Adrenaline: communication by electron emission. Effect of concentration and temperature. Product analysis

Getoff, N.; Huber, Claudia; Hartmann, Johannes; Huber, Johannes; Quint, Ruth

doi:10.1515/hmbci.2010.028

Cited by 5 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The electron emissions of dopamine (DA) [19] , adrenaline (ADR) [20] , as well as genistein [12] are representative of the phytohormone group mentioned above. Some results are presented in Table 6 , which demonstrate the Q(e aq − ) decrease with a substrate increase as the consequence of ' associate ' formation.…”

Section: Electron Emission Of Water Soluble Hormonesmentioning

confidence: 99%

See 1 more Smart Citation

Hormones: electron emission, communication, mutual interaction, regeneration, metabolites, carcinogenesis and receptor action

Getoff¹

2012

Hormone Molecular Biology and Clinical Investigation

Self Cite

View full text Add to dashboard Cite

This review discusses the highlights of the recently made discovery about the ability of hormones to eject 'solvated electrons' (eaq-) in water containing media. The resulting consequences for communication with other biological systems by the electron-transfer process, formation of metabolites, the possible initiation of cancer, hormone regeneration and the action of hormone-receptor systems are briefly discussed. The molecular structure of the hormones and the environment are hereby found to be the most important determining factors for the yield of ejected eaq-. Furthermore, the hormone transients, which result from emission of eaq-, are reviewed, as well as the formation of metabolites, which can be involved in various biological processes. The hormone-transients can also be regenerated by electron-transfer from a potent electron donor, at least partly, as long as they are in a 'status nascendi state'. The discussion of all these effects is supported by corresponding experimental data and experiments in vitro. This review presents a complete new conception of the action mechanisms of hormones.

show abstract

Section: Electron Emission Of Water Soluble Hormonesmentioning

confidence: 99%

“…Representatives of this group of hormones were discussed in previous reports: DA [19] and ADR [20] . As their molecular structure is differentiated only by their side chains, the e aq − emission mechanism of ADR is reviewed as an example.…”

Section: Water Soluble Hormonesmentioning

confidence: 99%

Hormones: electron emission, communication, mutual interaction, regeneration, metabolites, carcinogenesis and receptor action

Getoff¹

2012

Hormone Molecular Biology and Clinical Investigation

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has been established on a number of steroid hormones ( Gerschpacher et al, 2010; Getoff et al, 2008, 2009a, 2010a, 2010b, 2010c, 2010d, 2010e ) and on phyto-hormone genistein ( Getoff et al, 2009b ) that hormones in a polar media containing water are able to emit electrons when excited in their singlet state. Above all, the electron yield depends not only on the molecular structure and concentration of the hormone, but also on the polarity and the pH of the media, temperature, energy input, etc.…”

Section: Introductionmentioning

confidence: 99%

Photo-induced regeneration of hormones by electron transfer processes: Potential biological and medical consequences

Getoff

Hartmann

Schittl

et al. 2011

Radiation Physics and Chemistry

Self Cite

View full text Add to dashboard Cite

Based on the previous results concerning electron transfer processes in biological substances, it was of interest to investigate if hormone transients resulting by e.g. electron emission can be regenerated.The presented results prove for the first time that the hormone transients originating by the electron emission process can be successfully regenerated by the transfer of electrons from a potent electron donor, such as vitamin C (VitC). Investigations were performed using progesterone (PRG), testosterone (TES) and estrone (E1) as representatives of hormones. By irradiation with monochromatic UV light (λ=254 nm) in a media of 40% water and 60% ethanol, the degradation as well as the regeneration of the hormones was studied with each hormone individually and in the mixture with VitC as a function of the absorbed UV dose, using HPLC. Calculated from the obtained initial yields, the determined regeneration of PRG amounted to 52.7%, for TES to 58.6% and for E1 to 90.9%. The consumption of VitC was determined in the same way.The reported results concerning the regeneration of hormones by the transfer of electrons from an electron donor offer a new, promising method for the therapy with hormones. As a consequence of the regeneration of hormones, a decreased formation of carcinogenic metabolites is expected.

show abstract

Method for regeneration of hormones: 17β-estradiol, 21α-hydroxyprogesterone and corticosterone. A pathway for a possible medical application

Getoff¹,

Brenn²,

Hartmann³

et al. 2011

Hormone Molecular Biology and Clinical Investigation

View full text Add to dashboard Cite

Adrenaline: communication by electron emission. Effect of concentration and temperature. Product analysis

Abstract: Background-Based on the recent findings about the ability of sexual hormones to emit electrons (e aq − ) and to act as electron mediator, it was of interest to investigate adrenaline as an

Cited by 5 publications

References 25 publications

Hormones: electron emission, communication, mutual interaction, regeneration, metabolites, carcinogenesis and receptor action

Hormones: electron emission, communication, mutual interaction, regeneration, metabolites, carcinogenesis and receptor action

Photo-induced regeneration of hormones by electron transfer processes: Potential biological and medical consequences

Method for regeneration of hormones: 17β-estradiol, 21α-hydroxyprogesterone and corticosterone. A pathway for a possible medical application

Contact Info

Product

Resources

About