Adrenal corticosteroids, their receptors and hypertension

Hu, Xiao; Bolten, Charles W.

doi:10.1002/ddr.20158

Cited by 5 publications

(3 citation statements)

References 122 publications

(116 reference statements)

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“…Previous studies have shown that glucocorticoids can affect insulin resistance, gluconeogenesis, liposynthesis, accumulation of visceral fat, vascular reactivity, vascular remodeling, renal sodium reabsorption, and blood pressure [5–9, 40, 41]. However, the mechanisms whereby glucocorticoids can cause hypertension in humans remain unclear.…”

Section: Discussionmentioning

confidence: 99%

“…However, the mechanisms whereby glucocorticoids can cause hypertension in humans remain unclear. Most evidence suggested that glucocorticoids increase blood pressure through the modulation of vascular structure and function, renal sodium reabsorption, and metabolic changes [5–9, 40, 41]. In this study, we examined whether pharmacological inhibition of 11 β -HSD1 decreases blood pressure through a natriuretic mechanism.…”

Section: Discussionmentioning

confidence: 99%

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Chronic Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity Decreases Hypertension, Insulin Resistance, and Hypertriglyceridemia in Metabolic Syndrome

Schnackenberg

Costell

Krosky

et al. 2013

BioMed Research International

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Metabolic syndrome is a constellation of risk factors including hypertension, dyslipidemia, insulin resistance, and obesity that promote the development of cardiovascular disease. Metabolic syndrome has been associated with changes in the secretion or metabolism of glucocorticoids, which have important functions in adipose, liver, kidney, and vasculature. Tissue concentrations of the active glucocorticoid cortisol are controlled by the conversion of cortisone to cortisol by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). Because of the various cardiovascular and metabolic activities of glucocorticoids, we tested the hypothesis that 11β-HSD1 is a common mechanism in the hypertension, dyslipidemia, and insulin resistance in metabolic syndrome. In obese and lean SHR/NDmcr-cp (SHR-cp), cardiovascular, metabolic, and renal functions were measured before and during four weeks of administration of vehicle or compound 11 (10 mg/kg/d), a selective inhibitor of 11β-HSD1. Compound 11 significantly decreased 11β-HSD1 activity in adipose tissue and liver of SHR-cp. In obese SHR-cp, compound 11 significantly decreased mean arterial pressure, glucose intolerance, insulin resistance, hypertriglyceridemia, and plasma renin activity with no effect on heart rate, body weight gain, or microalbuminuria. These results suggest that 11β-HSD1 activity in liver and adipose tissue is a common mediator of hypertension, hypertriglyceridemia, glucose intolerance, and insulin resistance in metabolic syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chronic Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity Decreases Hypertension, Insulin Resistance, and Hypertriglyceridemia in Metabolic Syndrome

Schnackenberg

Costell

Krosky

et al. 2013

BioMed Research International

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“…In mammals, the adrenal glands are endocrine glands that are responsible for releasing hormones including corticosteroids (such as cortisol) and catecholamines (such as epinephrine and norepinephrine) (Hu and Bolten 2006;Fung et al 2008). Amino acids play many roles in the adrenal glands.…”

Section: Determination Of Amino Acids In Mouse Plasma and Adrenal Glamentioning

confidence: 99%

Rapid determination of amino acids in biological samples using a monolithic silica column

2011

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A high-performance liquid chromatography method in which fluorescence detection is used for the simultaneous determination of 21 amino acids is proposed. Amino acids were derivatized with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F) and then separated on a monolithic silica column (MonoClad C18-HS, 150 mm×3 mm i.d.). A mixture of 25 mM citrate buffer containing 25 mM sodium perchlorate (pH 5.5) and acetonitrile was used as the mobile phase. We found that the most significant factor in the separation was temperature, and a linear temperature gradient from 30 to 49°C was used to control the column temperature. The limits of detection and quantification for all amino acids ranged from 3.2 to 57.2 fmol and 10.8 to 191 fmol, respectively. The calibration curves for the NBD-amino acid had good linearity within the range of 40 fmol to 40 pmol when 6-aminocaproic acid was used as an internal standard. Using only conventional instruments, the 21 amino acids could be analyzed within 10 min. This method was found to be suitable for the quantification of the contents of amino acids in mouse plasma and adrenal gland samples.

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The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-β-hydroxylase

Adams¹,

Hu²,

Jeng³

et al. 2010

Bioorganic & Medicinal Chemistry Letters

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Adrenal corticosteroids, their receptors and hypertension

Cited by 5 publications

References 122 publications

Chronic Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity Decreases Hypertension, Insulin Resistance, and Hypertriglyceridemia in Metabolic Syndrome

Chronic Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity Decreases Hypertension, Insulin Resistance, and Hypertriglyceridemia in Metabolic Syndrome

Rapid determination of amino acids in biological samples using a monolithic silica column

The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-β-hydroxylase

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