A comparison of the efficacy, tolerability, and convenience of two formulations of follitropin-α in Iranian woman undergoing intracytoplasmic sperm injection cycles

The redesigned follitropin alfa pen injector: results of the patient and nurse human factors usability testing

“…Thus, patients and nurses have to learn how to use several different devices for the administration of treatment. Several reports indicate that patients undergoing infertility treatment find pen injectors simpler and easier to use than other administration methods [3,[7][8][9]19]. Furthermore, the ease of teaching and learning of the redesigned follitropin a pen injector has previously been assessed in 73 women with infertility and 28 specialist nurses [14].…”

“…With the availability of gonadotropin formulations that can be administered subcutaneously, most patients are now able to perform their own injections after training by their healthcare provider. Several publications report that infertile patients find pen injectors simpler and easier to use than other administration methods [3,[7][8][9].…”

Drug tolerability in assisted reproduction techniques: a longitudinal study

“…Interestingly, one study hypothesized that pen injectors may require greater education of the patients [Chen et al 2009)]. This along with several other factors, such as the pen enabling self-administration of the drug [Pang 2003;Craenmeher et al 2001] with greater convenience and comfort, especially for patients taking several drugs [Sedbon et al 2006], suggests why many studies have observed a greater acceptance of the use of pen injectors on the part of the patients [Welcker et al 2010;Gibreel and Bhattacharya 2010;Rama Raju et al 2008;Aghssa et al 2008;Weiss 2007;Kettle et al 2004].…”

Gonadotropin in Assisted Reproduction: An Evolution Perspective

“…In 2001, follitropin beta has been made available as a ready-to-use solution with a cartridge presentation for administration with a pen device [78]. This injector was an adapted insulin pen, which has been better accepted by diabetes patients in comparison with conventional syringes [114,115]. Importantly, the injector was reusable and allowed follitropin beta self-administration in precise individualized dosing ranging from 25 to 450 IU [78].…”