Adipose tissue resistin levels in patients with anorexia nervosa

Dostálová, I; Kunešová, Marie; Dušková, J; Papežová, Hana; Nedvı́dková, J

doi:10.1016/j.nut.2006.06.006

Cited by 36 publications

(35 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the contrary, the group of Dostalova reported that plasma resistin levels were significantly decreased in AN patients with restrictive subtype of disease when compared to normal-weight controls [16,41]. Notably, plasma resistin levels showed no significant correlation to the percentage of body fat and BMI [41]. Decreased levels of resistin in comparison to the controls were also observed in the study by Krizova et al [32].…”

Section: Prace Oryginalnementioning

confidence: 85%

“…In one study, visfatin levels in the sera of teenage girls with AN were decreased when compared to the results of their healthy counterparts [38]. On the other hand, in another study no differences were observed between visfatin concentration in AN women and in normal-weight controls [39]. In the publication by Seidel et al unchanged values of visfatin were also reported in AN individuals, both at the malnutrition stage and after gaining weight, when compared to the control group [40].…”

Section: Prace Oryginalnementioning

confidence: 89%

“…Housova et al did not reveal any differences in resistin concentration when comparing malnourished individuals with restrictive and the binge/purge subtype of AN with the controls [31]. On the contrary, the group of Dostalova reported that plasma resistin levels were significantly decreased in AN patients with restrictive subtype of disease when compared to normal-weight controls [16,41]. Notably, plasma resistin levels showed no significant correlation to the percentage of body fat and BMI [41].…”

Section: Prace Oryginalnementioning

confidence: 99%

See 2 more Smart Citations

Adipokine profile in patients with anorexia nervosa

Baranowska-Bik

Baranowska

Martyńska

et al. 2017

Endokrynologia Polska

View full text Add to dashboard Cite

Introduction: Anorexia nervosa (AN) is an eating disorder characterised with extremely low weight. Adipokines are adipose tissuederived substances that show a wide spectrum of biological activities. We aimed to assess selected adipokine levels in women with AN before and after nutritional intervention. We also sought to examine whether BMI is the only confounding factor influencing adipokine assessment in AN. Material and methods: Sixty-five women participated in the study: 20 individuals with AN before any treatment, 18 AN patients after nutritional intervention lasting for at least six months, and 27 women as controls. In all participants blood collection and anthropometric measurements were performed. ELISA was used for evaluation of leptin receptor, adiponectin and its isoforms, and resistin. Leptin was assessed with RIA, and visfatin was measured with EIA assay. Results: Leptin and free leptin index (FLI) were lowest in treatment-naïve AN women. HMW-adiponectin and visfatin were enhanced in AN. Other adipokine levels showed no significant differences. When two subsets of anorexia nervosa were compared, only leptin, leptin receptor, and FLI were markedly different. When data were adjusted to BMI, leptin and FLI remained significantly different in the pre-treated AN subgroup when compared with the control group. Conclusions: Our results suggest that leptin is the most important adipokine in AN. It is also important that in our AN population leptin and FLI are the only factors that are influenced not only by the fat content. (Endokrynol Pol 2017; 68 (4): 422-429)

show abstract

Section: Prace Oryginalnementioning

confidence: 85%

Section: Prace Oryginalnementioning

confidence: 89%

Section: Prace Oryginalnementioning

confidence: 99%

See 1 more Smart Citation

Adipokine profile in patients with anorexia nervosa

Baranowska-Bik

Baranowska

Martyńska

et al. 2017

Endokrynologia Polska

View full text Add to dashboard Cite

show abstract

“…Serum adiponectin has been found to be either increased Pannacciulli et al, 2003), normal (Iwahashi et al, 2003) or decreased (Tagami et al, 2004) in AN patients. Likewise, serum plasma resistin levels have been found to be either decreased (Dostalova et al, 2006) or normal (Dolezalova et al, 2007). These discrepancies suggest that some confounding factors, such as eating behaviors and/or physical activity level, could interfere with the results.…”

Section: Introductionmentioning

confidence: 98%

Specific adipocytokines profiles in patients with hyperactive and/or binge/purge form of anorexia nervosa

et al. 2010

View full text Add to dashboard Cite

Objective: The aim of our study was to determine whether eating behaviors and/or physical activity level may explain contradicting results in adipocytokines levels in anorexia nervosa (AN). Subjects/Methods: Fasting levels of circulating adipocytokines (adiponectin, resistin and leptin), insulin, glucose, C-reactive protein, cytokines (tumor necrosis factor-a and interleukin (IL)-1b), body composition and resting energy expenditure were measured in 24 women AN patients and 14 women controls. These parameters were compared according to AN subtypes: 15 patients with restrictive (R-AN) form versus 9 patients with binge/purge (BP-AN) form; 15 patients with hyperactive (H-AN) form versus 9 patients with nonhyperactive (NH-AN) form. Results: BP-AN patients had significantly higher serum adiponectin levels compared with R-AN patients (Po0.05), and H-AN patients had higher serum leptin and lower serum resistin levels compared with NH-AN patients (Po0.05 for both). Conclusions: Our study shows specific adipocytokines profiles depending on the subtype of AN: restrictive versus binge/purge and hyperactive versus Nonhyperactive forms. We suggest that these biological signatures could interfere with the outcome of the disease.

show abstract

“…Based on our in vitro data, we speculate that mutation carriers have a 50% reduction in resistin levels in adipose tissue, although this is not reflected by measured plasma levels. Several studies have, however, already indicated that resistin blood levels do not correlate to resistin adipose tissue levels (39)(40)(41). Therefore, we suspect that a reduction in resistin levels may be present in the adipose tissue, having a local effect on adipogenesis.…”

Section: Discussionmentioning

confidence: 80%

Identification and functional characterization of a missense mutation in resistin in two patients with severe obesity and insulin resistance

Beckers

Freitas²,

Zegers³

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: In this study, we hypothesized that mutations in the resistin encoding gene, RETN, may cause a monogenic form of obesity. Design/methods: We screened the coding region of RETN in 81 morbidly obese adults, 263 overweight and obese children/adolescents, and 116 healthy lean subjects. In vitro experiments include qPCR, ELISA, and western blot for WT and mutant resistin transfected into 3T3-L1 adipocytes. Results: Mutation analysis identified five sequence variants in our patient populations:0 -UTR C100 A/G, T73T, IV3-61 C/A, and C78S. In our control population, we only found the 3 0 -UTR C87 G/A variant. We started functional experiments for the C78S mutation that was found in a 20-year-old obese male (body mass index (BMI)Z39.7 kg/m 2 ) and his obese mother (BMIZ31.9 kg/m 2 ). In vitro testing demonstrated that the mutation does not impair mRNA expression. We identified a 100-fold lower extracellular protein concentration for mutant resistin compared with WT levels using a resistin ELISA on cell culture medium (PZ4.87!10 K6 ). We also detected a decreased intracellular concentration for the mutant protein (tenfold lower relative levels, PZ0.007). The plasma resistin levels of the proband and his mother, however, did not differ significantly from lean control individuals. Conclusions: In conclusion, we identified the first missense mutation in resistin in a morbidly obese proband and his obese mother. Functional testing of the mutant protein suggests that the C78S mutant protein is degraded, possibly resulting in a decreased extracellular concentration, which may predispose to obesity. 164 927-936 European Journal of Endocrinology

show abstract

Adipose tissue resistin levels in patients with anorexia nervosa

Cited by 36 publications

References 42 publications

Adipokine profile in patients with anorexia nervosa

Adipokine profile in patients with anorexia nervosa

Specific adipocytokines profiles in patients with hyperactive and/or binge/purge form of anorexia nervosa

Identification and functional characterization of a missense mutation in resistin in two patients with severe obesity and insulin resistance

Contact Info

Product

Resources

About