Administration of high dose eicosapentaenoic acid enhances anti-inflammatory properties of high-density lipoprotein in Japanese patients with dyslipidemia

Effects of the Addition of Eicosapentaenoic Acid to Strong Statin Therapy on Inflammatory Cytokines and Coronary Plaque Components Assessed by Integrated Backscatter Intravascular Ultrasound

“…In addition, EPA has been reported to transform dysfunctional high-density lipoprotein to the functional form. 53 Additional EPA therapy may reduce the residual risk of strong statin therapy in patients with stable angina. The results suggest the usefulness of EPA for secondary prevention in these patients.…”

Unsolved Antiatherogenic Mechanism of n-3 Polyunsaturated Fatty Acids

“…14 Previously, the same research group demonstrated similar antiatherogenic effects in dyslipidemic patients who were orally administered highdose EPA (1.8 g). 15 In that human study, EPA/arachidonic acid ratios in HDL particles before and after EPA therapy were estimated as 0.4 and 1.25, respectively. 15 The EPA/ arachidonic acid ratios of rHDL (low, 20; intermediate, 80; high, 100) in the present study were 4.9, 72.9, and 257.0, respectively.…”

Eicosapentaenoic Acid-Enriched High-Density Lipoproteins Exhibit Anti-Atherogenic Properties

“…15 Briefly, human umbilical vein endothelial cells (HUVECs) were plated in serum-deprived RPMI1640 medium supplemented with 1% fetal bovine serum (FBS). HUVECs were incubated with RPMI1640 supplemented with 1% FBS, 100 μg/mL rHDL and 10 ng/mL TNF-α for 4 h. VCAM-1 expression was measured by using real-time polymerase chain reaction (PCR).…”

“…12- 14 In addition, we have recently demonstrated that administration of high-dose EPA enhances the anti-inflammatory properties of HDL in Japanese patients with dyslipidemia. 15 Evidence favors the possibility that EPA plays crucial roles in the prevention of cardiovascular diseases; 16 however, the molecular mechanisms by which EPA exerts its antiatherosclerotic effects remain unclear.…”

“…15 In addition, it is widely recognized that anti-inflammatory effects of E-series resolvins are nearly 1,000-fold greater than those of EPA. 22 Taken together, dietary EPA consumption that improves cardiovascular function may be associated with RvE3 production from the EPA-incorporated HDL.…”