ADMA, SDMA and L-Arginine may be Novel Targets in Pharmacotherapy for Complications due to Cardiopulmonary Bypass

Abstract

SummaryBackgroundIn this study, the effects of olmesartan therapy on asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), L-arginine and inducible nitric oxide synthase (iNOS) levels were investigated in patients undergoing cardiopulmonary bypass.MethodsPatients were randomly allocated to two groups, control and olmesartan. Olmesartan was administered 30 mg once a day beginning from preoperative day 5 to postoperative day 28 and on operation day. Blood was drawn from all patients and ADMA, SDMA, L-arginine and iNOS levels were analyzed at six time points (T1: before anesthesia induction, T2: during cardiopulmonary bypass, T3: five min after the cross-clamp was removed, T4: after protamine infusion, T5: on postoperative day 3 and T6: on postoperative day 28).ResultsIn the olmesartan treated group, iNOS levels exhibited significant decreases at T2, T3, T4, T5 and T6 time points compared with control group (p<0.001, p<0.05, p<0.001, p<0.01, p<0.05 respectively). ADMA levels were significantly lower in olmesartan treated group than in control group at T3, T4, T5 and T6 time points (p<0.05, p<0.05, p<0.05, p<0.01 respectively). SDMA levels at T2, T3 and T6 time points were higher in control group than olmesartan group. L-Arginine levels were significantly higher at T2 and T3 time points in olmesartan treated group than control group (p<0.001, p<0.01).ConclusionsIt was concluded that administration of olmesartan reduced plasma ADMA, SDMA, iNOS levels and enhanced L-arginine level in CPB time and it could reduce potential postoperative complications through reducing oxidative stress and inflammatory response in the postoperative period after coronary bypass surgery.

Effects of a herbal formulation, KGC3P, and its individual component, nepetin, on coal fly dust-induced airway inflammation

“…Asymmetrical dimethyl arginine (ADMA) and symmetric dimethyl arginie (SDMA) are involved in the inflammation, endothelial dysfunction and oxidative stress. Basically they are the structural analogues of l -arginine, which competitively regress NO synthase, ultimately leading to decreased basal NO production with the fact that basal NO production is essential for cellular proliferation, vasodilation and migration 18 – 20 . Therefore we had checked the effects of the KG3P treatment on the serum ADMA and SDMA levels.…”

Red Blood Cell Distribution Width Improves Reclassification of Patients Admitted to the Emergency Department with Acute Decompensated Heart Failure

“…Heart failure (HF) is currently diagnosed in over 10% of subjects aged 65 years or older in developed countries (2, 22). The frequent and often life-threatening episodes of ADHF occurring in HF patients need timely therapeutic management and are associated with a remarkably high rate of hospitalization and mortality (2, 23).…”

Development of a novel UHPLC-MS/MS-based platform to quantify amines, amino acids and methylarginines for applications in human disease phenotyping

“…We selected this particular clinical scenario because these patients experience a systemic inflammatory response (SIRS) which in many regards recapitulates early inflammatory 17 events seen in sepsis and that in some cases may even develop into sepsis 18 . Moreover, whilst a full array of amino acids and methylarginines have not been previously measured in samples from cardiopulmonary bypass patients, L-arginine and methylarginine levels have been reported 19 . In this way, measuring plasma samples from the patients provided the opportunity to both test a well-reasoned hypothesis; ‘cardiopulmonary bypass surgery results in a disruption in arginine and related amino acids’ and to generate new hypotheses by using bioinformatics incorporating pathway analysis.…”