Polydeoxyribonucleotide and Microlens Array-type, Nanosecond-domain Neodymium:Yttrium-aluminum-garnet Laser Treatment for Scars from Costal Cartilage Harvest Surgery: Case Series of 9 Patients

Abstract

Background and ObjectivesSurgery for harvesting costal cartilage is often required for revision septorhinoplasty due to a lack of septal cartilage in patients with a severely contracted nose, and postoperative scarring on the anterolateral rib cage commonly requires additional treatment. This study aimed to evaluate the therapeutic efficacy and safety of combined polydeoxyribonucleotide (PDRN) and microlens array (MLA)-type nanoseconddomain neodymium (Nd):yttrium-aluminum-garnet (YAG) laser treatment for postoperative scars after costal cartilage harvest surgery. Materials and MethodsNine Korean patients with scars after costal cartilage harvest surgery treated with PDRN injections and MLA-type Nd:YAG laser treatments were retrospectively reviewed. ResultsMost of the scar lesions exhibited clinical improvement at 2 weeks after PDRN and MLA-type nanosecond-domain laser treatments, and the lesions further improved after adding more treatment sessions. The median Vancouver Scar Scale (VSS) score decreased from 6 (interquartile range [IQR]: 6-7) before combined intralesional PDRN injection and MLA-type, nanosecond-domain Nd:YAG laser treatments to 3 (IQR: 2-4) thereafter. Patient satisfaction after the combination treatments was rated as satisfactory. None of our patients reported major adverse events. ConclusionThis case series study demonstrated that combined PDRN and MLAtype, nanosecond-domain Nd:YAG laser treatments are effective and safe for treating scars from costal cartilage harvest surgery.

Combination treatments employing CO2 fractional lasers with polydeoxyribonucleotide injections for chronic atrophic scar in Republic of Korea: a case report

“…Another study by Ahn et al [6] reported the effects of PDRN and microlens arrayed type nanosecond-domain Nd:YAG laser combination therapy on postoperative scarring after costal cartilage harvest surgery, further supporting the wound healing-promoting results of PDRN. Ablative CO2 fractional lasers have been used and studied for many years to treat various dermatological conditions, including different types of scars.…”

Efficacy of Polydeoxyribonucleotide in Promoting the Healing of Diabetic Wounds in a Murine Model of Streptozotocin-Induced Diabetes: A Pilot Experiment

“…Second, we failed to assess the efficacy of an intra-lesional injection of PDRN in promoting WH. According to a review of the literature, an intra-lesional injection of PDRN has been assessed in the context of plastic and aesthetic surgery [63,64]. Further studies are therefore warranted to assess its efficacy in promoting the healing of diabetic wounds in a murine model of STZ-induced diabetes.…”