Adolescent insanity revisited: Course and outcome in early-onset schizophrenia spectrum psychoses in an 8-year follow-up study

Remberk, Barbara; Bażyńska, Anna Katarzyna; Krempa-Kowalewska, Anna; Rybakowski, Filip

doi:10.1016/j.comppsych.2014.03.013

Cited by 23 publications

(12 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the predictive validity of the SIPS, particularly in children under age 10 years, is not established. Finally, the PS group was not limited to DSM-IV SZ due to (a) difficulty in determining if patients with early psychosis would settle into a categorical diagnosis of SZ or an affective psychosis (Consoli et al, 2014; Remberk et al, 2014) and (b) increasing biological evidence for heterogeneity among patients with SZ and for pleiotropy in the phenotypic expressions of SZ risk alleles (Kavanagh et al, 2015). Consequently, we employed a Research Domain Criteria (RDoC) approach, as recently advocated by the National Institute of Mental Health (Insel, 2014).…”

Section: Discussionmentioning

confidence: 99%

Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample

Gonzalez–Heydrich

Enlow

D’Angelo

et al. 2015

Schizophrenia Research

View full text Add to dashboard Cite

Background The N100 is a negative deflection in the surface EEG approximately 100ms after an auditory signal. It has been shown to be reduced in individuals with schizophrenia and those at clinical high risk (CHR). N100 blunting may index neural network dysfunction underlying psychotic symptoms. This phenomenon has received little attention in pediatric populations. Method This cross-sectional study compared the N100 response measured via the average EEG response at the left medial frontal position FC1 to 150 sinusoidal tones in participants ages 5 to 17 years with a CHR syndrome (n = 29), a psychotic disorder (n = 22), or healthy controls (n=17). Results Linear regression analyses that considered potential covariates (age, gender, handedness, family mental health history, medication usage) revealed decreasing N100 amplitude with increasing severity of psychotic symptomatology from healthy to CHR to psychotic level. Conclusions Longitudinal assessment of the N100 in CHR children who do and do not develop psychosis will inform whether it predicts transition to psychosis and if its response to treatment predicts symptom change.

show abstract

Section: Discussionmentioning

confidence: 99%

Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample

Gonzalez–Heydrich

Enlow

D’Angelo

et al. 2015

Schizophrenia Research

View full text Add to dashboard Cite

show abstract

“…The overall stability of ATPDs was estimated at around 65% on average after 4.5 years [78]. Women are significantly less likely than men to develop another diagnosis [10,19,46,66,[78][79][80]. The risk of relapse based on findings from a large meta-analysis was 13% after 6 months, 30% after 1 year, 38% after 2 years, and 54% after 3 or more years [81].…”

Section: Diagnostic Stability Course and Outcome Of Atpdsmentioning

confidence: 99%

Diagnostic validity of ICD-10 acute and transient psychotic disorders and DSM-5 brief psychotic disorder

Castagnini

Fusar‐Poli

2017

Eur. psychiatr.

View full text Add to dashboard Cite

show abstract

“…The current study is part of a larger early-onset psychosis follow-up project [15]. The study has been performed in accordance with the 1964 Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

Which Aspects of Long-Term Outcome Are Predicted by Positive and Negative Symptoms in Early-Onset Psychosis? An Exploratory Eight-Year Follow-Up Study

et al. 2014

Self Cite

View full text Add to dashboard Cite

Background: Early-onset psychoses show substantial variability of diagnostic and functional outcome. Finding reliable prognostic factors may allow to allocate resources to those with the worst prognosis. The aim of the study was to gain new insights regarding the potential value of baseline negative and positive symptoms as predictors of outcome in psychoses of early onset. Method: Sixty-three patients with early-onset schizophrenia spectrum psychosis hospitalized in an adolescent psychiatry unit were assessed with the Positive and Negative Syndrome Scale during the index admission. Associations with diagnosis, illness course and functional outcome were analysed in mean 8 years of follow-up (range 3.4-13.5 years). Results: The mean age at the index admission and the follow-up was 16.6 ± 1.2 and 24.5 ± 3.0 years, respectively. A significant majority of subjects continued psychiatric treatment (95%) and had been readmitted (71%). The mortality rate was 3% (suicide and accident). Negative symptoms were related to mental health service utilization during the follow-up. General severity of symptoms, specifically positive and cognitive factors were associated with the diagnosis of schizophrenia and inversely with diagnostic shift outside the schizophrenia spectrum at the catamnesis. Poor impulse control at baseline was associated with worse functional outcome. The drug-free subgroup with no occupational/educational activity compared with the drug-treated subjects showed lower levels of baseline negative symptomatology. Conclusion: The study findings suggest that in patients with early-onset psychosis negative and positive symptoms show a differential prognostic value. Pharmacotherapy may attenuate the effect of symptoms on functional outcome. These hypotheses need to be tested in future studies using confirmatory approaches.

show abstract

Adolescent insanity revisited: Course and outcome in early-onset schizophrenia spectrum psychoses in an 8-year follow-up study

Cited by 23 publications

References 28 publications

Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample

Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample

Diagnostic validity of ICD-10 acute and transient psychotic disorders and DSM-5 brief psychotic disorder

Which Aspects of Long-Term Outcome Are Predicted by Positive and Negative Symptoms in Early-Onset Psychosis? An Exploratory Eight-Year Follow-Up Study

Contact Info

Product

Resources

About