Adrenomedullin and Its Role in Renal Diseases

Eto, Tanenao; Kïtamura, Kazuo

doi:10.1159/000046059

Cited by 17 publications

(24 citation statements)

References 71 publications

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“…In the kidney, adrenomedullin is expressed in glomeruli, tubuli, and collecting ducts. It is thought to be antiproliferative, proapoptotic, and antifibrotic (13). In previous studies, adrenomedullin mRNA and protein expression were upregulated during the resolution phase of antiThy1GN (37).…”

Section: Discussionmentioning

confidence: 93%

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Genetic predisposition for glomerulonephritis-induced glomerulosclerosis in rats is linked to chromosome 1

IJpelaar

Schulz

Aben

et al. 2008

Physiological Genomics

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Section: Discussionmentioning

confidence: 93%

“…However, Rab38 was not linked to development of glomerulosclerosis in an (FHHxACI) F2 intercross (54). Adrenomedullin is a potent vasodilative peptide (13). In the kidney, adrenomedullin is expressed in glomeruli, tubuli, and collecting ducts.…”

Section: Discussionmentioning

confidence: 99%

Genetic predisposition for glomerulonephritis-induced glomerulosclerosis in rats is linked to chromosome 1

IJpelaar

Schulz

Aben

et al. 2008

Physiological Genomics

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“…The urinary excretion of AM, probably derived from the kidney, but not from the blood stream, is negatively correlated with urinary protein excretion and the severity of glomerular lesions [26,27,28]. Immunohistochemical studies performed by Kuo et al [29] show that the glomerular production of AM is decreased in IgA nephropathy patients without impaired renal function.…”

Section: Discussionmentioning

confidence: 99%

Increased Production of Adrenomedullin in Glomeruli from Anti-Glomerular Basement Membrane Glomerulonephritis Rats Treated with Methylprednisolone

Iwatsubo¹,

Fujimoto²,

Matsumoto³

et al. 2006

Nephron Exp Nephrol

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Background/Aims: Adrenomedullin (AM) has anti-proliferative and apoptotic effects on mesangial cells (MCs). Both effects play an important role in the progression of glomerulonephritis (GN). Glucocorticoids are widely used for the treatment of GN; however, the relationship between AM regulation in MCs or glomeruli and glucocorticoid treatment has not been clarified. Methods: Using the cultured rat MCs, AM secretion induced by methylprednisolone (m-PSL), and MC proliferation and apoptosis caused by AM were examined. In addition, the role of AM receptor antagonist, AM(22-52), was also investigated. Then, we made an anti-glomerular basement membrane (GBM) GN rat model and compared the AM expression and production in each glomeruli obtained from the control or m-PSL-treated anti-GBM GN rats. Results: In the cultured rat MCs, AM secretion was increased by m-PSL. MC proliferation was inhibited, while MC apoptosis was increased by AM. MC apoptosis was inhibited by the addition of AM(22-52). M-PSL therapy ameliorated the progression of anti-GBM GN rats. AM expression and production were increased in the glomeruli from m-PSL-treated rats compared to the controls. Conclusion: Considering the anti-proliferative and apoptotic effects of AM on MCs, increased AM in the glomeruli might participate in the improvement of glomerular lesions in anti-GBM GN rats treated with m-PSL.

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“…Adrenomedullin (ADM), a 52 amino acid peptide originally isolated from human phaeochromocytoma, is a potent vasodilator and is expressed in various organs throughout the body where it exerts systemic and local effects [1,2]. In the kidney, ADM is produced in glomerular endothelial cells, vascular smooth muscle cells, distal and collecting tubules and mesangial cells [1].…”

Section: Introductionmentioning

confidence: 99%

“…In the kidney, ADM is produced in glomerular endothelial cells, vascular smooth muscle cells, distal and collecting tubules and mesangial cells [1]. In most cell types, ADM acts via a G-protein-coupled receptor named calcitonin receptor-like receptor (CLR).…”

Section: Introductionmentioning

confidence: 99%

Effects of Adrenomedullin on the Glomerular Adrenomedullin System in a Rat Model of Anti-Thy1 Glomerulonephritis

Geissler¹,

Plank²,

Hartner³

et al. 2010

Nephron Exp Nephrol

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Background: Adrenomedullin (ADM) has antiproliferative effects on glomerular mesangial cells. The study was performed to determine changes in glomerular gene expression of the ADM system by ADM treatment in anti-Thy1 glomerulonephritis (GN). Methods: GN in rats was induced by injecting anti-Thy-1 antibody. To show the effect of ADM treatment, rats received ADM from day 3 to day 6 of GN. Supplemental rats were sacrificed on day 3, 7 and 14 of GN to show the expression pattern of adrenomedullin and its receptors. Glomeruli were prepared by sieving or laser-assisted microdissection. Expression of ADM, calcitonin receptor-like receptor (CLR), receptor activity-modifying proteins (RAMP) 1–3, CD34, Thy1 and nephrin was analyzed using real-time PCR. Results: During GN a reduction of CLR and RAMP 2 + 3 expressions was detected on days 3, 7 and 14, while RAMP 1 rose. ADM mRNA decreased on days 3 and 7. Thy1 expression as a surrogate of mesangial cell number was downregulated during GN. A significant reduction of CD34 expression, as a surrogate for endothelial cell number, was detected on day 7. A tendency towards reduction of nephrin gene expression, as a surrogate for number of podocytes, was seen. The administration of ADM during GN did not change the expression on Thy1, CD34 or nephrin. The results were similar for microdissected and sieved glomeruli. In ADM-treated GN animals ADM gene expression rose compared to untreated GN animals on day 6. These effects were detected both in sieved and microdissected glomeruli. ADM administration did not change the expression of the receptors. Conclusion: The downregulation of adrenomedullin during GN at the gene level can be improved by ADM application.

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Adrenomedullin and Its Role in Renal Diseases

Cited by 17 publications

References 71 publications

Genetic predisposition for glomerulonephritis-induced glomerulosclerosis in rats is linked to chromosome 1

Genetic predisposition for glomerulonephritis-induced glomerulosclerosis in rats is linked to chromosome 1

Increased Production of Adrenomedullin in Glomeruli from Anti-Glomerular Basement Membrane Glomerulonephritis Rats Treated with Methylprednisolone

Effects of Adrenomedullin on the Glomerular Adrenomedullin System in a Rat Model of Anti-Thy1 Glomerulonephritis

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