Adoptive Transfusion of Tolerance Dendritic Cells Prolong the Survival of Cardiac Allograft: A Systematic Review on 44 Animal Studies

Wu, Qun; Shan, Juan; Sun, Xuefeng; Zhou, Nanruoyi; Yang, Ting; Guo, Junjun; Xia, Jinxing; Li, Feng; Li, P. Y.

doi:10.1097/00007890-201211271-01858

Cited by 3 publications

(5 citation statements)

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“…This systematic review only assessed the influence of adoptive transfusion of Tol-DCs on islet allograft survival. However, we have also conducted six systematic reviews on its effect in other organ transplantation models, which has been published [31] or are in preparation.…”

Section: Discussionmentioning

confidence: 99%

“…During organ transplantation, tolerogenic DCs (Tol-DCs) favor graft acceptance. They are characterized by increased expression of CCR7, CCR5, CCR6, and other chemokine receptors, decreased expression of major histocompatibility complex II (MHC-II), and costimulatory molecules such as CD80 and CD86 [31]. Tol-DCs induce T cells hypo-reactivity, drive the generation of T regulatory cells (Treg), and induce antigen-specific immune tolerance.…”

Section: Introductionmentioning

confidence: 99%

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Adoptive Infusion of Tolerogenic Dendritic Cells Prolongs the Survival of Pancreatic Islet Allografts: A Systematic Review of 13 Mouse and Rat Studies

Sun

Shan

et al. 2012

PLoS ONE

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ObjectiveThe first Phase I study of autologous tolerogenic dendritic cells (Tol-DCs) in Type 1 diabetes (T1D) patients was recently completed. Pancreatic islet transplantation is an effective therapy for T1D, and infusion of Tol-DCs can control diabetes development while promoting graft survival. In this study, we aim to systematically review islet allograft survival following infusion of Tol-DCs induced by different methods, to better understand the mechanisms that mediate this process.MethodsWe searched PubMed and Embase (from inception to February 29th, 2012) for relevant publications. Data were extracted and quality was assessed by two independent reviewers. We semiquantitatively analyzed the effects of Tol-DCs on islet allograft survival using mixed leukocyte reaction, Th1/Th2 differentiation, Treg induction, and cytotoxic T lymphocyte activity as mechanisms related-outcomes. We discussed the results with respect to possible mechanisms that promote survival.ResultsThirteen articles were included. The effects of Tol-DCs induced by five methods on allograft survival were different. Survival by each method was prolonged as follows: allopeptide-pulsed Tol-DCs (42.14±44 days), drug intervention (39 days), mesenchymal stem cell induction (23 days), genetic modification (8.99±4.75 days), and other derivation (2.61±6.98 days). The results indicate that Tol-DC dose and injection influenced graft survival. Single-dose injections of 104 Tol-DCs were the most effective for allograft survival, and multiple injections were not superior. Tol-DCs were also synergistic with immunosuppressive drugs or costimulation inhibitors. Possible mechanisms include donor specific T cell hyporesponsiveness, Th2 differentiation, Treg induction, cytotoxicity against allograft reduction, and chimerism induction.ConclusionsTol-DCs induced by five methods prolong MHC mismatched islet allograft survival to different degrees, but allopeptide-pulsed host DCs perform the best. Immunosuppressive or costimulatory blockade are synergistic with Tol-DC on graft survival. Multiple injections are not superior to single injection. Yet more rigorously designed studies with larger sample sizes are still needed in future.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adoptive Infusion of Tolerogenic Dendritic Cells Prolongs the Survival of Pancreatic Islet Allografts: A Systematic Review of 13 Mouse and Rat Studies

Sun

Shan

et al. 2012

PLoS ONE

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“…23 ImDCs are characterized by increased expression of FccRII, TLRs, DEC-205, CCR1, CCR2, CCR7, CCR5, CCR6, CXCR1, CXCR2 and PD-L1, decreased expression of MHC-II, and costimulatory molecules, such as CD86, CD40, CD54 and PD-L2. [24][25][26][27][28] These imDCs have been described to have the capacity to induce or expand Tregs. However, some studies have shown that phenotypically mature DCs (high expression of costimulatory molecules) do not always induce Th1 responses but instead promote Tregs.…”

Section: The Induction Of Tol-dcsmentioning

confidence: 99%

Tolerogenic dendritic cells and their applications in transplantation

Shi

2014

Cell Mol Immunol

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In transplantation immunology, the ultimate goal is always to successfully and specifically induce immune tolerance of allografts. Tolerogenic dendritic cells (tol-DCs) with immunoregulatory functions have attracted much attention as they play important roles in inducing and maintaining immune tolerance. Here, we focused on tol-DCs that have the potential to promote immune tolerance after solid-organ transplantation. We focus on their development and interactions with other regulatory cells, and we also explore various tol-DC engineering protocols. Harnessing tol-DCs represents a promising cellular therapy for promoting long-term graft functional survival in transplant recipients that will most likely be achieved in the future.

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“…√ −: incomplete data. Criteria: 1 Peer reviewed publication; 2 Random allocation of treatment and control; 3 Animal species (inbred line, age-matched, MHC mismatch); 4 Sample size calculation (sample size of both control and experimental groups must be clarified); 5 Compliance with animal welfare regulation; 6 Statement of potential conflict of interest (source of funds must be clarified).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…This systematic review only assessed the influence of adoptive transfusion of Tol-DCs on small intestine allograft survival. However, we have also conducted six systematic reviews on its effect in other organ transplantation models, which have been published (2,3) or are in preparation.…”

Section: Limitations Of Our Reviewmentioning

confidence: 99%

Adoptive infusion of tolerance dendritic cells prolongs survival of small intestine allografts in rats: systematic review and meta‐analysis

Sun

Shan

et al. 2013

J Evidence Based Medicine

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Our results demonstrated that Tol-DCs induced by four methods prolong rat small intestine allograft survival. Intravenous infusion of 5×10(6) to 6×10(6) Tol-DCs was the optimum dose in rat small intestine transplantation. Immunosuppressive or costimulatory blockade was synergistic with Tol-DC on graft survival. Additional high-quality studies with larger sample sizes are needed to better investigate small intestinal graft longer term survival.

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Adoptive Transfusion of Tolerance Dendritic Cells Prolong the Survival of Cardiac Allograft: A Systematic Review on 44 Animal Studies

Cited by 3 publications

References 0 publications

Adoptive Infusion of Tolerogenic Dendritic Cells Prolongs the Survival of Pancreatic Islet Allografts: A Systematic Review of 13 Mouse and Rat Studies

Adoptive Infusion of Tolerogenic Dendritic Cells Prolongs the Survival of Pancreatic Islet Allografts: A Systematic Review of 13 Mouse and Rat Studies

Tolerogenic dendritic cells and their applications in transplantation

Adoptive infusion of tolerance dendritic cells prolongs survival of small intestine allografts in rats: systematic review and meta‐analysis

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