Photo-induced regeneration of hormones by electron transfer processes: Potential biological and medical consequences

Abstract

Based on the previous results concerning electron transfer processes in biological substances, it was of interest to investigate if hormone transients resulting by e.g. electron emission can be regenerated.The presented results prove for the first time that the hormone transients originating by the electron emission process can be successfully regenerated by the transfer of electrons from a potent electron donor, such as vitamin C (VitC). Investigations were performed using progesterone (PRG), testosterone (TES) and estrone (E1) as representatives of hormones. By irradiation with monochromatic UV light (λ=254 nm) in a media of 40% water and 60% ethanol, the degradation as well as the regeneration of the hormones was studied with each hormone individually and in the mixture with VitC as a function of the absorbed UV dose, using HPLC. Calculated from the obtained initial yields, the determined regeneration of PRG amounted to 52.7%, for TES to 58.6% and for E1 to 90.9%. The consumption of VitC was determined in the same way.The reported results concerning the regeneration of hormones by the transfer of electrons from an electron donor offer a new, promising method for the therapy with hormones. As a consequence of the regeneration of hormones, a decreased formation of carcinogenic metabolites is expected.

Hormones: electron emission, communication, mutual interaction, regeneration, metabolites, carcinogenesis and receptor action

“…The hormone regeneration was achieved by electron transfer from a potent electron donor-like vitamin C (Vit C) during the life time (status nascendistate) of the hormone transients. The regeneration effect was reported of progesterone (PRG), testosterone (TES) and estrone (E1) [23] as well as of 17 β -estradiol (17 β E2), 21 α -hydroxyprogesterone (12 α -OHPRG) and corticosterone (CORT) [9] in polar media (40/60 = water/ethanol), pH = 7.4 and 37 ° C by substrate excitation with UV-light ( λ = 254 nm). In order to avoid hormone oxidation, the samples were dissolved and UV-irradiated in airfree media.…”

Emittieren und regenerieren

“…B. Vitamin C) regenerieren? Experimente bestätigen den erwarteten Effekt:18,19 Der Regenerationsprozess eines Hormons hängt von seiner Molekülstruktur ab und somit auch von seiner Fähigkeit, e—aq zu emittieren.Mit steigender Konzentration an Vitamin C steigt auch die Hormonregeneration. Jedoch ist dieser Effekt nicht proportional zum Verbrauch an Vitamin C. Dies deutet auf recht komplizierte Regenerationsprozesse hin, bei denen der pH‐Wert des Mediums und die Temperatur eine wesentliche Rolle spielen.…”