Adjuvant-Induced Arthritis in Rats I. Temporal Relationship of Physiological, Biochemical, and Hematological Parameters

Walz, D. T.; DiMartino, Michael J.; Kuch, J; Zuccarello, William A.

doi:10.3181/00379727-136-35392

Cited by 79 publications

(58 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The primary swelling of adjuvant-injected hind paws is observed between day 1 and day 4 after mycobacterial adjuvant injection, and the secondary swelling, which is characterized by inflammation of both the paws and legs, especially the adjuvant uninjected hind paws, occurrs with a delay of approximately 10 days after adjuvant injection (11). Therapeutic treatment with FR188582 showed an anti-inflammatory effect for the secondary swelling in adjuvant arthritic rat paws in a dose-dependent manner similarly to indomethacin.…”

Section: Discussionmentioning

confidence: 91%

“…Adjuvant arthritis was induced in female Lewis rats by intradermal injection into the plantar suface of the right hind paw of 0.5 mg of a suspension of heat-killed and dried Mycobacterium tuberculosis H37 RA (Difco, Detroit, MI, USA) in 0.05 ml of liquid Paraffin (day 0) (10,11). The drugs, suspended and diluted on 0.5% methylcellulose, were given orally once a day therapeutically from day 15 to day 24 after adjuvant injection.…”

Section: Induction Of Adjuvant Arthritismentioning

confidence: 99%

See 1 more Smart Citation

The Anti-inflammatory Effect of FR188582, a Highly Selective Inhibitor of Cyclooxygenase-2, With an Ulcerogenic Sparing Effect in Rats

Ochi

Yamane-Sugiyama

Ohkubo

et al. 2001

Japanese Journal of Pharmacology

View full text Add to dashboard Cite

ABSTRACT-The anti-inflammatory and ulcerogenic effects of FR188582, 3-chloro-5-[4-(methylsulfonyl) phenyl]-1-phenyl-1H-pyrazole, were investigated. In a recombinant human cyclooxygenase (COX) enzyme activity, FR188582 inhibited COX-2 with an IC50 value of 0.017 mM, and the inhibition of prostaglandin (PG) E2 formation by FR188582 was over 6000 times more selective for COX-2 than COX-1. Oral administration of FR188582 dose-dependently inhibited adjuvant arthritis. This effect was threefold more potent than that of indomethacin. FR188582 and indomethacin dose-dependently suppressed the formation of immunoreactive PGE 2, but not immunoreactive leukotriene (LT) B4, in arthritic paw. Unlike indomethacin, FR188582 did not induce visible gastric lesions in rats at doses up to 32 mg/kg, p.o. Furthermore, FR188582 did not inhibit the level of immunoreactive PGE2 and immunoreactive 6-keto PGF1= in rat gastric mucosa. These results suggest that FR188582, a highly selective COX-2 inhibitor, has a potent anti-inflammatory effect mediated by inhibition of PGE2 in inflamed tissues. The safety profile of FR188582 appears to be improved over the safety profile of indomethacin.

show abstract

Section: Discussionmentioning

confidence: 91%

Section: Induction Of Adjuvant Arthritismentioning

confidence: 99%

The Anti-inflammatory Effect of FR188582, a Highly Selective Inhibitor of Cyclooxygenase-2, With an Ulcerogenic Sparing Effect in Rats

Ochi

Yamane-Sugiyama

Ohkubo

et al. 2001

Japanese Journal of Pharmacology

View full text Add to dashboard Cite

show abstract

“…The first 4 days postadjuvant comprise the stage of sensitization and the sixth to tenth days represent the phase of cellular production in AID (20). Since AID can be transferred between highly inbred rats 8 to 10 days after the administration of adjuvant, cellular sensitization and proliferation must be relatively complete at that time.…”

Section: Discussionmentioning

confidence: 99%

The effect of a cobra venom factor on complement and adjuvant‐induced disease in rats

Kourounakis

Nelson

Kupusta

1973

Arthritis & Rheumatism

View full text Add to dashboard Cite

The parenteral administration of mycobacterial adjuvant into rats induces an arthropathy which is generally believed to be due to cellular hypersensitivity. The role of complement in this phenomenon has not been defined. The levels of individual complement components were measured in sera of normal and adjuvant-treated rats. The effect of decomplementation with cobra venom factor (CVF) was studied in adjuvant-induced disease (AID). It was found that C9 is elevated in AID; and that CVF temporarily depletes C3 and delays the onset of arthritis. This suggests that certain complement components may play a role in this form of hypersensitivity.

show abstract

“…Detection of serum antibody: Serum anti body to LPS and TNP was determined as hemagglutination (HA) titers of both 7S and 19S antibodies by the method of Walz et al (15). LPS or TNP-coated SRBC were used for the detection of antibody to LPS or TN P. …”

Section: Methodsmentioning

confidence: 99%

Traxanox augments immune response to lipopolysaccharide in inbred mice: Role of macrophages.

Goto¹,

Hisadome²,

Terasawa³

et al. 1983

Jpn.J.Pharmacol

View full text Add to dashboard Cite

show abstract

Adjuvant-Induced Arthritis in Rats I. Temporal Relationship of Physiological, Biochemical, and Hematological Parameters

Cited by 79 publications

References 0 publications

The Anti-inflammatory Effect of FR188582, a Highly Selective Inhibitor of Cyclooxygenase-2, With an Ulcerogenic Sparing Effect in Rats

The Anti-inflammatory Effect of FR188582, a Highly Selective Inhibitor of Cyclooxygenase-2, With an Ulcerogenic Sparing Effect in Rats

The effect of a cobra venom factor on complement and adjuvant‐induced disease in rats

Traxanox augments immune response to lipopolysaccharide in inbred mice: Role of macrophages.

Contact Info

Product

Resources

About