Adjuvant Therapy for Revision Rhinoplasty of Contracted Nose Using Polydeoxyribonucleotide and Invasive Bipolar Radiofrequency

Ahn, Tae Hwan; Cho, Sung Bin

doi:10.1097/gox.0000000000001645

Cited by 11 publications

(10 citation statements)

References 12 publications

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“…[12][13][14] Previously, our study group reported that nasal skin in patients with a severely contracted nose was markedly improved by performing repetitive PDRN injections and invasive pulsed radiofrequency treatments before and after revision rhinoseptoplasty. 2 In this study, we suggested that the intralesional injection of PDRN could enhance the wound repair and remodeling of microscopic treatment zones generated by delivering MLA-type, nanosecond-domain Nd:YAG laser pulses to scars from costal harvest surgery.…”

Section: Discussionmentioning

confidence: 92%

“…1 However, because patients with a severely contracted nose typically present with insufficient septal cartilage, costal cartilage harvest surgery is also required for revision septorhinoplasty. [1][2][3] Therein, rib cartilage is usually harvested from the eighth or ninth rib and then symmetrically sculpted for a columellar strut graft depending on the size of the tip projection. 3 However, postoperative scarring on the anterolateral rib cage commonly requires additional scar treatments.…”

Section: Introductionmentioning

confidence: 99%

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Polydeoxyribonucleotide and Microlens Array-type, Nanosecond-domain Neodymium:Yttrium-aluminum-garnet Laser Treatment for Scars from Costal Cartilage Harvest Surgery: Case Series of 9 Patients

Ahn

Kim

Cheon³

et al. 2021

Medical Lasers

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Background and ObjectivesSurgery for harvesting costal cartilage is often required for revision septorhinoplasty due to a lack of septal cartilage in patients with a severely contracted nose, and postoperative scarring on the anterolateral rib cage commonly requires additional treatment. This study aimed to evaluate the therapeutic efficacy and safety of combined polydeoxyribonucleotide (PDRN) and microlens array (MLA)-type nanoseconddomain neodymium (Nd):yttrium-aluminum-garnet (YAG) laser treatment for postoperative scars after costal cartilage harvest surgery. Materials and MethodsNine Korean patients with scars after costal cartilage harvest surgery treated with PDRN injections and MLA-type Nd:YAG laser treatments were retrospectively reviewed. ResultsMost of the scar lesions exhibited clinical improvement at 2 weeks after PDRN and MLA-type nanosecond-domain laser treatments, and the lesions further improved after adding more treatment sessions. The median Vancouver Scar Scale (VSS) score decreased from 6 (interquartile range [IQR]: 6-7) before combined intralesional PDRN injection and MLA-type, nanosecond-domain Nd:YAG laser treatments to 3 (IQR: 2-4) thereafter. Patient satisfaction after the combination treatments was rated as satisfactory. None of our patients reported major adverse events. ConclusionThis case series study demonstrated that combined PDRN and MLAtype, nanosecond-domain Nd:YAG laser treatments are effective and safe for treating scars from costal cartilage harvest surgery.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Polydeoxyribonucleotide and Microlens Array-type, Nanosecond-domain Neodymium:Yttrium-aluminum-garnet Laser Treatment for Scars from Costal Cartilage Harvest Surgery: Case Series of 9 Patients

Ahn

Kim

Cheon³

et al. 2021

Medical Lasers

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“…A 2017 study investigated the capacity of Ok-PDRN to inhibit diabetic foot ulcers [ 56 ]. In this study, intramuscular Ok-PDRN administration was conducted after initial surgical debridement of the necrotic tissue on type 2 diabetes patients exhibiting diabetic foot ulcers.…”

Section: Resultsmentioning

confidence: 99%

Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering

Kim

Heo

et al. 2021

Marine Drugs

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Polydeoxyribonucleotides (PDRNs) are a family of DNA-derived drugs with a molecular weight ranging from 50 to 1500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many pre-clinical and clinical studies have demonstrated the wound healing and anti-inflammatory properties of PDRN, which are mediated by the activation of adenosine A2A receptor and salvage pathways, in addition to promoting osteoblast activity, collagen synthesis, and angiogenesis. In fact, PDRN is already marketed due to its therapeutic properties against various wound healing- and inflammation-related diseases. Therefore, this review assessed the most recent trends in marine organism-derived PDRN using the Google Scholar search engine. Further, we summarized the current applications and pharmacological properties of PDRN to serve as a reference for the development of novel PDRN-based technologies.

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“…[7][8][9][10] Revision rhinoseptoplasty is sometimes required in patients with a severely contracted nose resulting from excessive inflammatory reactions and fibrosis along nasal implants. 7,8 A severely contracted nose is a serious complication that often accompanies insufficient septal cartilage and disorganized, thick fibrotic skin, which complicates the performance of a rhinoseptoplasty. 7,8 To achieve maximal surgical outcomes and minimal downtime, many surgeons have adopted more minimally invasive procedures and stressed proper pre-and postoperative management.…”

mentioning

confidence: 99%

“…7,8 A severely contracted nose is a serious complication that often accompanies insufficient septal cartilage and disorganized, thick fibrotic skin, which complicates the performance of a rhinoseptoplasty. 7,8 To achieve maximal surgical outcomes and minimal downtime, many surgeons have adopted more minimally invasive procedures and stressed proper pre-and postoperative management. 9,10 Perilesional edema and ecchymosis after rhinoseptoplasty and revision rhinoseptoplasty are distressing complications to both surgeons and patients.…”

mentioning

confidence: 99%

Use of quantum molecular resonance energy for managing postrhinoseptoplasty perilesional edema and ecchymosis

Ahn

Kim²,

Kim³

et al. 2021

J of Cosmetic Dermatology

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Background Quantum molecular resonance (QMR) technology employs nonionizing high‐frequency waves ranging from 4 to 64 MHz to generate low‐intensity quanta of energy that interacts with cellular components. Aims To evaluate the efficacy and safety of QMR treatment on postoperative perilesional edema and ecchymosis in patients with rhinoseptoplasty or revision rhinoseptoplasty. Patients/Methods In total, 30 patients were treated with QMR stimulation therapy (QMR group) once daily for 5 days, while another 30 patients were treated with conventional icepack application (control group). The duration of perilesional edema and ecchymosis were comparatively evaluated according to anatomic regions. Results In both groups, the longest duration of postoperative edema and ecchymosis was found on the left anterior cheek, followed by the right anterior cheek, left lower eyelid, right lower eyelid, and right and left upper eyelids. The mean duration of overall postoperative perilesional edema was significantly shorter in the QMR group (2.0 ± 0.8 days) than the control group (4.6 ± 2.0 days); the mean duration of overall ecchymosis was also markedly shorter in the QMR group (2.9 ± 1.5 days) than control group (7.5 ± 2.9 days). Patient satisfaction after postoperative QMR treatment was rated as 2.2 ± 0.8, whereas patient satisfaction in control group was rated as 1.6 ± 0.9. Conclusion Our clinical study demonstrated that postrhinoseptoplasty QMR treatment effectively reduces the duration of postoperative perilesional edema and ecchymosis without remarkable side effects. We suggest that QMR treatment can be considered as an alternative option for noninvasively managing postrhinoseptoplasty perilesional edema and ecchymosis.

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Adjuvant Therapy for Revision Rhinoplasty of Contracted Nose Using Polydeoxyribonucleotide and Invasive Bipolar Radiofrequency

Abstract: Supplemental Digital Content is available in the text.

Cited by 11 publications

References 12 publications

Polydeoxyribonucleotide and Microlens Array-type, Nanosecond-domain Neodymium:Yttrium-aluminum-garnet Laser Treatment for Scars from Costal Cartilage Harvest Surgery: Case Series of 9 Patients

Polydeoxyribonucleotide and Microlens Array-type, Nanosecond-domain Neodymium:Yttrium-aluminum-garnet Laser Treatment for Scars from Costal Cartilage Harvest Surgery: Case Series of 9 Patients

Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering

Use of quantum molecular resonance energy for managing postrhinoseptoplasty perilesional edema and ecchymosis

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