Adrenal Cortical Rests in the Fallopian Tube: Report of a Case and Review of the Literature

Tzigkalidis, Theodoros; Skandalou, Eleni; Μanthou, Maria Eleni; Kolovogiannis, Nikolaos; Meditskou, Soultana

doi:10.3390/medicines8030014

Cited by 5 publications

(4 citation statements)

References 20 publications

(46 reference statements)

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“…They found this nodule to be positive by immunohistochemistry for MART1, synaptophysin, calretinin, and inhibin-A. As in our case, the EAT showed immunoreactivity for the calretinin and inhibin-A [ 8 ].…”

Section: Discussionsupporting

confidence: 69%

“…The adrenal cortex is typically immunoreactive for Melan-A (MART1), inhibin, synaptophysin, and calretinin and has a high nuclear positivity (86%) to antisteroidogenic factor-1 (anti-SF-1). While metastatic clear renal cell carcinoma is negative for these markers and positive for CD10, AE1/AE3, and carbonic anhydrase, the ovarian hilus cell heterotopia of the fallopian tube shows similar immunopositivity to adrenal cortical cells with the difference of the additional positivity for chromogranin, which is negative in adrenal cortical cells [ 8 ]. In our case, we noted immunoreactivity to inhibin and calretinin that was compatible with the published data.…”

Section: Discussionmentioning

confidence: 99%

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Adrenal Cortical Rests in the Fallopian Tube: A Case Report and Review of the Literature

Hafiz¹,

Alturkistani²

2022

Cureus

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Ectopic adrenal rest is a rare phenomenon usually discovered incidentally during microscopic evaluation. The most common site reported in the literature is the genitourinary system and pelvis. Ectopic adrenal rest is more common in male than in female children. The documented site for females is mainly along the broad ligament. However, only two cases of ectopic adrenal rest in the fallopian tube have been reported in the literature, showing that they are extremely rare.In this article, we outline a case of adrenal cortical rest that was discovered incidentally during a microscopic examination of the left fallopian tube after a total hysterectomy with a left salpingooophorectomy specimen from a 49-year-old female patient who was complaining of severe bleeding related to severe adenomyosis.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Adrenal Cortical Rests in the Fallopian Tube: A Case Report and Review of the Literature

Hafiz¹,

Alturkistani²

2022

Cureus

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“…Most of the ectopic adrenal tissue becomes atrophic in adolescence, but some rests can be persistent and rarely can even develop similar pathological changes as the normal adrenal glands, such as hyperplasia or neoplasia. 15 Our patients all had adrenal rests in inguinal hernia sacs. The second most common benign lesion seen in our study is endometriosis, which is more commonly present in umbilical than inguinal hernia sacs.…”

Section: Discussionmentioning

confidence: 61%

Histopathological Findings in Hernia Sacs: A Clinical and Pathological Review

et al. 2023

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Routine histopathological examination of hernia sac in adults remains a controversial topic. We undertook a retrospective study to assess possible clinical benefits of pathological examination of hernia sac specimens. Our pathology database between 1992 and 2020 was searched for adult specimens submitted as hernia sac. The clinical and pathological data of patients with abnormal histopathological findings were reviewed. There were 5424 hernia sac specimens (3722 inguinal, 1625 umbilical, and 77 femoral), 32/5424 (0.59%) with malignancies (28 epithelial and 4 lymphoid) and 25/32 were located in the umbilical region. Twelve out of twenty-five malignancies (48%) presented as primary clinical manifestations of the diseases (5 GI tract carcinomas, 5 gynecological tract carcinomas, and 2 lymphoid neoplasms); and 13/25 (52%) specimens were involved by previously known tumors (8 gynecological carcinomas, 3 colon carcinomas, 1 breast carcinoma, and 1 lymphoma). Among the 7 inguinal hernia sacs with malignancies, 3 (42.9%) were primary presentations of the tumors (2 prostatic carcinomas, 1 pancreatic carcinoma), and 4 (57.1%) were previously known tumors (2 ovarian carcinomas, 1 colon carcinoma, 1 lymphoid). Benign lesions were 12/5424 (0.22%), including 7 adrenal rests, 4 endometriosis, and 1 inguinal sarcoidosis. The incidence of hernia sacs with malignancies was 32/5424 (0.59%), most commonly from nearby organs in gynecological tract. However distant metastases from breast were also present. Near half of the hernia sac with malignancies (15/32, 47%) presented as the first clinical manifestation. Routine histopathological examination of hernia sac in adults is recommended, since it may provide important clinical information.

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“…The lack of clarity concerning the cellular origin appeared to be true for the paraganglioma of the fallopian tube described in the current report; i.e., paraganglioma of the fallopian tube can develop from extra-adrenal paraganglia that exist near the fallopian tube. Another possibility is that adrenomedullary cells in the adrenal rest of the fallopian tube[ 13 ], which have been rarely discovered and clarified without clinical significance, could be the origin.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Paraganglioma of the Fallopian Tube Presenting as Isolated Fallopian Tube Torsion

et al. 2022

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A 32-year-old woman with no previous disease history was presented with worsening right-lower abdominal pain, which lasted for 4 days. On magnetic resonance imaging, a solid mass measuring 48 mm in longitudinal diameter connected with a tortuous structure that appeared to be a fallopian tube was identified in the right-lower abdomen. Because the right ovary was identified at a slightly distant location, isolated fallopian tube torsion with heterogeneous mass was suspected. The isolated fallopian tube torsion without ovarian involvement was laparoscopically confirmed. After detorsion, solid necrotized mass in the distal portion of the right fallopian tube near the fimbrial end became evident, followed by uneventful right salpingectomy with ovarian preservation. The pathological diagnosis was paraganglioma of the fallopian tube with positive cells for neural cell adhesion molecule, neuron-specific enolase, and S-100 protein in the viable peripheral foci of the massively necrotized hemorrhagic mass. Recurrence was not observed after 1.5 years.

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Adrenal Cortical Rests in the Fallopian Tube: Report of a Case and Review of the Literature

Cited by 5 publications

References 20 publications

Adrenal Cortical Rests in the Fallopian Tube: A Case Report and Review of the Literature

Adrenal Cortical Rests in the Fallopian Tube: A Case Report and Review of the Literature

Histopathological Findings in Hernia Sacs: A Clinical and Pathological Review

Paraganglioma of the Fallopian Tube Presenting as Isolated Fallopian Tube Torsion

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