Admission fasting plasma glucose is associated with in-hospital outcomes in patients with acute coronary syndrome and diabetes: findings from the improving Care for Cardiovascular Disease in China - Acute Coronary Syndrome (CCC-ACS) project

Ye, Nan; Yang, Lijiao; Wang, Guoqin; Bian, Weijing; Xu, Fang; Ma, Changsheng; Zhao, Dong; Liu, Jing; Hao, Yongchen; Li, Jun; Yang, Na; Cheng, Hong

doi:10.1186/s12872-020-01662-3

Cited by 8 publications

(5 citation statements)

References 30 publications

(32 reference statements)

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“…Considering the definition of FG used in these studies, it seems to be an alternative index for ABG. However, FG within 24 h of admission was reported to be associated with both increased short and long-term mortalities only in diabetic patients with ACS ( 31 – 33 ).…”

Section: Defining Sih In the Context Of Acsmentioning

confidence: 99%

Stress Induced Hyperglycemia in the Context of Acute Coronary Syndrome: Definitions, Interventions, and Underlying Mechanisms

Guo

Feng

et al. 2021

Front. Cardiovasc. Med.

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Elevation of glucose level in response to acute coronary syndrome (ACS) has been recognized as stress induced hyperglycemia (SIH). Plenty of clinical studies have documented that SIH occurs very common in patients hospitalized with ACS, even in those without previously known diabetes mellitus. The association between elevated blood glucose levels with adverse outcome in the ACS setting is well-established. Yet, the precise definition of SIH in the context of ACS remains controversial, bringing confusions about clinical management strategy. Several randomized trials aimed to evaluate the effect of insulin-based therapy on outcomes of ACS patients failed to demonstrate a consistent benefit of intensive glucose control. Mechanisms underlying detrimental effects of SIH on patients with ACS are undetermined, oxidative stress might play an important role in the upstream pathways leading to subsequent harmful effects on cardiovascular system. This review aims to discuss various definitions of SIH and their values in predicting adverse outcome in the context of ACS, as well as the effect of intensive glucose control on clinical outcome. Finally, a glimpse of the underlying mechanisms is briefly discussed.

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Section: Defining Sih In the Context Of Acsmentioning

confidence: 99%

Stress Induced Hyperglycemia in the Context of Acute Coronary Syndrome: Definitions, Interventions, and Underlying Mechanisms

Guo

Feng

et al. 2021

Front. Cardiovasc. Med.

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“…Given such diverse study findings, the most appropriate glycemic status indicator remains to be established. Some answers come from a Chinese study of 7762 patients with ACS and diabetes that looked at patients with inconsistencies between the two most common parameters used to determine glycemic status, namely FPG and HbA1c [ 47 ]. Inconsistencies were defined as either both HbA1c ≥ 48 mmol/mol and FPG < 7.0 mmol/L, or both HbA1c < 48 mmol/mol and FPG ≥ 7.0 mmol/L.…”

Section: Resultsmentioning

confidence: 99%

“…The study showed that inconsistencies in FPG and HbA1c levels result in two patient categories with different in-hospital outcomes. After adjusting for confounding factors, patients in the increased FPG group were more likely to suffer adverse CV outcomes compared with those in the increased HbA1c group [ 47 ]. Thus, in the setting of ACS, among diabetic patients with HbA1c-FPG discrepancy, those with increased FPG are at a higher risk of in-hospital adverse outcomes compared to those with increased HbA1c [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

Emerging Biomarkers for Predicting Clinical Outcomes in Patients with Heart Disease

Pál

Bărcuțean

Lupu

et al. 2023

Life

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Cardiovascular disease is most frequently caused by the development and progression of atherosclerosis. When coronary arteries are afflicted, and the stenoses caused by atherosclerotic plaques are severe enough, the metabolic supply-and-offer balance is disturbed, leading to myocardial ischemia. If atherosclerotic plaques become unstable and local thrombosis develops, a myocardial infarction occurs. Sometimes, myocardial ischemia and infarction may result in significant and irreversible heart failure. To prevent severe complications, such as acute coronary syndromes and ischemia-related heart failure, extensive efforts have been made for developing biomarkers that would help identify patients at increased risk for cardiovascular events. In this two-part study, we attempted to provide a review of existing knowledge of blood biomarkers that may be used in this setting. The first part of this work was dedicated to conventional biomarkers, which are already used in clinical practice. In the second part, here presented, we discuss emerging biomarkers which have not yet become mainstream.

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“…Semua penelitian ini menggunakan sampel manusia (Tabel 2). [12][13][14][15][16][17][18][19][20] Pembahasan Kadar gula darah yang tidak terkontrol pada pasien DM tipe 2 berkaitan dengan metabolisme glukosa yang abnormal yang dapat meningkatkan kecepatan pembentukan plak aterosklerosis yang kemudian mengalami trombosis dan ruptur, serta gangguan fungsi endotel yang menyebabkan jejas pada pembuluh darah. 15,21,22 Beberapa penelitian yang telah di-review secara teliti menunjukkan bahwa kadar gula darah tidak terkontrol merupakan presentasi yang umum di kalangan pasien dengan infark miokardiak akut dan dapat menurunkan fungsi sistolik, sampai mengarah kepada hal yang fatal, yaitu kematian.…”

Section: Hasilunclassified

Scoping Review: Pengaruh Kadar Gula Darah tidak Terkontrol terhadap Komplikasi Makrovaskular pada Pasien Diabetes Melitus Tipe 2

2021

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Diabetes melitus (DM) tipe 2 adalah gangguan metabolik karena tubuh mampu menghasilkan insulin, namun tidak dalam kadar normal atau tidak dapat berespons terhadap efek insulin (resistensi insulin) sehingga menyebabkan hiperglikemia. Jika kadar gula darah tidak dikontrol dengan baik maka akan dapat menyebabkan komplikasi kronis berupa mikrovaskular seperti penyakit mata, neuropati dan nefropati, serta makrovaskular seperti penyakit arteri koroner, arteri perifer, dan serebrovaskular. Pada tahun 2013, riset menunjukkan prevalensi penderita DM di Indonesia tinggi, terutama di Provinsi Sulawesi Tengah. Tujuan mengetahui komplikasi makrovaskular pada penderita diabetes melitus tipe 2 dengan kadar gula darah tidak terkontrol. Metode penelitian: Scoping review dengan mengidentifikasi, menganalisis, dan mengevaluasi suatu karya tulis ilmiah yang diterbitkan dalam rentang waktu 10 tahun terakhir yang dilakukan selama September—Desember 2020. Pencarian sistematis dilakukan melalui situs database yaitu Pubmed, Springer Link, dan Proquest. Sesuai dengan kriteria inklusi dan tidak termasuk eksklusi serta dilakukan skrining menggunakan kriteria kelayakan pada PRISMA dan disajikan dalam bentuk tabel hasil penelitian berisi uraian artikel penelitian yang telah di-review (9 artikel). Simpulan: Sembilan artikel menyatakan terdapat pengaruh kadar gula darah tidak terkontrol terhadap kemunculan komplikasi makrovaskular berupa penyakit arteri koroner, arteri perifer dan serebrovaskular pada pasien diabetes melitus tipe 2. Kadar gula darah tidak terkontrol berkaitan dengan pembentukan plak aterosklerosis serta gangguan fungsi endotel sehingga pasien dengan miokardiak infark, gangren, iskemik strok merupakan presentasi yang umum pada pasien dengan kadar gula darah tidak terkontrol. The Effect of Uncontrolled Blood Sugar Levels on Macrovascular Complications in Type 2 Diabetes Mellitus Patients: Scoping ReviewDiabetes mellitus (DM) type 2 is a metabolic disorder in which the body is able to produce insulin but not in normal levels or cannot respond to the effects of insulin (insulin resistance), causing hyperglycemia. If blood sugar levels are not properly controlled, it can lead to chronic complications in the form of microvascular diseases such as eye diseases, neuropathy and nephropathy and macrovascular diseases such as coronary artery disease, peripheral arteries and cerebrovascular. In 2013, research showed the high prevalence of DM sufferers in Indonesia, especially in the province of Central Sulawesi. Objective: To see the emergence of macrovascular complications in type 2 diabetes mellitus patietns with uncontrolled blood sugar levels. Research method: Scoping review by identifying, analyzing and evaluating a scientific paper published within the last 10 years, conducted in September—December 2020. Systematic searches were carried out through database sites, i.e Pubmed, Springer Link and Proquest. In accordance with inclusion and exclusion criteria, and screening was carried out using the PRISMA eligibility criteria and presented in the form of a research table containing a reviewed descriptions of research articles (9 articles). Conclusion: Nine articles stated that there was an effect of uncontrolled blood sugar levels on the emergence of macrovascular complications in the form of coronary artery disease, peripheral arteries and cerebrovascular disease in patients with type 2 diabetes mellitus. Uncontrolled blood sugar levels were associated with atherosclerotic plaque formation and impaired endothelial function. Myocardiac infarction, gangrene, ischemic stroke are common presentations in patients with uncontrolled blood sugar levels.

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Admission fasting plasma glucose is associated with in-hospital outcomes in patients with acute coronary syndrome and diabetes: findings from the improving Care for Cardiovascular Disease in China - Acute Coronary Syndrome (CCC-ACS) project

Cited by 8 publications

References 30 publications

Stress Induced Hyperglycemia in the Context of Acute Coronary Syndrome: Definitions, Interventions, and Underlying Mechanisms

Stress Induced Hyperglycemia in the Context of Acute Coronary Syndrome: Definitions, Interventions, and Underlying Mechanisms

Emerging Biomarkers for Predicting Clinical Outcomes in Patients with Heart Disease

Scoping Review: Pengaruh Kadar Gula Darah tidak Terkontrol terhadap Komplikasi Makrovaskular pada Pasien Diabetes Melitus Tipe 2

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