Adiposity, depression and anxiety: interrelationship and possible mediators

Gomes, Ana Paula; Soares, Ana Luiza Gonçalves; Menezes, Ana Maria Baptista; Assunção, Maria Cecília Formoso; Wehrmeister, Fernando César; Howe, Laura D; Gonçalves, Helen

doi:10.11606/s1518-8787.2019053001119

Cited by 23 publications

(26 citation statements)

References 29 publications

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“…In this sense, it is interesting to point out that physical exercise can induce molecular modifications which swerve a chronic pro-inflammatory state (which is present both in obesity and depression) to anti-inflammatory one [ 35 ]. So, physical training in obese women does not only cause a reduction of BMI with an amelioration of global health state [ 36 , 37 ], but it is also efficacious in treating mild to moderate depression [ 38 ], inducing increased levels of anti-inflammatory cytokines and of Peroxisome Proliferator-Activated Receptor-Gamma Coactivator Alpha (PGC1α), which reduces the synthesis of pro-inflammatory cytokines [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

The Independent Role of Body Mass Index (BMI) and Severity of Depressive Symptoms on Biological Changes of Women Affected by Overweight/Obesity

Iodice

Ceresa

Esposito

et al. 2021

IJERPH

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Background: Both obesity and depression are medical conditions associated with severe disability and biological abnormalities. Our aim was to study associations between Body Mass Index (BMI), depression and biological changes in women affected by overweight or obesity. Methods: Depressive symptoms were evaluated by the Beck Depression Inventory II (BDI-II) questionnaire in 200 women affected by overweight/obesity (mean age of the sample 52.7 12.9 years, BMI 33.8 5.5 kg/m2). A blood sample was obtained for evaluation of biochemical (oxytocin and vitamin D), inflammatory and epigenetic (methylation of clock genes) parameters. Multivariable linear regression models were used to study the association between BMI or severity of depressive symptoms (BDI-II scores) with different biomarkers. Results: BMI was found to be associated with severity of depressive symptoms (p = 0.050). Severity of obesity resulted to be associated with lower plasma levels of oxytocin (p = 0.053), vitamin D deficiency (p = 0.006) and higher plasma levels of IFN-γ (p = 0.004), IL-6 (p = 0.013), IL-7 (p = 0.013), TNF-alpha (p = 0.036) and chemokine ligand 3 (CCL3) (p = 0.013, R2 = 0.03). Severity of depression was significantly associated with more methylation of clock genes CRY1 (p = 0.034, R2 = 0.16) and CRY2 (p = 0.019, R2 = 0.47). More severe depression together with higher levels of IL-8 strongly predicted lower methylation of CLOCK gene (p = 0.009); Conclusions: Different biological abnormalities have been found to be independently associated with BMI and severity of depressive symptoms in women affected by overweight/obesity. The complex interplay between overweight, depression and biological changes will have to be better clarified by future studies.

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Section: Discussionmentioning

confidence: 99%

The Independent Role of Body Mass Index (BMI) and Severity of Depressive Symptoms on Biological Changes of Women Affected by Overweight/Obesity

Iodice

Ceresa

Esposito

et al. 2021

IJERPH

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“…Numerous factors could elucidate the relationship between obesity and anxiety [ 83 , 84 ], one of which is immune-inflammatory stimulation, as both conditions increase inflammatory biomarkers, such as C-reactive protein (CRP), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) [ 83 ]. Several adjustable lifestyles, such as lower physical activity and unhealthy dietary patterns, are correlated with an increased risk of both obesity and depression/anxiety [ 83 , 84 ]. On the other hand, weight perception, lesser social support, and social networks could augment the risk of anxiety in obese persons [ 82 ].…”

Section: Discussionmentioning

confidence: 99%

Association of depression, anxiety and menopausal-related symptoms with demographic, anthropometric and body composition indices in healthy postmenopausal women

et al. 2021

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Background The termination of the menstrual cycle is correlated with a number of physiological alterations and symptoms that can negatively impact emotion and mood. We aimed to investigate the association of anxiety, depression, and menopausal related symptoms with demographic, anthropometric, and body composition indices in healthy postmenopausal women. Methods A total of 320 menopausal women were selected randomly from referrals of health centers between January and June 2018 in Tabriz/Iran. All participants completed a demographic questionnaire. Bioelectrical impedance analysis was applied to evaluate body fat mass (BFM), soft lean mass (SLM), and lean body mass (LBM) of participants. The modified Kupperman index, Beck's depression inventory-II, and Spielberger’s state-trait anxiety inventory were applied to measure the severity of menopausal-related symptoms, the frequency, and severity of the symptoms of depression and state (SA) and trait anxiety (TA), respectively. Results Finally, 245 postmenopausal women with age of 55.33 ± 4.48 years and body mass index (BMI) of 27.96 ± 3.22 kg/m2 were studied. Women with the age of 55 years and older (OR 3.928, 95% CI 1.504–10.256) and also women with mild physical activity (OR 10.104, 95% CI 3.785–26.976) had a greater possibility of having mild and moderate depression in comparison with women less than 50 years old and women with moderate and severe physical activity. Moderate and severe physical activity was correlated with a lower possibility of having medium upward, relatively severe and severe TA in comparison with participants with mild physical activity in these women (OR 0.372, 95% CI 0.151–0.917). Women with higher BMI and BFM had and more severe menopause-related symptoms (r = 0.143, p = 0.025 and r = 0.139, p = 0.030, respectively) and more severe TA symptoms (r = 0.198, p = 0.018 and r = 0.151, p = 0.021, respectively). Women with lower LBM (r = − 0.139, p = 0.031) and lower SLM (r = − 0.128, p = 0.047) had more severe depressive symptoms. Conclusion Postmenopausal women with higher age and lower physical activity had a greater possibility of having mild and moderate depression. Lower physical activity was also correlated with a greater possibility of having medium upward to severe TA symptoms. Postmenopausal women with higher BMI and BFM had more severe menopause-related and TA symptoms. Women with lower LBM and SLM had more severe depressive symptoms.

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“…Although other studies have demonstrated a relationship between obesity and depression, few studies have shown a definite relationship between anxiety and obesity. [19][20][21] Another study with 94 female participants enrolled in family health centers concluded that obesity increased the risk of anxiety and depression. 22 According to United States National Health and Nutrition study data, there is a positive relationship between BMI and depression, which is significantly noticeable when BMI is 30 kg/m 2 or above.…”

Section: Discussionmentioning

confidence: 99%

Examination of Patients’ Regular Participation at an Obesity Center to Evaluate the Effects on Mental Status and Blood Parameters

Yildirim

Eryılmaz

Aydın³

2020

JOMES

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Background: Obesity is the main cause of type 2 diabetes, coronary artery disease, musculoskeletal disorders, some cancers, and mental disorders, and many other diseases leading to mortality. The aim of this study was to determine the effects of participation in an obesity center on patient mental status and blood parameters within 3 months and to show the relationship of this participation with depression, anxiety, and other parameters. Methods: This was a descriptive and cross-sectional study. Of 2,591 patients admitted to an obesity center between November 1, 2018 and November 1, 2019, 317 met the inclusion criteria. This study was a descriptive and cross-sectional study of the data from those 317 patients. Results: Of the patients enrolled in the study, 90.5% were female and 9.5% were male. Weight, occupation, body mass index, body fat percentage, waist circumference, hip circumference, glycosylated hemoglobin (HbA1c), Beck Depression Scale, and Beck Anxiety Scale were important determinants in our univariate analyses associated with the regular receipt of center education. HbA1c (odds ratio, 1.661; 95% confidence interval, 1.140-2.421; P=0.008) was shown to be multivariate predictors of amount of participation in center education. Conclusion: These results support that regular participation in obesity center education has a positive effect on patients mental status, blood parameters, and anthropometric measurements. Thus, increasing the number of obesity centers is of great importance in treating obesity and improving obese patient mental status.

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Adiposity, depression and anxiety: interrelationship and possible mediators

Cited by 23 publications

References 29 publications

The Independent Role of Body Mass Index (BMI) and Severity of Depressive Symptoms on Biological Changes of Women Affected by Overweight/Obesity

The Independent Role of Body Mass Index (BMI) and Severity of Depressive Symptoms on Biological Changes of Women Affected by Overweight/Obesity

Association of depression, anxiety and menopausal-related symptoms with demographic, anthropometric and body composition indices in healthy postmenopausal women

Examination of Patients’ Regular Participation at an Obesity Center to Evaluate the Effects on Mental Status and Blood Parameters

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