Administration of bisphenol A to dams during perinatal period modifies molecular and morphological reproductive parameters of the offspring

Accumulation of organotins in seafood leads to reproductive tract abnormalities in female rats

“…In addition, the uterine ER␣ mRNA expression was higher in rodents treated with estrogen varying between 50 g/kg and 4 mg/kg [106,107]. Uterine hypertrophy/hyperplasia and pseudostratification of the LE have been observed with xenobiotic exposure to OTs, phytoestrogen genistein and BPA [51,64,108].…”

“…The characteristics of atretic follicles included pyknotic GCs, disorganized GCs, degenerating oocytes and detachment from the basement membrane. In addition, the thickness of the uterine luminal epithelium (LE), endometrium (ENDO) and myometrium (MYO) were measured, as described by MendozaRodríguez et al [64]. The ovaries and uteri were analyzed by taking 5 regions of each of the 3 sections, resulting in a total of 15 measurements per animal.…”

Mouse Strain Does Not Influence the Overall Effects of Bisphenol A-Induced Toxicity in Adult Antral Follicles1

“…Although some effects such as disrupted uterine implantation and pregnancy maintenance are supported by strong evidence [3][4][5][6][7][8], other effects such as the effects on steroidogenesis are only partially supported by existing data [4,6,[9][10][11][12][13][14][15]. The ambiguity of these studies may be due to the study design, specifically the strain of animal used in the experiments.…”

Histological Effects of Bisphenol- A on Reproductive Organs of Female Wistar Rats.

“…In neonatal exposure to low-dose BPA decreased uterine epithelium proliferation in response to hormone treatments 38 . In two other studies of adult rats, perinatal exposure of BPA caused increase in thickness of uterine epithelia 39,40 . Together, these studies indicate that gestational BPA exposure may be potentially deleterious to uterine morphology in adult females.…”