Adjuvant therapy with a 980-nm diode laser in root canal retreatment: randomized clinical trial with 1-year follow-up

Pelozo, Laís Lima; Silva-Neto, Reinaldo Dias; Salvador, Sérgio Luiz de Souza; Sousa‐Neto, Manoel Damião; Souza‐Gabriel, Aline Evangelista

doi:10.1007/s10103-022-03659-0

Cited by 8 publications

(4 citation statements)

References 41 publications

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“…For each sample in a pulsing mode, the power output shall be 20 s at 1.5 W and 100 Hz. The diode laser significantly improved healing at 3 to 12 months follow-up ( P < 0.05) and had 45% more healed cases than the placebo ( 26 ).…”

Section: Optimization Of Laser-activated A-pdt Treatmentmentioning

confidence: 93%

Evaluating the potency of laser-activated antimicrobial photodynamic therapy utilizing methylene blue as a treatment approach for chronic periodontitis

Karuppan Perumal,

Rajan Renuka,

Manickam Natarajan

2024

Front. Oral. Health

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Chronic periodontitis is a ubiquitous inflammatory disease in dental healthcare that is challenging to treat due to its impact on bone and tooth loss. Conventional mechanical debridement has been challenging in eliminating complex subgingival biofilms. Hence, adjunctive approaches like low-level laser antimicrobial photodynamic therapy (A-PDT) utilising methylene blue (MB) have been emerging approaches in recent times. This review evaluates the latest research on the use of MB-mediated A-PDT to decrease microbial count and enhance clinical results in chronic periodontitis. Studies have shown the interaction between laser light and MB generates a phototoxic effect thereby, eliminating pathogenic bacteria within periodontal pockets. Moreover, numerous clinical trials have shown that A-PDT using MB can reduce probing depths, improve clinical attachment levels, and decrease bleeding during probing in comparison to traditional treatment approaches. Notably, A-PDT shows superior antibiotic resistance compared to conventional antibiotic treatments. In conclusion, the A-PDT using MB shows promise as an adjunctive treatment for chronic periodontitis. Additional research is required to standardize treatment protocols and assess long-term outcomes of A-PDT with MB in the treatment of periodontitis.

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Section: Optimization Of Laser-activated A-pdt Treatmentmentioning

confidence: 93%

Evaluating the potency of laser-activated antimicrobial photodynamic therapy utilizing methylene blue as a treatment approach for chronic periodontitis

Karuppan Perumal,

Rajan Renuka,

Manickam Natarajan

2024

Front. Oral. Health

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“…Polymicrobial infection and its products in the pulp tissue are responsible for periarticular damage and preoperative pain [ 1 - 3 ]. The persistence of pathogenic bacteria and the complexity of root canal anatomy directly influence the treatment outcomes [ 2 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Persistent infections are usually characterized by the presence of primarily resistant gram-positive facultative anaerobes, including Streptococcus mutans , Staphylococcus aureus , and Enterococcus faecalis , and some gram-negative strains such as Escherichia coli and Candida albicans fungus [ 2 , 3 , 5 ]. The success of root canal treatment depends on chemo-mechanical debridement, using solutions and endodontic files, and efficient tridimensional sealing of the canal system [ 4 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Characterization, Antimicrobial Activity, and Antioxidant Efficacy of a Pomegranate Peel Solution Against Persistent Root Canal Pathogens

Gallas¹,

Pelozo²,

Oliveira³

et al. 2023

Cureus

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Background: The limitations of dental irrigation solutions reinforce the need to explore novel bioactive compounds that are safer and biodegradable. This study aimed to prepare a 10% pomegranate peel solution ( Punica granatum extract - PGE) and evaluate its antimicrobial and antioxidant effects for root canal treatment. Methods: Lyophilized extracts (1g/10 mL) from pomegranate peels were prepared, and the punicalagin content was assessed by ultra-performance liquid chromatography using pure punicalagin (standard). The antimicrobial activity was tested against common persistent root canal pathogens by the agar diffusion method, minimum inhibitory concentration (MIC), and minimum bactericidal/fungicide concentration (MCB/MFC). The antioxidant activity (%AA) was assessed by the DPPH radical scavenging method. Data were analyzed by ANOVA and Tukey's test (α = 0.05). Results: The total phenolic content of the PGEextract was 6.55 µg/mL. Differences were found among the inhibition zone of PGE (23.32 ± 3.65), 1% NaOCl (30.76 ± 4.73), and 50% ethanol (without inhibition) (p < 0.05). The MIC values of PGE ranged between 6.25 and 75 mg/ml, and PGE was effective against the tested pathogens. PGE had antioxidant potential (IC50 = 3.52 µg/mL); however, the mean values were inferior to that of the quercetin (positive control) (IC50 = 0.95 µg/mL). The DPPH scavenging effect (%AA) of PGE (70.98 ± 2.3) had no difference from the positive control (72.94 ± 2.1) (p = 0.253). Conclusion: The PGE extract was successfully biosynthesized and exhibited antimicrobial and antioxidant activity, suggesting its potential use as an adjuvant therapy during root canal treatment.

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Bioburden assessment of necrotic teeth disinfected with sodium hypochlorite, diode laser, and photodynamic therapy using flow cytometry—a randomized double-blinded clinical trial

Rai,

Sundaramoorthy,

Mahalaxmi

et al. 2023

Lasers Med Sci

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Adjuvant therapy with a 980-nm diode laser in root canal retreatment: randomized clinical trial with 1-year follow-up

Cited by 8 publications

References 41 publications

Evaluating the potency of laser-activated antimicrobial photodynamic therapy utilizing methylene blue as a treatment approach for chronic periodontitis

Evaluating the potency of laser-activated antimicrobial photodynamic therapy utilizing methylene blue as a treatment approach for chronic periodontitis

Characterization, Antimicrobial Activity, and Antioxidant Efficacy of a Pomegranate Peel Solution Against Persistent Root Canal Pathogens

Bioburden assessment of necrotic teeth disinfected with sodium hypochlorite, diode laser, and photodynamic therapy using flow cytometry—a randomized double-blinded clinical trial

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