Adolescent exposure to a solid high-fat, high-sugar ‘cafeteria’ diet leads to more pronounced changes in metabolic measures and gut microbiome composition than liquid sugar in female rats

Kendig, Michael D.; Hasebe, Kyoko; McCague, Róisín; Lee, Frances; Leigh, Sarah‐Jane; Arnold, Ria; Morris, Margaret J.

doi:10.1016/j.appet.2022.105973

Cited by 9 publications

(2 citation statements)

References 62 publications

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“…Prolonged consumption of UPFs among obesity-prone rats has also been found to cause reduced excitability of nucleus accumbens core neurons, which is suggestive of altered dopaminergic reward responses and has been similarly demonstrated with chronic cocaine exposure [ 41 , 42 ]. Another study demonstrated that prolonged UPF consumption alters the gut microbiome in a manner that creates an abundance of microbes implicated in obesity and metabolic disease [ 43 ]. Across these studies, addiction-like alterations were not found to occur when obesity-prone rats consumed their nutritionally balanced chow [ 38 – 43 ].…”

Section: Recent Research On the Biological Underpinnings Of Upf Addic...mentioning

confidence: 99%

“…Another study demonstrated that prolonged UPF consumption alters the gut microbiome in a manner that creates an abundance of microbes implicated in obesity and metabolic disease [43]. Across these studies, addiction-like alterations were not found to occur when obesity-prone rats consumed their nutritionally balanced chow [38][39][40][41][42][43].…”

Section: Recent Research On the Biological Underpinnings Of Upf Addic...mentioning

confidence: 99%

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Ultra-Processed Food Addiction: A Research Update

LaFata,

Allison,

Audrain-McGovern

et al. 2024

Curr Obes Rep

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Purpose of Review Detail recent advancements in the science on ultra-processed food (UPF) addiction, focusing on estimated prevalence rates and emerging health disparities; progress towards identifying biological underpinnings and behavioral mechanisms; and implications for weight management. Recent Findings Notable developments in the field have included: (1) estimating the global prevalence of UPF addiction at 14% of adults and 15% of youths; (2) revealing health disparities for persons of color and those with food insecurity; (3) observing altered functioning across the brain-gut-microbiome axis; (4) providing early evidence for UPF withdrawal; and (5) elucidating poorer weight management outcomes among persons with UPF addiction. Summary The breadth of recent work on UPF addiction illustrates continued scientific and public interest in the construct and its implications for understanding and treating overeating behaviors and obesity. One pressing gap is the lack of targeted interventions for UPF addiction, which may result in more optimal clinical outcomes for this underserved population.

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