Adjuvant activity of diesel-exhaust particulates for the production of IgE antibody in mice

Muranaka, M; Suzuki, Shuji; Koizumi, Kazuhiro; Takafuji, Shigeru; Miyamoto, Tomofumi; Ikemori, R; Tokiwa, Hiroshi

doi:10.1016/0091-6749(86)90355-6

Cited by 348 publications

(178 citation statements)

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“…These acute exacerbations are characterized by increased symptom score as well as the requirement for more frequent medication and hospitalization [39,40]. In addition to these acute effects, which are likely caused by an exacerbation of already existing airway inflammation and airway hyperreactivity, there is increasing evidence that particulate pollutants act as an adjuvant for allergic sensitization to common environmental allergens [25,[42][43][44][45][46]. This raises the possibility that long-term PM exposures may lead to increased prevalence of asthma and allergic diseases.…”

Section: The Impact Of Particulate Pollutants On Asthmamentioning

confidence: 99%

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The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles

Xia

Nel

2008

Free Radical Biology and Medicine

810

529

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Ambient particulate matter (PM) is an environmental factor that has been associated with increased respiratory morbidity and mortality. The major effect of ambient PM on the pulmonary system is the exacerbation of inflammation, especially in susceptible people. One of the mechanisms by which ambient PM exerts its proinflammatory effects is the generation of oxidative stress by its chemical compounds and metals. Cellular responses to PM-induced oxidative stress include activation of antioxidant defense, inflammation, and toxicity. The pro-inflammatory effect of PM in the lung is characterized by increased cytokine/chemokine production and adhesion molecule expression. Moreover, there is evidence that ambient PM can act as an adjuvant for allergic sensitization, which raises the possibility that long-term PM exposure may lead to increased prevalence of asthma. In addition to ambient PM, rapid expansion of nanotechnology has introduced the potential that engineered NP may also become airborne and may contribute to pulmonary diseases by novel mechanisms that could include oxidant injury. Currently, little is known about the potential adverse health effect of these particles. In this communication, the mechanisms by which particulate pollutants, including ambient PM and engineered NP, exert their adverse effects through the generation of oxidative stress and the impacts of oxidant injury in the respiratory tract will be reviewed. The importance of cellular antioxidant and detoxification pathways in protecting against particle-induced lung damage will also be discussed.

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Section: The Impact Of Particulate Pollutants On Asthmamentioning

confidence: 99%

“…The adjuvant effects of ambient PM and DEP have been demonstrated in a number of human and animal studies [42][43][44][45][46]. Combined DEP and ragweed nasal challenge significantly enhances ragweed-specific IgE and IL-4 production in humans [44].…”

Section: The Impact Of Particulate Pollutants On Asthmamentioning

confidence: 99%

The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles

Xia

Nel

2008

Free Radical Biology and Medicine

810

529

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“…A number of studies on the adverse effects of diesel exhaust particles (DEP) on human health, including lung cancer (McClellan 1987;Ichinose et al 1997), allergic rhinitis (Muranaka 1986;Takafuji et al 1987), bronchial asthma-like disease (Sagai et al 1996;Miyabara et al 1998), and disruption of endocrine function, have been reported (Yoshida et al 1999;Watanabe & Oonuki 1999;Tsukue et al 2001Tsukue et al , 2002. While these studies have furnished epidemiologically important results, they have been done without knowledge of the bioactive entities in DEP, making it difficult to estimate the effect of individual components on human health.…”

Section: Introductionmentioning

confidence: 99%

Isolation and identification of new vasodilative substances in diesel exhaust particles

Seki

Noya

Mikami

et al. 2009

Environ Sci Pollut Res

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Goal, Scope, and Background We recently developed a new isolation method for diesel exhaust particles (DEP), involving successive extraction with H 2 O, sodium bicarbonate, and sodium hydroxide, in which the sodium hydroxide extract was found to consist of phenolic components. Analysis of the extract revealed that vasodilative active nitrophenols are in DEP in significantly higher concentration than those estimated by an earlier method involving a combination of solvent extraction and repeated chromatography. These findings indicated that our new procedure offers a simple, efficient and reliable method for the isolation and identification of bioactive substances in DEP. This encouraged us to extend our work to investigating new vasodilatory substances in the sodium bicarbonate extract. Materials and Methods DEP were collected from the exhaust of a 4JB1-type engine (ISUZU Automobile Co., Tokyo, Japan). GC-MS analysis was performed with a GCMS-QP2010 instrument (Shimadzu, Kyoto, Japan).Results DEP dissolved in 1-butanol was successively extracted with water, sodium bicarbonate, and then aqueous sodium hydroxide. The sodium bicarbonate extract was neutralized and the resulting mixture of acidic components was subjected to reverse-phase (RP) column chromatography followed by RP-HPLC with fractions assayed for vasodilative activity. This led to the identification of telephthalic acid, p-hydroxybenzoic acid, isophthalic acid, phthalic acid, 3-hydroxy-4-nitrobenzoic acid, 4-hydroxy-3-nitrophenol, and 1,4,5-naphthalene tricarboxylic acid as components of DEP. DiscussionThe sodium bicarbonate extract was rich in the acidic components. Repeated reverse-phase chromatography resulted in the successful isolation of several acidic substances including the new vasodilative materials, 4-hydroxy-3-nitrobenzoic acid and 3-hydroxy-4-nitrobenzoic acid. Seidel et al. 2006). A number of studies on the adverse effects of diesel exhaust particles (DEP) on human health, including lung cancer (McClellan 1987;Ichinose et al. 1997), allergic rhinitis (Muranaka 1986;Takafuji et al. 1987), bronchial asthma-like disease (Sagai et al. 1996;Miyabara et al. 1998), and disruption of endocrine function, have been reported (Yoshida et al. 1999;Watanabe & Oonuki 1999;Tsukue et al. 2001Tsukue et al. , 2002. While these studies have furnished epidemiologically important results, they have been done without knowledge of the bioactive entities in DEP, making it difficult to estimate the effect of individual components on human health. In our earlier studies on the isolation and identification of bioactive compounds contained in DEP, we have isolated aromatic substances including nitrophenols (Mori et al. 2003a;Taneda et al. 2004a) that showed strong vasodilatory activity by a method involving successive solvent extractions, followed by repeated column chromatography. This multi-step isolation procedure, however, resulted in poor fractionation with impaired accuracy and reproducibility. Therefore, it was crucial to develop a more efficient and ...

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“…This effect facilitates the increase in bronchial responsiveness to inhaled pollen allergens in predisposed subjects (240,241). Moreover, some components of air pollution seem to have an adjuvant immunologic effect on IgE synthesis in atopic subjects (239,242,243).…”

Section: Avoidance Of Environmental Pollutantsmentioning

confidence: 99%

Avoidance of allergens and air pollutants in respiratory allergy

Liccardi¹,

Čustović²,

Cazzola³

et al. 2001

Allergy

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Adjuvant activity of diesel-exhaust particulates for the production of IgE antibody in mice

Cited by 348 publications

References 10 publications

The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles

The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles

Isolation and identification of new vasodilative substances in diesel exhaust particles

Avoidance of allergens and air pollutants in respiratory allergy

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