Administration of amyloid β-peptides in the rat medial septum causes memory deficits: reversal by SR 57746A, a non-peptide neurotrophic compound

Terranova, Jean-Paul; Kan, Jean-Paul; Storme, Jean-Jacques; Perreaut, P.; Fur, G. Le; Soubrié, Philippe

doi:10.1016/0304-3940(96)12859-7

Cited by 35 publications

(20 citation statements)

References 20 publications

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“…Moreover, the discrimination ratio was significantly decreased by the administration of Aβ (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). On the other hand, in mice administered both Aβ (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) and H. erinaceus, exploration time was significantly longer for the novel object than the familiar object, and the discrimination ratio was significantly higher than that of the mice treated with Aβ(25-35) and fed on a control diet (Fig. 2B).…”

Section: Resultsmentioning

confidence: 99%

“…During the choice phase, in the group fed on a control diet, control mice (administered with Aβ(35-25)) spent more time exploring the novel object than the familiar object. In contrast, mice administered with Aβ (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) showed no significant difference in the time spent ex- Fig. 2 Effects of H. erinaceus on Aβ(25-35)-induced memory deficits in the novel-object recognition test.…”

Section: Resultsmentioning

confidence: 99%

“…The powder of H. erinaceus was mixed with a normal powdered diet (MF; Oriental Yeast, Tokyo, Japan), adjusted to contain 5% (w/w) H. erinaceus. The control diet group was given a normal diet containing 5% dextrin for 23 d. Aβ(25-35) peptide and Aβ(35-25) peptides were ed Aβ (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) into the cerebral ventricle resulted in a significant decrease in alternation behavior. However, in mice fed on an H. erinaceus diet, there was no significant difference in alternation behavior between the Aβ(25-35) group and the Aβ(35-25) group (Fig.…”

Section: Administration Of Aβ(25-35) and Experimental Designmentioning

confidence: 99%

“…In addition, one study reported that the 11-amino acid fragment of Aβ, Aβ(25-35) also has potent amnesic effects, and that the Aβ(25-35) region in the Aβ peptide is involved in neurotoxicity accompanied by aggregation (21). Moreover, administration of Aβ(1-40), Aβ(1-42), and Aβ(25-35) peptides has been found to impair learning and memory to the same extent in rodents (25).…”

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confidence: 99%

“…Aβ(35-25), a reversed sequence of Aβ (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35), was used as a control peptide. Learning and memory function of mice was evaluated with behavioral pharmacological methods including the Y-maze test and the novel-object recognition test.…”

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Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice

et al. 2011

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The mushroom Hericium erinaceus has been used as a food and herbal medicine since ancient times in East Asia. It has been reported that H. erinaceus promotes nerve growth factor secretion in vitro and in vivo. Nerve growth factor is involved in maintaining and organizing cholinergic neurons in the central nervous system. These findings suggest that H. erinaceus may be appropriate for the prevention or treatment of dementia. In the present study, we examined the effects of H. erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice. Mice were administered 10 μg of amyloid β(25-35) peptide intracerebroventricularly on days 7 and 14, and fed a diet containing H. erinaceus over a 23-d experimental period. Memory and learning function was examined using behavioral pharmacological methods including the Y-maze test and the novelobject recognition test. The results revealed that H. erinaceus prevented impairments of spatial short-term and visual recognition memory induced by amyloid β(25-35) peptide. This finding indicates that H. erinaceus may be useful in the prevention of cognitive dysfunction.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Administration Of Aβ(25-35) and Experimental Designmentioning

confidence: 99%

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confidence: 99%

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Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice

et al. 2011

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Glutamatergic synaptic depression by synthetic amyloid β‐peptide in the medial septum

Santos-Torres

Fuente

Criado

et al. 2006

J of Neuroscience Research

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The medial septum/diagonal band region, which participates in learning and memory processes via its cholinergic and GABAergic projection to the hippocampus, is one of the structures affected by beta amyloid (betaA) deposition in Alzheimer's disease (AD). The acute effects of betaA (25-35 and 1-40) on action potential generation and glutamatergic synaptic transmission in slices of the medial septal area of the rat brain were studied using current and patch-clamp techniques. The betaA mechanism of action through M1 muscarinic receptors and voltage-dependent calcium channels was also addressed. Excitatory evoked responses decreased (30-60%) in amplitude after betaA (2 microM) perfusion in 70% of recorded cells. However, the firing properties were unaltered at the same concentration. This depression was irreversible in most cases, and was not prevented or reversed by nicotine (5 microM). In addition, the results obtained using a paired-pulse protocol support pre- and postsynaptic actions of the peptide. The betaA effect was blocked by calcicludine (50 nM), a selective antagonist of L-type calcium channels, and also by blocking muscarinic receptors with atropine (5 muM) or pirenzepine (1 microM), a more specific M1-receptor blocker. We show that in the medial septal area this oligomeric peptide acts through calcium channels and muscarinic receptors. As blocking any of these pathways blocks the betaA effects, we propose a joint action through both mechanisms. These results may contribute to a better understanding of the pathophysiology at the onset of AD. This understanding will be required for the development of new therapeutic agents.

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Hippocampal Injections of Amyloid β-Peptide 1-40 Impair Subsequent One-Trial/Day Reward Learning

Malin

Crothers

Lake

et al. 2001

Neurobiology of Learning and Memory

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Administration of amyloid β-peptides in the rat medial septum causes memory deficits: reversal by SR 57746A, a non-peptide neurotrophic compound

Cited by 35 publications

References 20 publications

Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice

Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice

Glutamatergic synaptic depression by synthetic amyloid β‐peptide in the medial septum

Hippocampal Injections of Amyloid β-Peptide 1-40 Impair Subsequent One-Trial/Day Reward Learning

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