Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample

Gonzalez–Heydrich, Joseph; Enlow, Michelle Bosquet; D’Angelo, Eugene J.; Seidman, Larry J.; Gumlak, Sarah; Kim, April; Woodberry, Kristen A.; Rober, Ashley; Tembulkar, Sahil; Graber, Kelsey; O’Donnell, Kyle L.; Hamoda, Hesham M.; Kimball, Kara; Rotenberg, Alexander; Oberman, Lindsay M.; Pascual‐Leone, Álvaro; Keshavan, Matcheri S.; Duffy, Frank H.

doi:10.1016/j.schres.2015.10.037

Cited by 22 publications

(9 citation statements)

References 42 publications

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“…Participants with AN displayed a significantly greater N100 latency at baseline, which may be related to a deficit in selective attention [44,45] or to an increased state of arousal [46]. The latter interpretation would be consistent with the correlation of higher N100 latency to a dysfunction in the catecholamine production as evidenced by literature [47].…”

Section: The Baseline Differences In N100 Latency and The Musical Effsupporting

confidence: 59%

The song of Anorexia Nervosa: a specific evoked potential response to musical stimuli in affected participants

et al. 2020

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Research applying the EEG to AN is still limited, even though in other psychiatric disorders it permitted to find out the allmarks of the disorder. The aim of the study was to explore whether EEG recorded basal activity and reactivity to musical stimulation differs in anorexia nervosa (AN) as compared to healthy subjects (HS). Methods: Twenty female subjects (respectively 10 with AN and 10 HS) were administered a battery of psychometric tests and underwent EEG under three different conditions: 1) at baseline; 2) after a generic music stimulation; and 3) after a favorite music stimulation. EEGs of AN patients showed higher absolute amplitude of cortical slow waves (theta) in the parieto-occipital and temporal derivations, as far as for a deficit in the beta band. Results: They showed a higher N100 latency and a reduced P300 latency compared to HS. While N100 and P300 latency was sensitive to the musical stimulus in HS group, the AN group showed no difference after music stimulation. Conclusion: These data suggest that AN is accompanied by a state of brain hyperarousal with abnormal reactivity to environmental which is similar to the state of control subjects after musical stimulation. If confirmed, this finding may have treatment implications.

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Section: The Baseline Differences In N100 Latency and The Musical Effsupporting

confidence: 59%

The song of Anorexia Nervosa: a specific evoked potential response to musical stimuli in affected participants

et al. 2020

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“…Only a few electrophysiological studies were found, indicating changes in prepulse inhibition (Ziermans et al, 2012) and smaller N100 amplitudes in CHR‐P individuals compared with HC (Gonzalez‐Heydrich et al, 2015, 2016) (Table ).…”

Section: Resultsmentioning

confidence: 99%

Annual Research Review: Prevention of psychosis in adolescents – systematic review and meta‐analysis of advances in detection, prognosis and intervention

Catalán

Pablo

Serrano

et al. 2020

Child Psychology Psychiatry

118

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Background: The clinical high-risk state for psychosis (CHR-P) paradigm has facilitated the implementation of psychosis prevention into clinical practice; however, advancements in adolescent CHR-P populations are less established. Methods: We performed a PRISMA/MOOSE-compliant systematic review of the Web of Science database, from inception until 7 October 2019, to identify original studies conducted in CHR-P children and adolescents (mean age <18 years). Findings were systematically appraised around core themes: detection, prognosis and intervention. We performed meta-analyses (employing Q statistics and I 2 test) regarding the proportion of CHR-P subgroups, the prevalence of baseline comorbid mental disorders, the risk of psychosis onset and the type of interventions received at baseline. Quality assessment and publication bias were also analysed. Results: Eighty-seven articles were included (n = 4,667 CHR-P individuals). Quality of studies ranged from 3.5 to 8 (median 5.5) on a modified Newcastle-Ottawa scale. Detection: Individuals were aged 15.6 AE 1.2 years (51.5% males), mostly (83%) presenting with attenuated positive psychotic symptoms. CHR-P psychometric accuracy improved when caregivers served as additional informants. Comorbid mood (46.4%) and anxiety (31.4%) disorders were highly prevalent. Functioning and cognition were impaired. Neurobiological studies were inconclusive. Prognosis: Risk for psychosis was 10.4% (95%CI: 5.8%-18.1%) at 6 months, 20% (95% CI: 15%-26%) at 12 months, 23% (95%CI: 18%-29%) at 24 months and 23.3% (95%CI: 17.3%-30.7%) at ≥36 months. Interventions: There was not enough evidence to recommend one specific treatment (including cognitive behavioural therapy) over the others (including control conditions) to prevent the transition to psychosis in this population. Randomised controlled trials suggested that family interventions, cognitive remediation and fish oil supplementation may improve cognition, symptoms and functioning. At baseline, 30% of CHR-P adolescents were prescribed antipsychotics and 60% received psychotherapy. Conclusions: It is possible to detect and formulate a group-level prognosis in adolescents at risk for psychosis. Future interventional research is required.

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“…59 Numerous studies have found N1 amplitude deficits in schizophrenia, [60][61][62] which are thought to reflect impairment in auditory perceptual and attentional processing. 63,64 Two studies reported decreased N1 amplitudes in CHR patients compared with controls. 42,63 Moreover, van Tricht et al 65 found that N1 amplitude decreased after 18 months compared with baseline in CHR patients who converted to psychosis, but not in those who did not convert, suggesting that it is a marker of disease progression.…”

Section: Early Auditory Erpsmentioning

confidence: 99%

“…63,64 Two studies reported decreased N1 amplitudes in CHR patients compared with controls. 42,63 Moreover, van Tricht et al 65 found that N1 amplitude decreased after 18 months compared with baseline in CHR patients who converted to psychosis, but not in those who did not convert, suggesting that it is a marker of disease progression.…”

Section: Early Auditory Erpsmentioning

confidence: 99%

Event-Related Potentials in the Clinical High-Risk (CHR) State for Psychosis: A Systematic Review

et al. 2018

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There is emerging evidence that identification and treatment of individuals in the prodromal or clinical high-risk (CHR) state for psychosis can reduce the probability that they will develop a psychotic disorder. Event-related brain potentials (ERPs) are a noninvasive neurophysiological technique that holds promise for improving our understanding of neurocognitive processes underlying the CHR state. We aimed to systematically review the current literature on cognitive ERP studies of the CHR population, in order to summarize and synthesize the results, and their implications for our understanding of the CHR state. Across studies, amplitudes of the auditory P300 and duration mismatch negativity (MMN) ERPs appear reliably reduced in CHR individuals, suggesting that underlying impairments in detecting changes in auditory stimuli are a sensitive early marker of the psychotic disease process. There are more limited data indicating that an earlier-latency auditory ERP response, the N100, is also reduced in amplitude, and in the degree to which it is modulated by stimulus characteristics, in the CHR population. There is also evidence that a number of auditory ERP measures (including P300, MMN and N100 amplitudes, and N100 gating in response to repeated stimuli) can further refine our ability to detect which CHR individuals are most at risk for developing psychosis. Thus, further research is warranted to optimize the predictive power of algorithms incorporating these measures, which could help efforts to target psychosis prevention interventions toward those most in need.

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Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample

Cited by 22 publications

References 42 publications

The song of Anorexia Nervosa: a specific evoked potential response to musical stimuli in affected participants

The song of Anorexia Nervosa: a specific evoked potential response to musical stimuli in affected participants

Annual Research Review: Prevention of psychosis in adolescents – systematic review and meta‐analysis of advances in detection, prognosis and intervention

Event-Related Potentials in the Clinical High-Risk (CHR) State for Psychosis: A Systematic Review

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