Adrenal mitochondrial benzodiazepine receptors are sensitive to agents active at the dopamine receptor

Amiri, Zamir; Katz, Yeshayahu; Weizman, Abraham; Bidder, Miri; Snyder, Solomon H.; Gavish, Moshe

doi:10.1016/0006-2952(93)90242-o

Cited by 6 publications

(1 citation statement)

References 17 publications

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“…It is worth to notice the results obtained with immunoassay as well as those determined with radioimmunoassay in our previous study were comparable (28.6±5.2 and 23.5±6.1). In the experimental study Amiri et al [37] used even doubled dose of MCP than we were for 21 days and found 2,5 fold increase of PRL concentration comparing to control rats. The capability of MCP to induce hyperprolactinemia was reported by others too [38,40].…”

Section: Discussionmentioning

confidence: 99%

Morphological and immunohistochemical comparison of three rat prostate lobes (lateral, dorsal and ventral) in experimental hyperprolactinemia.

Słuczanowska-Głąbowska

Wylot²,

Głąbowski³

et al. 2010

Folia Histochem Cytobiol.

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Abstract:The prolactin plays an important role in the regulation of growth and differentiation of prostate gland besides androgens. The goal of this study was to reveal the influence of elevated prolactin concentration on epithelial cells of prostate. We compared the morphology of epithelial cells of prostate dorsal, lateral and ventral lobes and expression of androgen receptors in these cells in rats with hyperprolactinemia and in control rats. We used sexually mature male Wistar rats. The experimental rats received metoclopramide; the control group received saline in the same way. The prostate dorsal, lateral and ventral lobes were collected routinely for light and electron microscopy. The intensity of immunohistochemical reaction of androgen receptor in epithelial cells of dorsal, lateral and ventral lobes was evaluated by measure of optical density with computer image analysis. The light and electron (transmission and scanning) microscopes were used for morphological observations. Results: In experimental rats twofold increase in prolactin and twofold decrease in testosterone found. In experimental group the expression of androgen receptor was lower in columnar epithelial cells of dorsal and ventral lobes but higher in lateral one. We observed morphological abnormalities in columnar epithelial cells of lateral and dorsal lobes. The columnar epithelial cells of ventral lobes didn't show any morphological changes in hyperprolactinemia.

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Section: Discussionmentioning

confidence: 99%

Morphological and immunohistochemical comparison of three rat prostate lobes (lateral, dorsal and ventral) in experimental hyperprolactinemia.

Słuczanowska-Głąbowska

Wylot²,

Głąbowski³

et al. 2010

Folia Histochem Cytobiol.

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Peripheral-type benzodiazepine receptors: Their implication in brain disease

Veenman

Gavish

2000

Drug Dev. Res.

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Modifications of apoptosis-related protein levels in lymphocytes of patients with Parkinson?s disease. The effect of dopaminergic treatment

Blandini¹,

Cosentino

Mangiagalli³

et al. 2004

J Neural Transm

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In this study, we investigated whether changes in the regulatory mechanisms of apoptosis and oxidative stress may be detected, peripherally, in patients with Parkinson's disease (PD). For this purpose, we measured caspase-3 activity, Bcl-2 concentrations, peripheral benzodiazepine receptor (PBR) expression and Cu/Zn superoxide dismutase (SOD) concentrations in lymphocytes of untreated PD patients, patients treated only with L-Dopa or with L-Dopa and dopamine agonists and healthy volunteers. Caspase-3 activity was significantly increased in all PD patient groups. Patients treated with L-Dopa and dopamine agonists showed the lowest values of Bcl-2, coupled with the highest density of PBRs, while increased levels of Cu/Zn SOD were found in the group under monotherapy with L-Dopa. We also found, in PD patients, clear, negative correlations between Bcl-2 levels and both duration and severity of the disease. Our findings point to the existence of changes in the regulatory mechanisms of apoptosis in PD patients -- observable outside the central nervous system -- which seem to be modulated by the pharmacological treatment with dopaminergic agents.

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Adrenal mitochondrial benzodiazepine receptors are sensitive to agents active at the dopamine receptor

Cited by 6 publications

References 17 publications

Morphological and immunohistochemical comparison of three rat prostate lobes (lateral, dorsal and ventral) in experimental hyperprolactinemia.

Morphological and immunohistochemical comparison of three rat prostate lobes (lateral, dorsal and ventral) in experimental hyperprolactinemia.

Peripheral-type benzodiazepine receptors: Their implication in brain disease

Modifications of apoptosis-related protein levels in lymphocytes of patients with Parkinson?s disease. The effect of dopaminergic treatment

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