP more potently than CGRP and amylin in rat renal tubular basolateral membranes, 14 indicating that renal tubules may be one of the target cells for AM. The intravenous infusion of AM exerted diuresis and natriuresis due to the increased glomerular filtration rate and effective renal plasma flow.…”

Section: Yoshihara Et Al Renal Adrenomedullin In Heart Failure 219mentioning

confidence: 99%

“…[5][6][7][8][9] Furthermore, AM has been shown to inhibit DNA synthesis 10,11 and endothelin production 12 and to stimulate cAMP formation 13 in mesangial cells and renal tubular cells. 14,15 These findings suggest that AM may elicit its action as an autocrine and/or a paracrine factor as well as a circulating factor in the kidney. However, the specific AM receptor that mediates these many AM functions was only recently elucidated.…”

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confidence: 93%

Alterations of Intrarenal Adrenomedullin and Its Receptor System in Heart Failure Rats

et al. 2001

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Abstract-Calcitonin receptor-like receptor/receptor activity-modifying protein 2 (CRLR/RAMP2) and CRLR/RAMP3 complexes have been reported to be specific adrenomedullin (AM) receptors. In the present study, we evaluated the pathophysiological significance of renal AM and its receptor system in aortocaval shunt (ACS) rats. Renal AM levels were measured serially during 5 weeks after the operation. Renal gene expressions of AM, CRLR, RAMP2, and RAMP3 were measured at 2 weeks (decompensated phase) and 5 weeks (compensated phase) after the operation. Immunohistochemical localizations of renal AM were also evaluated. Furthermore, the relations between urinary sodium excretion (UNaV) and renal AM levels were evaluated. Renal AM levels were higher in ACS than in control animals only at 1, 2, and 3 weeks after the operation. At 2 weeks after the operation, renal AM mRNA expression was also higher in ACS than in control animals. CRLR, RAMP2, and RAMP3 mRNAs were expressed in the kidney, but there were no differences between the 2 groups. Immunohistochemistry revealed the positive AM immunostaining within the renal tubular cells, and it was more intense in ACS than in control animals. There were significant correlations between UNaV and renal AM levels. At 5 weeks after the operation, there were no differences in mRNA levels of AM, CRLR, RAMP2, and RAMP3 between the 2 groups. There was a significant correlation between UNaV and medullary AM levels. The present findings suggest that increased renal AM levels in decompensated heart failure, presumably due to increased AM production in renal tubules, in part, are involved in the regulation of sodium excretion. Key Words: adrenomedullin Ⅲ receptors, adrenomedullin Ⅲ kidney Ⅲ heart failure Ⅲ sodium A drenomedullin (AM) and its gene expression have been reported to be observed in the glomerulus, distal tubules, and medullary collecting duct cells with respect to limitation to the kidney. [1][2][3][4] The AM infusion studies revealed that AM increased renal blood flow, urine flow, and urinary sodium excretion (UNaV) and decreased proximal and distal fractional reabsorption of sodium. 5-9 Furthermore, AM has been shown to inhibit DNA synthesis 10,11 and endothelin production 12 and to stimulate cAMP formation 13 in mesangial cells and renal tubular cells. 14,15 These findings suggest that AM may elicit its action as an autocrine and/or a paracrine factor as well as a circulating factor in the kidney. However, the specific AM receptor that mediates these many AM functions was only recently elucidated. McLatchie et al 16 demonstrated that the calcitonin receptor-like receptor (CRLR), a receptor with 7 transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an AM receptor, depending on which members of a new family of single-transmembrane-domain proteins, which are called receptor-activity-modifying proteins (RAMPs) are expressed. RAMP1 presents the receptor at the cell surface as a CGRP receptor, whereas RAMP2-or RAMP3-transported receptors ...

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“…The receptors sensitive to AM were preferentially expressed in renal tubular basolateral membranes [70]. A dose of 10 –7 M AM stimulated cAMP generation in glomerulus >> cortical collecting duct = inner medullary collecting duct > outer medullary collecting duct, but not in proximal convoluted tubule or medullary thick ascending limb.…”

Section: Biological Features Of Am In the Kidneymentioning

confidence: 99%

Adrenomedullin and Its Role in Renal Diseases

Eto¹,

Kïtamura²

2001

Nephron

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Adrenomedullin increases cyclic AMP more potently than CGRP and amylin in rat renal tubular basolateral membranes

Cited by 29 publications

References 17 publications

Measurement of Plasma and Urinary Adrenomedullin in Patients with IgA Nephropathy

Measurement of Plasma and Urinary Adrenomedullin in Patients with IgA Nephropathy

Alterations of Intrarenal Adrenomedullin and Its Receptor System in Heart Failure Rats

Adrenomedullin and Its Role in Renal Diseases

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