Administration of recombinant human FSH (solution in cartridge) with a pen device in women undergoing ovarian stimulation

Patient and nurse evaluation of recombinant human follicle-stimulating hormone administration methods: comparison of two follitropin injection pens

“…The Puregon* pen, introduced 5 years ago, is a reusable device supplied with cartridges of r-hFSH (follitropin beta) solution. It is considered easy to use 18,19 , and has been shown to be a more convenient and less painful method of administration compared with conventional syringes and vials 20,21 .…”

A comparison of the efficacy, tolerability, and convenience of two formulations of follitropin-α in Iranian woman undergoing intracytoplasmic sperm injection cycles

“…Patient-friendly protocols are designed to relieve some of the stress associated with infertility, as well as the patients' anxiety with regard to administration of medications (6). In comparison to conventional syringes, a pen injector has been shown to be better accepted by diabetes patients, as it offers easier, safer, more accurate, and more discrete insulin injection (8,9).…”

“…In two separate studies, Kettel et al (11) showed 100% and Pang et al (6) showed 98.3% of subjects rated their overall experience of self-administrating follitropin-b with the pen device as ''very good'' to ''good.'' Overall convenience in this study was high, but there was no statistically significant difference between two groups (P¼.248).…”

“…Clear glass cartridges containing Gonal-F solution are designed for subcutaneous injection preassembled in a disposable pen (5). Several studies have indicated that patients' satisfaction is significantly higher when the medication is used by means of a pen device; however, all of these studies have been conducted in developed countries, and there is no study in developing countries (1,(5)(6)(7). Self-injection of medications is not a common practice among Iranian patients, and in most cases injections are done by either nurses or technicians.…”

Gonadotropin preparations: past, present, and future perspectives

“…The conversion factor suggested for these products is that 75 IU of FSH assessed by the Steelman-Pohley assay corresponds to between 5.0 and 5.5 mg of a fill-by-mass product. Delivery systems for recombinant FSH products include pen-shaped administration devices that either are pre-filled or can be adjusted to deliver variable amounts of gonadotropin contained in vials (32). All preparations are packaged as lyophilized powder with the exception of the liquid formulations found in cartridges or pens.…”