Adjusted leptin level (ALL) is a predictor for hyperemesis gravidarum

Demır, Berfu; Erel, C. Tamer; Haberal, Alı; Öztürk, Nilgün Turhan; Güler, Dilek; Koçak, Müberra

doi:10.1016/j.ejogrb.2004.11.012

Cited by 25 publications

(23 citation statements)

References 19 publications

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“…We did not find a relationship between NV and leptin in this study, which is consistent with the work of Ozturk Arslan et al (2003) and Unsel et al (2004) but contrasts with the findings of other studies (Aka et al, 2006;Demir et al, 2006). A possible explanation for this apparent discrepancy is, again, the severity of NV.…”

Section: Discussioncontrasting

confidence: 65%

Relationships Between Leptin, hCG, Cortisol, and Psychosocial Stress and Nausea and Vomiting Throughout Pregnancy

Kuo

Yang

Wang

et al. 2010

Biological Research For Nursing

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The purposes of this prospective, longitudinal study were to examine the relationships between leptin, human chorionic gonadotropin (hCG), cortisol, and psychosocial stress and nausea and vomiting (NV) in women with mild-to-moderate NV throughout pregnancy. Participants comprised 91 pregnant women recruited from prenatal clinics in southern Taiwan. Data analysis using one-way analysis of variance (ANOVA) indicated that leptin, hCG, cortisol levels, and Index of Nausea, Vomiting, and Retching (INVR) scores, but not stress (measured with the Visual Analog Scale, VAS) scores, were significantly different among the three trimesters. The average INVR score and hCG level decreased from the first to third trimesters (p< .0001 for both). The average leptin and cortisol levels increased from the first to third trimesters (p = .001 and p < .0001, respectively). Analysis using mixed models indicated that the INVR scores decreased significantly in a progressive manner through the stages of pregnancy and were significantly lower in the second and third trimesters. Findings reveal that stress/VAS and hCG may both be significantly and independently associated with INVR scores. Future research should examine psychosocial reactions in addition to exploring other biochemical markers related to NV and stress.

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Section: Discussioncontrasting

confidence: 65%

Relationships Between Leptin, hCG, Cortisol, and Psychosocial Stress and Nausea and Vomiting Throughout Pregnancy

Kuo

Yang

Wang

et al. 2010

Biological Research For Nursing

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“…There was no difference observed in haematocrit and urine-specific gravity, as dehydration indicators, between two groups, suggesting that dehydration in the women with hyperemesis gravidarum is not a cause of these differences. Demir et al 8 used parametrical methods for the statistical evaluation of the adjusted leptin level and found it significantly high. In our study, we detected no statistically significant difference in the adjusted leptin level between the groups and attributed this to the use of the non-parametric methods with small number of cases in our study.…”

Section: Discussionmentioning

confidence: 99%

“…The sensitivity of the assay was 0.12 ng/mL. Similar to the study performed by Demir et al, 8 the adjusted leptin levels were calculated by dividing the maternal leptin levels by the gestational week.…”

Section: Methodsmentioning

confidence: 99%

Leptin and leptin receptor levels in pregnant women with hyperemesis gravidarum

Aka

Atalay

Sayharman

et al. 2006

Aust NZ J Obst Gynaeco

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“…Increased serum leptin levels during pregnancy, possibly the result of increased total fat mass and the placenta production have been found to be significantly higher in patients with HG when compared to healthy pregnant controls [50, 51]. Leptin may contribute to HG by increasing hCG secretion by the paracrine action of the placenta or by decreasing appetite and promoting more severe nausea and vomiting.…”

Section: Pathogenesismentioning

confidence: 99%