Adrenaline Facilitates Synaptic Transmission by Synchronizing Release of Acetylcholine Quanta from Motor Nerve Endings

Khuzakhmetova, Venera; Bukharaeva, É. A.

doi:10.1007/s10571-020-00840-3

Cited by 8 publications

(2 citation statements)

References 40 publications

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“…Our experiments on the rat soleus NMJ showed that noradrenaline did not change the number of released quanta in response to nerve stimulation. However, adrenaline at the same concentration increased evoked ACh quantal release [ 43 ]. At the diaphragm NMJ of mice in low extracellular Ca 2+ , the activation of α1-adrenoceptors by phenylephrine did not change the EPP quantal content.…”

Section: Sympathomimetic Effects On Ach Quantal Release Evoked By the Nerve Stimulusmentioning

confidence: 99%

“…Recently, we investigated the effects of adrenergic drugs on the kinetics of ACh quantal release at mammal NMJs. In our experiments, adrenaline increased spontaneous and evoked quantal ACh release at the NMJ of the hindlimb soleus muscle and synchronized evoked ACh quantal secretion [ 43 ]. We suggested that the facilitation of the synaptic transmission by adrenaline is due to the increased Ca 2+ entering the axoplasm.…”

Section: Sympathomimetic Effects On Ach Quantal Release Evoked By the Nerve Stimulusmentioning

confidence: 99%

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Adrenoceptors Modulate Cholinergic Synaptic Transmission at the Neuromuscular Junction

Bukharaeva

Khuzakhmetova

Dmitrieva

et al. 2021

IJMS

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Adrenoceptor activators and blockers are widely used clinically for the treatment of cardiovascular and pulmonary disorders. More recently, adrenergic agents have also been used to treat neurodegenerative diseases. Recent studies indicate a location of sympathetic varicosities in close proximity to neuromuscular junctions. The pressing question is whether there could be any effects of endo- or exogenous catecholamines on cholinergic neuromuscular transmission. It was shown that the pharmacological stimulation of adrenoceptors, as well as sympathectomy, can affect both acetylcholine release from motor nerve terminals and the functioning of postsynaptic acetylcholine receptors. In this review, we discuss the recent data regarding the effects of adrenergic drugs on neurotransmission at the neuromuscular junction. The elucidation of the molecular mechanisms by which the clinically relevant adrenomimetics and adrenoblockers regulate quantal acetylcholine release from the presynaptic nerve terminals and postsynaptic sensitivity may help in the design of highly effective and well-tolerated sympathomimetics for treating a number of neurodegenerative diseases accompanied by synaptic defects.

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Section: Sympathomimetic Effects On Ach Quantal Release Evoked By the Nerve Stimulusmentioning

confidence: 99%

Section: Sympathomimetic Effects On Ach Quantal Release Evoked By the Nerve Stimulusmentioning

confidence: 99%

Adrenoceptors Modulate Cholinergic Synaptic Transmission at the Neuromuscular Junction

Bukharaeva

Khuzakhmetova

Dmitrieva

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

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Fabrication and theoretical analysis of sodium alpha-olefin sulfonate-anchored carbon paste electrode for the simultaneous detection of adrenaline and paracetamol

et al. 2022

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Sympathetic innervation in skeletal muscle and its role at the neuromuscular junction

Rudolf,

Kettelhut,

Navegantes

2024

J Muscle Res Cell Motil

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Neuromuscular junctions are the synapses between motor neurons and skeletal muscle fibers, which mediate voluntary muscle movement. Since neuromuscular junctions are also tightly associated with the capping function of terminal Schwann cells, these synapses have been classically regarded as tripartite chemical synapses. Although evidences from sympathetic innervation of neuromuscular junctions was described approximately a century ago, the essential presence and functional relevance of sympathetic contribution to the maintenance and modulation of neuromuscular junctions was demonstrated only recently. These findings shed light on the pathophysiology of different clinical conditions and can optimize surgical and clinical treatment modalities for skeletal muscle disorders.

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Adrenaline Facilitates Synaptic Transmission by Synchronizing Release of Acetylcholine Quanta from Motor Nerve Endings

Cited by 8 publications

References 40 publications

Adrenoceptors Modulate Cholinergic Synaptic Transmission at the Neuromuscular Junction

Adrenoceptors Modulate Cholinergic Synaptic Transmission at the Neuromuscular Junction

Fabrication and theoretical analysis of sodium alpha-olefin sulfonate-anchored carbon paste electrode for the simultaneous detection of adrenaline and paracetamol

Sympathetic innervation in skeletal muscle and its role at the neuromuscular junction

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