Administration of phytosterols isolated from Aloe vera gel reduce visceral fat mass and improve hyperglycemia in Zucker diabetic fatty (ZDF) rats

Misawa, Eriko; Tanaka, Miyuki; Nomaguchi, Kouji; Yamada, Muneo; Toida, Tomohiro; Takase, Mitsunori; Iwatsuki, Keiji; Kawada, Teruo

doi:10.1016/j.orcp.2008.06.002

Cited by 64 publications

(57 citation statements)

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“…Additionally, we found that the administration of two Aloe -sterols (lophenol and cycloartanol) could improve hyperglycemia and glucose intolerance, and reduce visceral fat mass without weight loss in Zucker diabetic fatty (ZDF; ZDF/Crl-Lepr fa (fa/fa)) rats ( 17 ). Furthermore, we demonstrated that these Aloe -sterols activated transcription of PPARs using a luciferase reporter assay ( 18 ).…”

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confidence: 86%

Administration of Dried Aloe vera Gel Powder Reduced Body Fat Mass in Diet-Induced Obesity (DIO) Rats

Misawa

Tanaka

Nabeshima

et al. 2012

J Nutr Sci Vitaminol

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SummaryThe aim of the present study was to investigate the anti-obesity effects of Aloe vera gel administration in male Sprague-Dawley (SD) rats with diet-induced obesity (DIO). SD rats at 7 wk of age were fed either a standard diet (10 kcal% fat) (StdD) or high-fat (60 kcal% fat) diet (HFD) during the experimental period. Four weeks after of HFD-feeding, DIO rats (11 wk of age) were orally administered with two doses of Aloe vera gel powder (20 and 200 mg/kg/d) for 90 d. Body weights (g) and body fat (%) of HFD fed rats were significantly higher than those of StdD-fed rats. Although a modest decrease of body weight (g) was observed with the administration of dried Aloe vera gel powder, both subcutaneous and visceral fat weight (g) and body fat (%) were reduced significantly in Aloe vera gel-treated rats. Serum lipid parameters elevated by HFD were also improved by the Aloe vera gel treatment. The oxygen consumption (VO 2 ), an index of energy expenditure, was decreased in HFD-fed rats compared with that in StdD-fed rats. Administration of Aloe vera gel reversed the change in VO 2 in the HFD-fed rats. These results suggest that intake of Aloe vera gel reduced body fat accumulation, in part, by stimulation of energy expenditure. Aloe vera gel might be beneficial for the prevention and improvement of diet-induced obesity.

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confidence: 86%

Administration of Dried Aloe vera Gel Powder Reduced Body Fat Mass in Diet-Induced Obesity (DIO) Rats

Misawa

Tanaka

Nabeshima

et al. 2012

J Nutr Sci Vitaminol

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“…Active components present in Aloe vera also help in lowering high blood pressure. This makes Aloe vera extremely suitable for wide scale treatment to all diabetic conditions (Misawa et al 2008). Aloe vera helps in reducing serum cholesterol and tri-glycerides and increasing level of high density lipoprotein cholesterol (HDL-C).…”

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confidence: 99%

Hypoglycemic and hypolipidemic effect of Aloe vera L. in non-insulin dependent diabetics

2011

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Ninety non-insulin dependent diabetic subjects were selected from Punjab Agricultural University and Civil hospitals of Ludhiana. The selected subjects were divided into three groups viz. Group I, II and III having thirty subjects each. The subjects of group I were not given any treatment. The subjects of group II and III were supplemented with 100 mg and 200 mg of Aloe vera L. gel powder respectively for a period of 3 months and supplementation was continued along with nutrition counselling for the next 3 months. The nutrition education was given for 3 months after 15 days interval to the subjects of group II and III through individual and group contact. The blood glucose and lipid profile were analyzed. The blood pressure of the subjects was also measured. It was seen that there was a significant (p≤0.01) reduction in fasting blood glucose level by 11.4% and 15.4% and post prandial glucose level 18.5% and 27.8% in the subjects of group II and III respectively after the study. Significant (p≤ 0.01) reduction in total cholesterol 8.6% and 10.1%, triglycerides 9.6% and 12.2%, low density lipoprotein cholesterol (LDL-C) 12.8% and 14.6%, very low density lipoprotein cholesterol (VLDL-C) 9.6% and 12.2% and an increase in high density lipoprotein cholesterol (HDL-C) 7.3% and 9.4% was observed in the subjects of group II and III respectively. The ratio of total cholesterol to HDL-C reduced from 5.6 to 4.8 and 6.1 to 5.0 and LDL-C to HDL-C from 3.7 to 3.0 and 4.1 to 3.1 in the subjects of group II and III respectively after the study. There was also a significant decrease (p≤0.01) in the blood pressure of the subjects of group II and III and a non significant decrease (p≤0.01) was seen in the subjects of group I. With the intervention of Aloe vera L., significant reduction was observed in blood glucose, lipid profile and blood pressure of the diabetic patients.

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“…Recent epidemiological studies have also reported that obesity may be a major risk factor in many cancers, especially cancers of the colon and breast (Sung et al, 2011). Lophenol and cycloartanol, two kinds of Aloe-sterols, reduced visceral fat accumulation and improved hyperlipidemia and hyperglycemia in ZDF rats fed a high-fat diet (Misawa et al, 2008). Furthermore, these of Aloe-sterols altered the expression levels of genes related to glucose and lipid metabolism, and ameliorated obesity-associated metabolic disorders DOI:http://dx.doi.org/10.7314/APJCP.2015.16.2.683 Dietary Aloe Vera Inhibits Azoxymethane-Induced Colorectal Aberrant Crypt Foci in Mice Fed a High-Fat Diet. in ZDF rats given a high-fat diet (Misawa et al, 2012b).…”

Section: Discussionmentioning

confidence: 99%

“…The administration of lophenol and cycloartanol have been shown to improve hyperglycemia and glucose metabolism and also reduced intra-abdominal fat accumulation in Zucker diabetic fatty (ZDF) rats fed a high-fat diet (Misawa et al, 2008). These findings have been attributed to the down-regulation of fatty acid synthesis and slight up-regulation of fatty acid oxidation in the liver with the administration of lophenol and cycloartanol (Misawa et al, 2008), thereby suggesting that Aloe vera gel could reduce the higher risk of colon cancer associated with fat intake as reported by epidemiological studies (Day et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Dietary Aloe Vera Gel Powder and Extract Inhibit Azoxymethane-induced Colorectal Aberrant Crypt Foci in Mice Fed a High-fat Diet

Chihara

Shimpo

Kaneko

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Aloe vera gel exhibits protective effects against insulin resistance as well as lipid-lowering and anti-diabetic effects. The anti-diabetic compounds in this gel were identified as Aloe-sterols. Aloe vera gel extract (AVGE) containing Aloe-sterols has recently been produced using a new procedure. We previously reported that AVGE reduced large-sized intestinal polyps in Apc-deficient Min mice fed a high fat diet (HFD), suggesting that Aloe vera gel may protect against colorectal cancer. In the present study, we examined the effects of Aloe vera gel powder (AVGP) and AVGE on azoxymethane-induced colorectal preneoplastic aberrant crypt foci (ACF) in mice fed a HFD. Male C57BL/6J mice were given a normal diet (ND), HFD, HFD containing 0.5% carboxymethyl cellulose solution, which was used as a solvent for AVGE (HFDC), HFD containing 3% or 1% AVGP, and HFDC containing 0.0125% (H-) or 0.00375% (L-) AVGE. The number of ACF was significantly lower in mice given 3% AVGP and H-AVGE than in those given HFD or HFDC alone. Moreover, 3% AVGP, H-AVGE and L-AVGE significantly decreased the mean Ki-67 labeling index, assessed as a measure of cell proliferation in the colonic mucosa. In addition, hepatic phase II enzyme glutathione S-transferase mRNA levels were higher in the H-AVGE group than in the HFDC group. These results suggest that both AVGP and AVGE may have chemopreventive effects on colorectal carcinogenesis under the HFD condition. Furthermore, the concentration of Aloe-sterols was similar between 3% AVGP and H-AVGE, suggesting that Aloe-sterols were the main active ingredients in this experiment.

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Administration of phytosterols isolated from Aloe vera gel reduce visceral fat mass and improve hyperglycemia in Zucker diabetic fatty (ZDF) rats

Cited by 64 publications

References 24 publications

Administration of Dried Aloe vera Gel Powder Reduced Body Fat Mass in Diet-Induced Obesity (DIO) Rats

Administration of Dried Aloe vera Gel Powder Reduced Body Fat Mass in Diet-Induced Obesity (DIO) Rats

Hypoglycemic and hypolipidemic effect of Aloe vera L. in non-insulin dependent diabetics

Dietary Aloe Vera Gel Powder and Extract Inhibit Azoxymethane-induced Colorectal Aberrant Crypt Foci in Mice Fed a High-fat Diet

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