Administration of estradiol and progesterone modulate the activities of antioxidant enzyme and aminotransferases in naturally menopausal rats

Moorthy, K.; Sharma, Deepak; Basir, Seemi Farhat; Baquer, Najma Zaheer

doi:10.1016/j.exger.2005.01.004

Cited by 82 publications

(48 citation statements)

References 42 publications

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“…This observation is supported by the earlier findings of Kumar et al 2011 [5]. Earlier data from a previous study showed decreased levels of E2 at 12 and 24 months as compared to the 3-month rats [26].…”

Section: Discussionsupporting

confidence: 82%

Effects of tachykinin neuropeptide NKB and Aβ (25-35) on antioxidant enzymes status in 17β estradiol treated aging female rats

Jha¹,

Ali²,

Pandey³

et al. 2013

AAR

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Aging is the leading risk factor for neurodegenerative diseases and oxidative stress involved in the pathophysiology of these diseases. These changes increase during menopausal condition in females when the level of estradiol is decreased. The aim of the present study was to determine the effect of tachykinin neuropeptide, Neurokinin B (NKB) and Amyloid beta fragment Aβ (25 -35) on 17β estradiol (E2) treated aging female rat synaptosomes of different age groups. Aging brain functions were assayed by measuring the activities of antioxidant enzymes-superoxide dismutase (SOD) and monoamine oxidase (MAO) with neuropeptides. An in-vitro incubation of Aβ (25 -35) in E2 treated brain synaptosomes showed toxic effects on all the parameters. However, NKB and NKB combined with Aβ (25 -35) showed stimulating effects in E2 treated rat brain synaptosomes. In the present study, an increase in activity of SOD and decrease in the level of MAO, in the presence of NKB and combined NKB and Aβ in E2 treated brain synaptosomes of aging rats. This study elucidates that treatment of NKB and Aβ with E2 in combination exerts more protective influence than their individual application, against excitotoxicity in age related changes.

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Section: Discussionsupporting

confidence: 82%

Effects of tachykinin neuropeptide NKB and Aβ (25-35) on antioxidant enzymes status in 17β estradiol treated aging female rats

Jha¹,

Ali²,

Pandey³

et al. 2013

AAR

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“…This phenomenon may be due to the possible interaction of female sex hormone with antioxidant vitamins. Estradiol is an antioxidant, similar to vitamin E, which can modify oxidative stress and renal toxicity (49,50). In another study, Nematbakhsh et al have shown that in the presence of estradiol, vitamin C cannot decrease cisplatin-induced nephrotoxicity.…”

Section: The Effect Of Gentamicin On Kidney Mda Level and Kidney Sod mentioning

confidence: 99%

“…About antioxidants, other studies have shown a synergism effect on the administration of vitamin E with probucol (51) and selenium on gentamicin nephrotoxicity (25). Moorthy et al (50) documented that treatment with sildenafil decreased gentamicin nephrotoxicity and improved renal functioning. Another article reported that low doses of pomegranate flower extract improved gentamicin toxicity and decreased BUN urea and Cr (23).…”

Section: The Effect Of Gentamicin On Kidney Mda Level and Kidney Sod mentioning

confidence: 99%

Gender differences in response to vitamin E and C in gentamicin induced nephrotoxicity in Wistar rats

Safari¹,

Miri²,

Ghofran³

et al. 2017

J Nephropathol

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Background: Nephrotoxicity is the most recognized side effect of gentamicin. Vitamin E and vitamin C demonstrate their effective role in the prevention of nephrotoxicity. Likewise, previous studies have suggested that women have low risk of end-stage renal disease at premenopausal period. Objectives: This study aims to investigate the possibility of any gender difference in response to antioxidant effects vitamins E and C in gentamicin-induced nephrotoxicity. Materials and Methods: Wistar rats were randomly assigned to 6 groups each including both male and female rats. The first and second groups received saline (control group) and almond oil, the third group received gentamicin. The fourth group received a regular dose of gentamicin + vitamin E. Similarly, the fifth group received a regular dose of gentamicin + vitamin C. The sixth group received a dose of gentamicin + vitamin C and E simultaneously constantly. This protocol continued for 9 days. Results: Gentamicin increased significantly urea, creatinine (Cr) and malondialdehyde (MDA), but it decreased superoxidase dismutase (SOD) level (P < 0.05). Treatment with antioxidant vitamins improved urea, creatinine, MDA, and SOD serum level significantly in both genders (P <0.05). Likewise, kidney MDA level enhanced significantly (P <0.05) and treatment with antioxidant vitamins reduced MDA level too (P <0.05). Gentamicin decreased kidney SOD activity in male and female rats (P <0.05). However, treatment with antioxidant vitamins did not improve its level in male rats, while in female rats, vitamins E and C compensated for kidney SOD activity. Conclusions: Antioxidant vitamins modified gentamicin-induced nephrotoxicity in both genders, with some difference in response to vitamins E and C between the genders, that was higher in female rats.

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“…Estrogen replacement therapy improves lipoprotein profiles in postmenopausal women, but this accounts for less than half of the cardioprotective effects of estrogen replacement therapy. The cardioprotective benefits of estrogens include a positive impact on plasma lipids (increased high density lipoprotein (HDL), decreased total cholesterol, triglycerides, low density lipoprotein (LDL), and LDL oxidation) (Skafar et al, 1997, Moorthy et al, 2004, anti-platelet and antioxidant effects and preservation of endothelium-mediated vasodilatation (Maxwell, 1998;Moorthy et al, 2005). These effects may be mediated via genomic and/or nongenomic mechanisms (Skafar et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Hypercholesterolemia and 3-hydroxy-3-methylglutaryl coenzyme A reductase regulation in aged female rats

Trapani¹,

Violo²,

Pallottini³

2010

Experimental Gerontology

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT 2 AbstractCoronary heart disease is less prevalent in pre-menopausal women than in men, but increases at the onset of menopause. This delay is due to estrogen protective effects. The rise of cholesterolemia is one of the main risk factors for coronary disease. Since 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is the rate-limiting enzyme of the cholesterol biosynthetic pathway, it plays a pivotal role in cholesterol homeostasis maintenance. Aim of this study is to investigate whether HMGR is involved in the cholesterolemia increase that occurs during aging, and to consider its potential role as a target for estrogen protective effects. "In vivo" studies have been performed using the livers of 12-month-old female rats (whose estrogen level decrease is comparable to the one detected at the occurrence of human estropause), 12-month-old female rats treated with 17--estradiol, and 3-month-old untreated male and female rats. The results indicated hypercholesterolemic status and a significant increase of HMGR activity according to a reduced activation of AMPK detected in treated rats compared to controls. Furthermore, 17-estradiol treatment reduced HMGR activity restoring AMPK activation. These findings highlight the correlation between estrogen and HMGR short-term regulation, and suggest the presence of another mechanism underlying the protective role of estrogen in age-related diseases.

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Administration of estradiol and progesterone modulate the activities of antioxidant enzyme and aminotransferases in naturally menopausal rats

Cited by 82 publications

References 42 publications

Effects of tachykinin neuropeptide NKB and A<i>β</i> (25-35) on antioxidant enzymes status in 17<i>β</i> estradiol treated aging female rats

Effects of tachykinin neuropeptide NKB and A<i>β</i> (25-35) on antioxidant enzymes status in 17<i>β</i> estradiol treated aging female rats

Gender differences in response to vitamin E and C in gentamicin induced nephrotoxicity in Wistar rats

Hypercholesterolemia and 3-hydroxy-3-methylglutaryl coenzyme A reductase regulation in aged female rats

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Administration of estradiol and progesterone modulate the activities of antioxidant enzyme and aminotransferases in naturally menopausal rats

Cited by 82 publications

References 42 publications

Effects of tachykinin neuropeptide NKB and A&lt;i&gt;β&lt;/i&gt; (25-35) on antioxidant enzymes status in 17&lt;i&gt;β&lt;/i&gt; estradiol treated aging female rats

Effects of tachykinin neuropeptide NKB and A&lt;i&gt;β&lt;/i&gt; (25-35) on antioxidant enzymes status in 17&lt;i&gt;β&lt;/i&gt; estradiol treated aging female rats

Gender differences in response to vitamin E and C in gentamicin induced nephrotoxicity in Wistar rats

Hypercholesterolemia and 3-hydroxy-3-methylglutaryl coenzyme A reductase regulation in aged female rats

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Effects of tachykinin neuropeptide NKB and A<i>β</i> (25-35) on antioxidant enzymes status in 17<i>β</i> estradiol treated aging female rats

Effects of tachykinin neuropeptide NKB and A<i>β</i> (25-35) on antioxidant enzymes status in 17<i>β</i> estradiol treated aging female rats