ADMET Assays on Tecan's LabCD-ADMET System

Shea, Michelle; Ommert, Shari; Gleich, Lance; Towle, Theresa; Haspel, Howard; Schmid, Noa; Jindal, Hitesh K.; Kellogg, Greg; Carvalho, Bruce; Contarino, Michael; Bansal, Praveen

doi:10.1016/s1535-5535-04-00260-6

Cited by 5 publications

(4 citation statements)

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“…7,8 Gamera, later acquired by Tecan in July 2000, would continue to develop the LabCD mainly for assays related to drug development such as ADMET-absorption, distribution, metabolism, excretion and toxicity. 9 Tecan advanced Gamera's system significantly but discontinued their efforts in 2005.…”

Section: A History Of Centrifugal Microfluidic Technologymentioning

confidence: 99%

Centrifugal microfluidics for biomedical applications

et al. 2010

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The development of a rapid, miniaturized, and efficient on-chip sample preparation for "real" sample analysis remains a major bottleneck for the realization of a lab-on-a-chip approach in point-of-care diagnostics. We developed a fully integrated and automated labon-a-disc using centrifugal microfluidics to provide a "sample-in and answer-out" type of biochemical analysis solution with simple, size-reduced, and cost-efficient instrumentation.1 Here, I present various examples of the fully integrated "lab-on-a-disc" developed for broad applications ranging from medical diagnostics to food, environment, and energy applications (Fig. 1A). Active valves on a spinning discWe pioneered the concept of laser-irradiated ferrowax microvalves (LIFM) with colleagues at Samsung Advanced Institute of Technology (SAIT), which provided a simple and robust tool for obtaining fluidic control on a spinning disc.2 The key achievement of this work was the rapid and wireless actuation of multiple valves by simple laser irradiation on nanoheaters, which are 10-nm-sized ferro-oxide nanoparticles dispersed in paraffin wax (Fig. 1B).2 The response time of both the normally open and normally closed valves was very short, and the actuation of the valves was independent of the sequence of the spin speed, sample type, or material properties of the substrates. More recently, we

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Section: A History Of Centrifugal Microfluidic Technologymentioning

confidence: 99%

Centrifugal microfluidics for biomedical applications

et al. 2010

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“…accounts for its statistical ∆U loss with respect to the total residual volume U loss . The value of ∆U loss (15) should ideally vanish to minimize the band width ∆Ω (7) and improve the related bioanalytical precision, which is the case for merely overflow-driven liquid transfer to the outer DF chamber. Note that an experimental characterization or a refined, computational fluid dynamic (CFD) simulation of the course of valving is required to obtain a more accurate estimate of U loss and ∆U loss .…”

Section: Definition Of Liquid Volumesmentioning

confidence: 99%

Design Optimization of Centrifugal Microfluidic “Lab-on-a-Disc” Systems towards Fluidic Larger-Scale Integration

Ducrée

2021

Applied Sciences

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Enhancing the degree of functional multiplexing while assuring operational reliability and manufacturability at competitive costs are crucial ingredients for enabling comprehensive sample-to-answer automation, e.g., for use in common, decentralized “Point-of-Care” or “Point-of-Use” scenarios. This paper demonstrates a model-based “digital twin” approach, which efficiently supports the algorithmic design optimization of exemplary centrifugo-pneumatic (CP) dissolvable-film (DF) siphon valves toward larger-scale integration (LSI) of well-established “Lab-on-a-Disc” (LoaD) systems. Obviously, the spatial footprint of the valves and their upstream laboratory unit operations (LUOs) have to fit, at a given radial position prescribed by its occurrence in the assay protocol, into the locally accessible disc space. At the same time, the retention rate of a rotationally actuated CP-DF siphon valve and, most challengingly, its band width related to unavoidable tolerances of experimental input parameters need to slot into a defined interval of the practically allowed frequency envelope. To accomplish particular design goals, a set of parametrized metrics is defined, which are to be met within their practical boundaries while (numerically) minimizing the band width in the frequency domain. While each LSI scenario needs to be addressed individually on the basis of the digital twin, a suite of qualitative design rules and instructive showcases structures are presented.

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“…Using (11), we can directly relate the tolerances ΔΩ in critical spin rates Ω (10) to the precision of fundamental experimental parameters for the pipetting or metering Δ , or for vertical and lateral dimensions, e.g., radial positions Δ , cross sections Δ = ( ⋅ Δ ) + ( ⋅ Δ ) and (dead)…”

Section: Reliability Tolerances and Band Widthmentioning

confidence: 99%

Systematic Review of Centrifugal Valving Based on Digital Twin Modelling towards Highly Integrated Lab-on-a-Disc Systems

Ducrée¹

2021

Preprint

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Current, application-driven trends towards larger-scale integration (LSI) of microfluidic systems for comprehensive assay automation and multiplexing pose significant technological and economical challenges to developers. By virtue of their intrinsic capability for powerful sample preparation, centrifugal systems have attracted significant interest in academia and business since the early 1990s. This review models common, rotationally controlled valving schemes at the heart of such “Lab-on-a-Disc” (LoaD) platforms to predict critical spin rates and reliability of flow control mainly based on geometries, location and liquid volumes to be processed, and their experimental tolerances. In absence of larger-scale manufacturing facilities during product development, the method presented here facilitates the provision of efficient simulation tools for virtual prototyping and characterization to greatly expedite design optimization according to key performance metrics. This virtual in silico approach thus significantly accelerates, de-risks and lowers costs along the critical advancement from idea, fluidic testing, bioanalytical validation and scale-up to commercial mass manufacture.

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ADMET Assays on Tecan's LabCD-ADMET System

Cited by 5 publications

References 0 publications

Centrifugal microfluidics for biomedical applications

Centrifugal microfluidics for biomedical applications

Design Optimization of Centrifugal Microfluidic “Lab-on-a-Disc” Systems towards Fluidic Larger-Scale Integration

Systematic Review of Centrifugal Valving Based on Digital Twin Modelling towards Highly Integrated Lab-on-a-Disc Systems

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