Adiposity and Chronic Inflammation in Young Women Predict Inflammation during Normal Pregnancy in the Philippines

McDade, Thomas W.; Borja, Judith B.; Largado, Fe; Adair, Linda S.; Kuzawa, Christopher W.

doi:10.3945/jn.115.224279

Cited by 25 publications

(26 citation statements)

References 41 publications

(45 reference statements)

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“…There is extensive evidence of a relation between weight gain and low‐grade inflammation in the nongravid population . In line with our results, weight gain during pregnancy has been related to maternal hsCRP levels in some , but not all, previous reports . It is generally accepted that inflammation associated with weight gain is related to secretions of proinflammatory biomarkers from adipose tissue .…”

Section: Discussionsupporting

confidence: 91%

Maternal diet, gestational weight gain, and inflammatory markers during pregnancy

Hrolfsdottir

Schalkwijk

Birgisdóttir

et al. 2016

Obesity

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Section: Discussionsupporting

confidence: 91%

Maternal diet, gestational weight gain, and inflammatory markers during pregnancy

Hrolfsdottir

Schalkwijk

Birgisdóttir

et al. 2016

Obesity

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“…For example, higher TNF-α concentrations have been associated with BP disorders of pregnancy and lower newborn birth weight. 20–24 Long-term follow-up of this cohort to determine the clinical implications for these findings is necessary.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Biomarkers in Youth with Type 2 Diabetes Mellitus: Results from the TODAY Study

Gidding¹,

Bjornstad²,

Katz³

et al. 2018

The Journal of Pediatrics

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Objectives To examine cardiac biomarkers over time in youth-onset type 2 diabetes, and relate serum concentrations to cardiovascular disease risk factors, and left ventricular structure and function. Study design TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) was a multicenter randomized trial of 3 treatments including 521 participants with type 2 diabetes, aged 10–17 years, and with 2–6 years of follow-up. Participants were 36% male, obese, and ethnically diverse. Annual serum concentrations of brain natriuretic peptide, troponin, tumor necrosis factor (TNF)-α, receptors 1 and 2 were related to blood pressure, body mass index, hemoglobin A1c, and left ventricular ejection fraction, diastolic function, relative wall thickness, and mass. Results Elevated concentrations of brain natriuretic peptide (≥100 pg/mL), TNF-α (≥5.6 pg/mL) and troponin (≥0.01 ng/mL), were present in 17.8%, 18.3%, and 34.2% of the cohort, respectively, at baseline, and in 15.4%, 17.1%, and 31.1% at the end of the study, with wide variability over time, without persistence in individuals or clear relationship to glycemia or cardiovascular structure/function. TNF receptors concentrations were increased at baseline and not significantly different from end-of-study concentrations. Adverse echocardiographic measures were more likely in the highest TNF receptor tertile (all P < .05): higher left ventricular mass (39.3 ± 9.0 g/m2.7), left atrial internal dimension (3.7 ± 0.4 cm) and E/Em ratio, a measure of diastolic dysfunction (6.2 ± 1.9). After adjustment for body mass index, these relationships were no longer significant. Conclusions Elevated serum concentrations of cardiac biomarkers were common in youth with type 2 diabetes, but their clinical significance is unclear and will require further long-term study.

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“…Briefly, venipuncture blood samples were collected from n = 1,759 participants in 2005. From these samples we selected n = 395 female participants for DNA methylation analysis, based on their participation in a pregnancy tracking study initiated in 2009 (McDade, Borja, Largado, Adair, & Kuzawa, ). In addition, we randomly selected n = 99 samples from male participants.…”

Section: Methodsmentioning

confidence: 99%

Genome‐wide analysis of DNA methylation in relation to socioeconomic status during development and early adulthood

McDade

Ryan

Jones

et al. 2019

American J Phys Anthropol

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Objectives: Socioeconomic status (SES) is a powerful determinant of health, but the underlying biological mechanisms are poorly understood. This study investigates whether levels of DNA methylation at CpG sites across the genome are associated with SES in a cohort of young adults in the Philippines.Methods: DNA methylation was assayed with the Illumina HumanMethylation450 Bead Chip, in leukocytes from 489 participants in the Cebu Longitudinal Health and Nutrition Survey (mean age = 20.9 years). SES was measured in infancy/childhood and adulthood, and was based on composite measures of income, assets, and education. Genome-wide analysis of variable probes identified CpG sites significantly associated with SES after adjustment for multiple comparisons. Functional enrichment analysis was used to identify biological pathways associated with these sites.Results: A total of 2,546 CpG sites, across 1,537 annotated genes, were differentially methylated in association with SES. In comparison with high SES, low SES was associated with increased methylation at 1,777 sites, and decreased methylation at 769 sites. Functional enrichment analysis identified over-representation of biological pathways related to immune function, skeletal development, and development of the nervous system.Conclusions: Socioeconomic status predicts DNA methylation at a large number of CpG sites across the genome. The scope of these associations is commensurate with the wide range of biological systems and health outcomes that are shaped by SES, and these findings suggest that DNA methylation may play an important role. K E Y W O R D S epigenetics, health disparities, human growth and development

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Adiposity and Chronic Inflammation in Young Women Predict Inflammation during Normal Pregnancy in the Philippines

Cited by 25 publications

References 41 publications

Maternal diet, gestational weight gain, and inflammatory markers during pregnancy

Maternal diet, gestational weight gain, and inflammatory markers during pregnancy

Cardiac Biomarkers in Youth with Type 2 Diabetes Mellitus: Results from the TODAY Study

Genome‐wide analysis of DNA methylation in relation to socioeconomic status during development and early adulthood

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