Adolescent exposure to cocaine, amphetamine, and methylphenidate cross-sensitizes adults to methamphetamine with drug- and sex-specific effects

Shanks, Ryan A.; Ross, Jordan M.; Doyle, Hillary; Helton, Amanda; Picou, Brittany N.; Schulz, Jordyn; Tavares, Chris; Bryant, Sarah; Dawson, Bryan L.; Lloyd, Steven A.

doi:10.1016/j.bbr.2014.12.002

Cited by 29 publications

(20 citation statements)

References 79 publications

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“…Yet, despite this, female rats learned at a slower rate than males (discussed in Sex Differences , below). Long-lasting sensitization in adulthood following adolescent MPH exposure found by Shanks et al (2015) may also partially explain the pattern of results we observe here. Rats may be more reward sensitive in adulthood (to natural reinforcers, such as food) following chronic developmental exposure to MPH, which may attenuate or alter learning from feedback when such learning matters most to accurate performance, in early reversal learning (Izquierdo et al 2016).…”

Section: Discussionsupporting

confidence: 71%

“…Rodent females, like human females, mature earlier than males: on average the development of genitalia and activation of sexual organs occurs 4–8 d faster (Spear 2015). In addition to this difference, hormone signaling and pharmacokinetic differences between the sexes (Shanks et al 2015; Crawford et al 2011) may also have contributed to the sex differences we report here. Another plausible explanation for the sex differences in discrimination learning is basal anxiety differences in novel environments that may have affected the level of exploration in the operant chambers.…”

Section: Discussionmentioning

confidence: 84%

“…Some of the most commonly-prescribed are MPH for ADHD (Shanks et al 2015; Caprioli et al 2015; Crawford et al 2011; Gray et al 2007), and fluoxetine (FLX) for the treatment of Major Depression (Iñiguez et al 2010; Iñiguez et al 2014; Homberg et al 2011). MPH exhibits a similar pharmacological profile to amphetamines and cocaine, may modulate neurodevelopment (Grund et al 2007; Thanos et al 2007; Adriani et al 2006), and by extension, may impact learning and behavior mediated by corticostriatal circuitry.…”

Section: Introductionmentioning

confidence: 99%

“…There is evidence for long-term effects of adolescent MPH on adult locomotor behavior and addiction vulnerability. These effects include increased sensitization to later mAMPH (Shanks et al 2015), increased cocaine abuse risk (Jordan et al 2014), increased alcohol intake (Gill et al 2014), and increased cocaine-induced reward and behavioral sensitization (Achat-Mendes et al 2003) in adulthood (cf. Gray et al 2007).…”

Section: Introductionmentioning

confidence: 99%

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Sex differences, learning flexibility, and striatal dopamine D1 and D2 following adolescent drug exposure in rats

Izquierdo

Pozos

Torre

et al. 2016

Behavioural Brain Research

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Corticostriatal circuitry supports flexible reward learning and emotional behavior from the critical neurodevelopmental stage of adolescence through adulthood. It is still poorly understood how prescription drug exposure in adolescence may impact these outcomes in the long-term. We studied adolescent methylphenidate (MPH) and fluoxetine (FLX) exposure in rats and their impact on learning and emotion in adulthood. In Experiment 1, male and female rats were administered MPH, FLX, or saline (SAL), and compared with methamphetamine (mAMPH) treatment beginning in postnatal day (PND) 37. The rats were then tested on discrimination and reversal learning in adulthood. In Experiment 2, animals were administered MPH or SAL also beginning in PND 37 and later tested in adulthood for anxiety levels. In Experiment 3, we analyzed striatal dopamine D1 and D2 receptor expression in adulthood following either extensive learning (after Experiment 1) or more brief emotional measures (after Experiment 2). We found sex differences in discrimination learning and attenuated reversal learning after MPH and only sex differences in adulthood anxiety. In learners, there was enhanced striatal D1, but not D2, after either adolescent MPH or mAMPH. Lastly, also in learners, there was a sex x treatment group interaction for D2, but not D1, driven by the MPH-pretreated females, who expressed significantly higher D2 levels compared to SAL. These results show enduring effects of adolescent MPH on reversal learning in rats. Developmental psychostimulant exposure may interact with learning to enhance D1 expression in adulthood, and affect D2 expression in a sex-dependent manner.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sex differences, learning flexibility, and striatal dopamine D1 and D2 following adolescent drug exposure in rats

Izquierdo

Pozos

Torre

et al. 2016

Behavioural Brain Research

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“…Previous work revealed that when AMPH-exposed adolescents were given an AMPH challenge in adulthood, they exhibit sensitized locomotor responses (McPherson and Lawrence, 2006;Mathews et al, 2011;Labonte et al, 2012;Richetto et al, 2013;Shanks et al, 2015) and stereotypy (Hankosky et al, 2013;Sherrill et al, 2013). However, it was not previously demonstrated that dopamine receptor antagonists could partially reverse this sensitized response in adolescent-exposed rats or that D1 and D2 receptor-selective antagonists were similarly efficacious.…”

Section: Discussionmentioning

confidence: 88%

Effects of amphetamine exposure during adolescence on behavior and prelimbic cortex neuron activity in adulthood

Sherrill¹,

Gulley²

2018

Preprint

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Repeated exposure to psychostimulants during adolescence produces long-lasting changes in behavior that may be mediated by disrupted development of the mesocorticolimbic dopamine system. Here, we tested this hypothesis by assessing the effects of amphetamine (AMPH) and dopamine receptor-selective drugs on behavior and neuron activity in the prelimbic region of the medial prefrontal cortex (PFC). Adolescent male, Sprague-Dawley rats were given saline or 3 mg/kg AMPH between postnatal day (P) 27 and P45. In Experiment 1, locomotor behavior was assessed during adulthood following challenges with a dopamine D1 (SKF 82958) or D2 (quinpirole) receptor-selective agonist. In Experiment 2, pre-exposed rats were challenged during adulthood with AMPH and a D1 (SKF 83566) or D2 (eticlopride) receptor-selective antagonist. In Experiment 3, the activity of putative pyramidal cells in the prelimbic cortex was recorded as rats behaved in an open-field arena before and after challenge injections with AMPH and one of the antagonists. We found that compared to controls, adolescent pre-exposed rats were more sensitive to the stimulant effects of AMPH and the dopamine receptor agonists, as well as to the ability of the antagonists to reverse AMPH-induced stereotypy. Prelimbic neurons from AMPH pre-exposed rats were also more likely to respond to an AMPH challenge in adulthood, primarily by reducing their activity, and the antagonists reversed these effects. Our results suggest that exposure to AMPH during adolescence leads to enduring adaptations in the mesocorticolimbic dopamine system that likely mediate heightened response to the drug during adulthood.

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Rodent Models of Methamphetamine Misuse: Mechanisms of Methamphetamine Action and Comparison of Different Rodent Paradigms

Hasan

Abdelhady

Haidar

et al. 2019

Methods in Molecular Biology

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Adolescent exposure to cocaine, amphetamine, and methylphenidate cross-sensitizes adults to methamphetamine with drug- and sex-specific effects

Cited by 29 publications

References 79 publications

Sex differences, learning flexibility, and striatal dopamine D1 and D2 following adolescent drug exposure in rats

Sex differences, learning flexibility, and striatal dopamine D1 and D2 following adolescent drug exposure in rats

Effects of amphetamine exposure during adolescence on behavior and prelimbic cortex neuron activity in adulthood

Rodent Models of Methamphetamine Misuse: Mechanisms of Methamphetamine Action and Comparison of Different Rodent Paradigms

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