Adrenal Schwannoma: A Rare Incidentaloma

Kumar, Sumit; Karthikeyan, Vilvapathy Senguttuvan; Manohar, C S; Sreelakshmi, K.; Maregowda, Shivalingaiah

doi:10.7860/jcdr/2016/20405.8265

Cited by 7 publications

(6 citation statements)

References 5 publications

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“…Large AS can be seen under a microscope showing inhomogeneous low-density lesions, while a few solid tumors showed uniform density and CT value similar to muscle signal intensity, which could be significantly enhanced. (4) Calcification is an important feature of retroperitoneal schwannoma. CT findings may be punctate, mottled, or curvilinear.…”

Section: Discussionmentioning

confidence: 99%

Clinical presentation, management, and research progress of adrenal schwannoma

Zhang

Wen

et al. 2022

Front. Surg.

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ObjectiveThis study shares our experience in managing adrenal schwannoma (AS).MethodsThe clinical data of eight patients with AS in our hospital from April 2007 to April 2022 were analyzed retrospectively.ResultsA total of 1309 patients with adrenal lesions were treated in the affiliated hospital of Guizhou Medical University for 15 years, of which only 8 cases were diagnosed as AS, accounting for 0.61%. Among the eight patients with AS, there were five females and three males, with an average age of 48.63 ± 12.05 years, and the average maximum diameter of the tumor was 6.96 ± 1.83 cm. All patients underwent adrenalectomy and were pathologically diagnosed as AS after the operation. The average follow-up time of eight patients with AS was 60.13 ± 22.33 months, and there was no recurrence or metastasis.ConclusionThe retroperitoneum is an uncommon site for schwannoma tumors, and among adrenal incidentalomas, the schwannoma is rare. The disease lacks specific clinical and imaging features, but correct diagnosis before the pathological examination is very important for clinical management and surgical decision. When imaging examination indicates a slow-growing retroperitoneal mass, schwannoma should be considered. Surgical resection is the main treatment. Pathology is the gold standard for diagnosis. Most of the tumors are benign and have a good prognosis. There is a risk of recurrence after the operation, and it should be monitored actively.

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Section: Discussionmentioning

confidence: 99%

Clinical presentation, management, and research progress of adrenal schwannoma

Zhang

Wen

et al. 2022

Front. Surg.

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“…AS is a rare incidentaloma found in the adrenal medulla, and fewer than 100 cases have been reported to date (10,6,(11)(12)(13)(14)(15)(16)(17)(18). The vast majority of AS patients are sporadic.…”

Section: Discussionmentioning

confidence: 99%

“…Due to its low incidence, only a few case reports and small case series have been published to date (10). Thus, comprehensive understanding of the clinical features, diagnosis, and clinical treatment of AS is necessary.…”

Section: Introductionmentioning

confidence: 99%

Clinical features and outcomes of adrenal schwannoma: a study of 13 cases from a single centre

Henghai¹,

Ding

Lin³

et al. 2021

Endocrine Connections

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Background: Adrenal schwannomas (AS) are extremely rare neoplasms. This study shares our experience regarding the diagnosis and operative management of AS. Methods: Clinical details, radiologic, laboratory, and pathologic findings as well as follow-up data were analyzed retrospectively for 13 AS patients who accepted surgery at a tertiary referral hospital in China between January 1, 1996, and December 31, 2017. Results: The mean age of the patients at diagnosis was 44.7 ± 13.7 years (range 19–62 years; male: female ratio, 1:1.16), of whom 7 patients had unilateral AS on the right side, and the remaining 6 on the left side. None of the cases were hormonally active. None of the 13 cases were diagnosed as AS by computed tomography imaging before the operation. Among the patients, 10 were asymptomatic. The mean preoperative size was 7.1 ± 3.2 cm (range 1.6–12.6 cm). All patients underwent surgery, with open adrenalectomy in 5 patients and laparoscopy in 8 patients. The mean tumor size on pathologic examination was 6.8 ± 3.0 cm (range 3.0–11.7 cm). The surgical specimens were confirmed by pathological examination. During a median follow-up of 60.8 ± 17.7 months, no patients showed recurrence or metastasis. Conclusion: The preoperative diagnosis of AS remains difficult despite the advances in imaging examinations. After complete resection, the prognosis of AS is excellent.

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“…On gross examination, adrenal schwannomas appear as a well-circumscribed, firm, round, and tan-yellow to grayishwhite mass. Although the majority of them are solid with homogenous consistency, some may have cystic areas and appear larger or may have areas of calcification or hemorrhage [14]. Histologically, schwannomas are diagnosed based on the detection of spindle cells with characteristic elongated to wavy nuclei, showing alternating cellular (Antoni A) and hypocellular (Antoni B) regions [15].…”

Section: Discussionmentioning

confidence: 99%

Schwannoma Misdiagnosed as Adrenal Adenoma: A Case Report and Review of the Literature

Almalki

Alotaibi

Ahmad

et al. 2020

Case Reports in Endocrinology

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Schwannoma is a benign neurogenic tumor originating from the neural sheath of Schwann cells. It is an extremely rare cause of adrenal adenoma which is very difficult to diagnose preoperatively. We report the case of a right adrenal schwannoma discovered incidentally in a 62-year-old woman during evaluation of right flank pain. The biochemical and hormonal evaluations were unremarkable. Radiological examination revealed a 4.8 cm lesion keeping with right adrenal adenoma. Surgical intervention was done due to the large size of the tumor, and laparoscopic right adrenalectomy was performed. The postoperative course was uneventful. Histological examination established the diagnosis of schwannoma, which was further confirmed by immunohistochemical staining. In conclusion, adrenal schwannoma is extremely rare and can be misdiagnosed as nonsecreting adrenal adenoma. Complete surgical excision is the treatment of choice which is associated with favorable outcome and also helps in clarifying its histopathological nature.

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Adrenal Schwannoma: A Rare Incidentaloma

Cited by 7 publications

References 5 publications

Clinical presentation, management, and research progress of adrenal schwannoma

Clinical presentation, management, and research progress of adrenal schwannoma

Clinical features and outcomes of adrenal schwannoma: a study of 13 cases from a single centre

Schwannoma Misdiagnosed as Adrenal Adenoma: A Case Report and Review of the Literature

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