Adrenalectomy Improves Outcomes of Selected Patients with Metastatic Carcinoma

Vazquez, Bianca J.; Richards, Melanie L.; Lohse, Christine M.; Thompson, Geoffrey B.; Farley, David R.; Grant, Clive S.; Huebner, Marianne; Moreno, J.L. Pontones

doi:10.1007/s00268-012-1506-3

Cited by 78 publications

(62 citation statements)

References 29 publications

(44 reference statements)

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“…Our results reinforce those previously reported in the literature by showing that resection of adrenal metastases may be associated with prolonged survival (5-year CSS and RFS rates: 53.3% and 26.4%, respectively) [3,[7][8][9][10][13][14]. However, our 5-year CSS rate exceeds those reported in other series (from 30 to 40%) [3,[7][8][9][10][13][14]. This may be due to the larger proportion in our series of patients with renal cell carcinoma who have been shown to have a significantly better prognosis compared with other primary tumors [8,[15][16].…”

Section: A C C E P T E D Accepted Manuscriptsupporting

confidence: 81%

“…They found a survival benefit in favour of surgical resection for metastases arising from lung, kidney, pancreas and sarcoma but their findings are debatable due to their study design [14]. Our results reinforce those previously reported in the literature by showing that resection of adrenal metastases may be associated with prolonged survival (5-year CSS and RFS rates: 53.3% and 26.4%, respectively) [3,[7][8][9][10][13][14]. However, our 5-year CSS rate exceeds those reported in other series (from 30 to 40%) [3,[7][8][9][10][13][14].…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

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Patient selection for laparoscopic excision of adrenal metastases: A multicenter cohort study

Gryn

Peyronnet

Manunta

et al. 2015

International Journal of Surgery

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Patient selection for laparoscopic excision of adrenal metastases: a multicenter cohort study. International Journal of Surgery, Elsevier, 2015, 24 Part A, pp.75-80. 10.1016/j.ijsu.2015 M A N U S C R I P T A C C E P T E D ABSTRACT:Introduction: The use of laparoscopy for the excision of adrenal metastasis remains controversial.We aimed to report oncological and perioperative outcomes of laparoscopic excision of adrenal metastases and to seek for predictive factors of unfavourable oncological outcomes. Results: Forty-three patients who underwent a total of 45 LA were included for analysis. There were 8 complications (17.8%). Positive surgical margins were found in 12 specimens (26.7%). After a median follow-up of 37 months, estimated overall survival rates were 89.5% and 51.5% at 1 year and 5 years, respectively. In multivariable analysis the only predictor of unfavourable surgical outcomes was a tumor size > 5 cm (OR= 20.5; p=0.001). In multivariate analysis the pulmonary (OR=0.3; p=0.008) or "other" (OR= 0.1; p=0.0006) origin of the primary tumor was the only prognostic factor of shorter cancer specific survival. Methods Conclusion:Laparoscopic resection of adrenal metastasis can be safely performed in most patients but is associated with an increased risk of positive surgical margins and postoperative complications in larger tumors (> 5 cm). Adrenalectomy provides better oncological outcomes in metastases from renal cell carcinoma compared to other primary tumors.

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Section: A C C E P T E D Accepted Manuscriptsupporting

confidence: 81%

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Patient selection for laparoscopic excision of adrenal metastases: A multicenter cohort study

Gryn

Peyronnet

Manunta

et al. 2015

International Journal of Surgery

View full text Add to dashboard Cite

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“…В настоящее время до-стоверно установлено увеличение выживаемости после адренал-эктомии в случае метастазов рака почки, легких, поджелудочной железы и саркомы мягких тканей по сравнению с этим показате-лем неоперированных пациентов. В то же время влияние адренал-эктомии на выживаемость в случае метастазов иной природы остается малоизученным вследствие незначительного числа на-блюдений [7].…”

Section: хирургия 9 2016unclassified

“…В то же время положительное влияние на продолжительность жизни после хи-рургического лечения по поводу метастатического поражения надпочечников не получило статистического доказательства в силу незначительного числа наблюдений [7]. Еще большую ред-кость представляют описания удаления метастазов колоректаль-ного рака в надпочечник, возникших после оперативного лече-ния метастазов в легких.…”

Section: хирургия 9 2016unclassified

“…Рассматривая вопрос о хирургическом лечении, некоторые ав-торы отмечают, что выбор открытого или лапароскопического до-ступа не оказывает стратегического влияния на течение онкологи-ческого процесса и выживаемость пациентов, но имеет большое значение для качества жизни в послеоперационном периоде [7,15].…”

Section: хирургия 9 2016unclassified

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Adrenalectomy in treatment of metastatic colorectal cancer

Kharnas

Polunin

Паршин

et al. 2016

Khir. Z. im. N.I. Pirogova

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Adrenal Tumours

Arenas¹,

Habra²,

Perrier³

2017

TNM Online

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Summary Adrenal tumours have various patterns of presentation depending on their endocrine functionality and oncological potential. Evaluation of the patient with an adrenal tumour requires a thorough understanding of adrenal physiology and proper application of imaging and biochemical testing to guide therapy. The spectrum of adrenal disease is wide and includes endocrinopathies such as Cushing syndrome, Conn syndrome (hyperaldosteronism) and phaeochromocytoma. Although rare, primary adrenal malignancy dictates a different therapeutic approach from that for benign disease. Non‐functional disease includes benign ‘incidentalomas’, malignant masses, both of primary adrenal origin and of metastatic origin, from another primary site. We describe the presentation and natural history of common adrenal pathologies, including the diagnostic work‐up and treatment options. Furthermore, operative strategy is discussed with details regarding perioperative issues specific to each pathological entity being treated. A summary of ongoing research in adrenal tumours and controversies in the field is included.

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Adrenalectomy Improves Outcomes of Selected Patients with Metastatic Carcinoma

Abstract: An aggressive surgical approach results in improved OS in patients with metastatic disease arising from soft tissues, kidney, lung, and pancreas. Other tumors may benefit, but larger study cohorts are needed for a meaningful comparison.

Cited by 78 publications

References 29 publications

Patient selection for laparoscopic excision of adrenal metastases: A multicenter cohort study

Patient selection for laparoscopic excision of adrenal metastases: A multicenter cohort study

Adrenalectomy in treatment of metastatic colorectal cancer

Adrenal Tumours

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