Adolescent Personality Risk Factors for Tobacco Smoking and Alcohol Misuse in Adult Men

Czaderny, Krzysztof

doi:10.1080/10826084.2020.1741635

Cited by 2 publications

(2 citation statements)

References 54 publications

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“…Apart from abovementioned anatomical and physiological disparities, factors associated with health behaviors and beliefs might also contribute to gender discrepancies in PPVs of preliminary screening for colorectal neoplasia. Males who conformed to masculinity norms (i.e., self-reliance, avoidance of femininity, heterosexual self-presentation, and risk-taking) might be motivated by more severe symptoms to participate in cancer screening and present superior PPVs [28][29][30]. In addition, females reported significant discomfort during colonoscopy [31], and had lower completion rate of colonoscopy [32], as compared with males.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with positive predictive value of preliminary screening in a two-step screening strategy for colorectal neoplasms in China

Qiu

Deng

et al. 2022

Discov Onc

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Background The positive predictive value (PPV) of high risk factor questionnaire (HRFQ) plus fecal immunochemical test (FIT) as preliminary screening strategy for colorectal-related neoplasia is relatively low. We aim to explore independent factors associated with PPVs of HRFQ combined FIT for selecting high risk individuals for colonoscopy. Methods A total of 6971 residents were enrolled in a community-based screening program. Participants who had positive results of HRFQ and/or FIT and subsequently received colonoscopy were involved. The associations of socio-demographic factors, lifestyle behaviors, and high risk factors of colorectal cancer with PPVs of HRFQ, FIT, and their combination were evaluated by multivariable logistic regression models. Results Among 572 involved cases, 249 (43.5%) colorectal neoplasms were detected by colonoscopy, including 71 advanced adenoma (12.4%) and 9 colorectal cancer (CRC) (1.6%). The PPVs of preliminary screening were 43.5% for total colorectal neoplasms, 14.0% for advanced neoplasm, and 1.6% for CRC. Adding positive HRFQ to FIT could improve the PPV from 3.5 to 8.0% for detecting CRC. Preliminarily screened positive individuals who were males [adjusted odds ratio (AOR): 1.95, 95% CI 1.31, 2.90; p < 0.001], elders (> 60 years) (AOR: 1.70, 95% CI 1.17, 2.46; p = 0.005), or ex-/current smokers (AOR: 3.04, 95% CI 1.31, 7.09; p = 0.10) had higher odds of PPVs of detecting colorectal neoplasms. Conclusions Combining HRFQ and FIT could largely improve PPVs for screening advanced neoplasm and CRC. Gender and age-specific FIT cut-off values as well as initiating ages for CRC screening might be recommended to improve the accuracy and effectiveness of current screening algorithm.

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Section: Discussionmentioning

confidence: 99%

Factors associated with positive predictive value of preliminary screening in a two-step screening strategy for colorectal neoplasms in China

Qiu

Deng

et al. 2022

Discov Onc

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“…Alcohol dependence affects from 2% to 4% of the world population, of which 80% to 90% smoke cigarettes [1][2][3][4][5]. Salivary diagnostics in addictions is increasing, as saliva contains many compounds that sensitively respond to toxic substances, which reflects real-time levels of these compounds/markers.…”

Section: Introductionmentioning

confidence: 99%

Salivary Carbohydrate-Deficient Transferrin in Alcohol- and Nicotine-Dependent Males

Waszkiewicz

Pawłowicz

Okuniewska

et al. 2020

JCM

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Serum carbohydrate-deficient transferrin (CDT), an 80 kDa glycoprotein, is one of the most commonly employed biomarkers to detect alcohol dependence. Some salivary glycoproteins such as α-amylase, clusterin, haptoglobin, light/heavy-chain immunoglobulin, and transferrin, which alter glycosylation in alcohol-dependent persons, have been suggested to be potential alcohol markers. However, their identification is based on indirect analysis of lectin glycosidic bonds and molecular weight. We investigated the CDT content in the saliva of alcohol- and nicotine-dependent men. The CDT concentration (ng/mL, ng/mg protein) was determined by an Enzyme-Linked Immunosorbent Assay (ELISA) commercial kit in 55 men: 20 healthy social drinkers (C), 10 chronic cigarette smokers (S), 10 alcohol-dependent non-smokers (A), and 15 alcohol-dependent smokers (AS). Surprisingly, there were no differences in the concentrations of CDT between the studied groups. Salivary pH was the lowest in the AS and the highest in the A group. Therefore, salivary CDT cannot be used as an alcohol dependence marker as measured by ELISA. We suggest that direct identification of glycoproteins is necessary to search for potential salivary alcohol biomarkers. Molecules smaller than 40 kDa, which easily translocate from blood to the saliva, might be preferred as salivary alcohol markers.

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Adolescent Personality Risk Factors for Tobacco Smoking and Alcohol Misuse in Adult Men

Cited by 2 publications

References 54 publications

Factors associated with positive predictive value of preliminary screening in a two-step screening strategy for colorectal neoplasms in China

Factors associated with positive predictive value of preliminary screening in a two-step screening strategy for colorectal neoplasms in China

Salivary Carbohydrate-Deficient Transferrin in Alcohol- and Nicotine-Dependent Males

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