Adjustable and ultrafast light-cured hyaluronic acid hydrogel: promoting biocompatibility and cell growth

Zhang, Qianmin; Wei, Xiaojuan; Ji, Yongli; Li, Yin; Dong, Zaizai; Chen, Feng; Zhong, Ming; Shen, Jian; Liu, Zhenjie; Chang, Lingqian

doi:10.1039/c9tb02796c

Cited by 26 publications

(19 citation statements)

References 31 publications

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“…In the current work, a soft, elastic, biocompatible, and biodegradable copolymer of PCL-PU , is synthesized and used for the fabrication of soft shape-morphing structures that allow uniaxial cell alignment. The second component of the shape-morphing structure is biocompatible and biodegradable hyaluronic acid, which is one of the components of ECM. , Therefore, it is expected to be more suitable than alginate. − Moreover, sheets of cross-linked hyaluronic acid are able to undergo shape transformation and form tubular structures. Shape transformation occurs because of the formation of a vertical gradient of cross-linking density obtained during cross-linking of the polymer and it is triggered by its immersion in water .…”

Section: Introductionmentioning

confidence: 99%

Shape-Morphing Fibrous Hydrogel/Elastomer Bilayers Fabricated by a Combination of 3D Printing and Melt Electrowriting for Muscle Tissue Regeneration

Uribe-Gomez

Posada-Murcia

Shukla

et al. 2021

ACS Appl. Bio Mater.

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This paper reports an approach for the fabrication of shape-changing bilayered scaffolds, which allow the growth of aligned skeletal muscle cells, using a combination of 3D printing of hyaluronic acid hydrogel, melt electrowriting of thermoplastic polycaprolactone-polyurethane elastomer, and shape transformation. The combination of the selected materials and fabrication methods allows a number of important advantages such as biocompatibility, biodegradability, and suitable mechanical properties (elasticity and softness of the fibers) similar to those of important components of extracellular matrix (ECM), which allow proper cell alignment and shape transformation. Myoblasts demonstrate excellent viability on the surface of the shapechanging bilayer, where they occupy space between fibers and align along them, allowing efficient cell patterning inside folded structures. The bilayer scaffold is able to undergo a controlled shape transformation and form multilayer scroll-like structures with cells encapsulated inside. Overall, the importance of this approach is the fabrication of tubular constructs with a patterned interior that can support the proliferation and alignment of muscle cells for muscle tissue regeneration.

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Section: Introductionmentioning

confidence: 99%

Shape-Morphing Fibrous Hydrogel/Elastomer Bilayers Fabricated by a Combination of 3D Printing and Melt Electrowriting for Muscle Tissue Regeneration

Uribe-Gomez

Posada-Murcia

Shukla

et al. 2021

ACS Appl. Bio Mater.

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“…These are promising results, which suggest that in the condition of application—in an acidic medium—the gels can fill the necessary volume, but it will not grow out from the available spaces. These findings were essential because in some of the biopolymer-based systems, especially with the presence of PGA, swelling behavior could be higher, sometimes more than 200 or 300% [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

Combined Release of Antiseptic and Antibiotic Drugs from Visible Light Polymerized Biodegradable Nanocomposite Hydrogels for Periodontitis Treatment

et al. 2022

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The in situ application of the combination of different types of drugs revolutionized the area of periodontal therapy. The purpose of this study was to develop nanocomposite hydrogel (NCHG) as a pH-sensitive drug delivery system. To achieve local applicability of the NCHG in dental practice, routinely used blue-light photopolymerization was chosen for preparation. The setting time was 60 s, which resulted in stable hydrogel structures. Universal Britton–Robinson buffer solutions were used to investigate the effect of pH in the range 4–12 on the release of drugs that can be used in the periodontal pocket. Metronidazole was released from the NCHGs within 12 h, but chlorhexidine showed a much longer elution time with strong pH dependence, which lasted more than 7 days as it was corroborated by the bactericidal effect. The biocompatibility of the NCHGs was proven by Alamar-blue test and the effectiveness of drug release in the acidic medium was also demonstrated. This fast photo-polymerizable NCHG can help to establish a locally applicable combined drug delivery system which can be loaded with the required amount of medicines and can reduce the side effects of the systemic use of drugs that have to be used in high doses to reach an ideal concentration locally.

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“…HAm was synthesized as reported . Briefly, HA (0.5 g) was dissolved in 50 mL of deionized (DI) water.…”

Section: Methodsmentioning

confidence: 99%

Reinforcing the Combinational Immuno-Oncotherapy of Switching “Cold” Tumor to “Hot” by Responsive Penetrating Nanogels

Song

Zhang

Wang

et al. 2021

ACS Appl. Mater. Interfaces

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Although immuno-oncotherapy in clinic has gained great success, the immunosuppressive tumor microenvironment (TME) existing in the "cold" tumor with insufficient and exhausted lymphocytes may result in a lower-than-expected therapeutic efficiency. Therefore, a properly designed synergistic strategy that can effectively turn the "cold" tumor to "hot" should be considered to improve the therapeutic effects of immuno-oncotherapy. Herein, TME-responsive penetrating nanogels (NGs) were developed, which can improve the delivery and penetration of the co-loaded resiquimod (R848) and green tea catechin (EGCG) in tumors by a nano-sized controlled releasing system of the soluble cyclodextrin-drug inclusion complex. Consequently, the NGs effectively promoted the maturation of dendritic cells, stimulated the cytotoxic T lymphocytes (CTLs), and decreased the PD-L1 expression in tumors. The combination of NGs with the OX40 agonist (αOX40) further synergistically enhanced the activation and infiltration of CTLs into the deep tumor and inhibited the suppression effects from the regulatory T cells (Tregs). As a result, an increased ratio of active CTLs to Tregs in tumors (20.66-fold) was achieved with a 91.56% tumor suppression effect, indicating a successful switch of "cold" tumors to "hot" for an immunologically beneficial TME with significantly improved anti-tumor immune therapeutics. This strategy could be tailored to other immuno-oncotherapeutic approaches to solve the urgent efficiency concerns of the checkpointbased treatment in clinic.

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Adjustable and ultrafast light-cured hyaluronic acid hydrogel: promoting biocompatibility and cell growth

Abstract:
Bio-sourced hydrogels are attractive materials for diagnosing, repairing and improving the function of human tissues and organs.

Cited by 26 publications

References 31 publications

Shape-Morphing Fibrous Hydrogel/Elastomer Bilayers Fabricated by a Combination of 3D Printing and Melt Electrowriting for Muscle Tissue Regeneration

Shape-Morphing Fibrous Hydrogel/Elastomer Bilayers Fabricated by a Combination of 3D Printing and Melt Electrowriting for Muscle Tissue Regeneration

Combined Release of Antiseptic and Antibiotic Drugs from Visible Light Polymerized Biodegradable Nanocomposite Hydrogels for Periodontitis Treatment

Reinforcing the Combinational Immuno-Oncotherapy of Switching “Cold” Tumor to “Hot” by Responsive Penetrating Nanogels

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Adjustable and ultrafast light-cured hyaluronic acid hydrogel: promoting biocompatibility and cell growth

Abstract: Bio-sourced hydrogels are attractive materials for diagnosing, repairing and improving the function of human tissues and organs.

Cited by 26 publications

References 31 publications

Shape-Morphing Fibrous Hydrogel/Elastomer Bilayers Fabricated by a Combination of 3D Printing and Melt Electrowriting for Muscle Tissue Regeneration

Shape-Morphing Fibrous Hydrogel/Elastomer Bilayers Fabricated by a Combination of 3D Printing and Melt Electrowriting for Muscle Tissue Regeneration

Combined Release of Antiseptic and Antibiotic Drugs from Visible Light Polymerized Biodegradable Nanocomposite Hydrogels for Periodontitis Treatment

Reinforcing the Combinational Immuno-Oncotherapy of Switching “Cold” Tumor to “Hot” by Responsive Penetrating Nanogels

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Product

Resources

About

Abstract:
Bio-sourced hydrogels are attractive materials for diagnosing, repairing and improving the function of human tissues and organs.