Leptin and leptin receptor levels in pregnant women with hyperemesis gravidarum

Aka, Nurettin; Atalay, Sacide; Sayharman, Sema Etiz; Kiliç, Düzgün; Köse, Gültekin; Küçüközkan, Tuncay

doi:10.1111/j.1479-828x.2006.00590.x

Cited by 40 publications

(21 citation statements)

References 19 publications

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“…51 Lower levels of leptin were found in 1 study of 20 patients with HG compared with 20 controls as were higher levels of nesfatin-1, another hormone thought to regulate appetite and weight. 52 Of note, the leptin level results in this study differ from what has previously been reported in the literature 53 ; thus, further studies are needed to determine the role of hunger hormones in HG and whether they can serve as a marker for disease severity.…”

Section: Psychologic Factorscontrasting

confidence: 84%

Hyperemesis Gravidarum

2018

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Nausea and vomiting of pregnancy affect the majority of pregnancies, while the most severe version, hyperemesis gravidarum (HG), affects a much smaller subset of women. Despite the prevalence of nausea and vomiting of pregnancy and the severe consequences of HG, the pathophysiology of these conditions is not fully understood. Currently, it is thought that a combination of hormonal factors accounts for their development. Multiple treatments have been described for nausea and vomiting of pregnancy and HG with varying levels of success. In this paper we describe the epidemiology of nausea and vomiting of pregnancy and HG, the recommended workup, their proposed etiologic factors, treatments, and their potential impact on mother and baby.

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Section: Psychologic Factorscontrasting

confidence: 84%

Hyperemesis Gravidarum

2018

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“…We did not find a relationship between NV and leptin in this study, which is consistent with the work of Ozturk Arslan et al (2003) and Unsel et al (2004) but contrasts with the findings of other studies (Aka et al, 2006;Demir et al, 2006). A possible explanation for this apparent discrepancy is, again, the severity of NV.…”

Section: Discussioncontrasting

confidence: 64%

Relationships Between Leptin, hCG, Cortisol, and Psychosocial Stress and Nausea and Vomiting Throughout Pregnancy

Kuo

Yang

Wang

et al. 2010

Biological Research For Nursing

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The purposes of this prospective, longitudinal study were to examine the relationships between leptin, human chorionic gonadotropin (hCG), cortisol, and psychosocial stress and nausea and vomiting (NV) in women with mild-to-moderate NV throughout pregnancy. Participants comprised 91 pregnant women recruited from prenatal clinics in southern Taiwan. Data analysis using one-way analysis of variance (ANOVA) indicated that leptin, hCG, cortisol levels, and Index of Nausea, Vomiting, and Retching (INVR) scores, but not stress (measured with the Visual Analog Scale, VAS) scores, were significantly different among the three trimesters. The average INVR score and hCG level decreased from the first to third trimesters (p< .0001 for both). The average leptin and cortisol levels increased from the first to third trimesters (p = .001 and p < .0001, respectively). Analysis using mixed models indicated that the INVR scores decreased significantly in a progressive manner through the stages of pregnancy and were significantly lower in the second and third trimesters. Findings reveal that stress/VAS and hCG may both be significantly and independently associated with INVR scores. Future research should examine psychosocial reactions in addition to exploring other biochemical markers related to NV and stress.

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“…We also postulated that some big molecular substances or secretion resulted from unclosed neural tube, particularly in individuals with anencephaly, may play a role in the occurrence of severe NVP. Many researchers have concluded that pregnant women with very severe NVP (i.e., hyperemesis gravidarum) had higher circulating leptin levels than pregnant women without severe NVP (Aka et al, 2006;Chou et al, 2011;Demir et al, 2006). Busbug demonstrated increased leptin levels in maternal serum and amniotic fluid in pregnant women who had fetuses with NTDs compared with a control group (Busbug et al, 2003).…”

Section: Discussionmentioning

confidence: 99%