Specific adipocytokines profiles in patients with hyperactive and/or binge/purge form of anorexia nervosa

Abstract

Objective: The aim of our study was to determine whether eating behaviors and/or physical activity level may explain contradicting results in adipocytokines levels in anorexia nervosa (AN). Subjects/Methods: Fasting levels of circulating adipocytokines (adiponectin, resistin and leptin), insulin, glucose, C-reactive protein, cytokines (tumor necrosis factor-a and interleukin (IL)-1b), body composition and resting energy expenditure were measured in 24 women AN patients and 14 women controls. These parameters were compared according to AN subtypes: 15 patients with restrictive (R-AN) form versus 9 patients with binge/purge (BP-AN) form; 15 patients with hyperactive (H-AN) form versus 9 patients with nonhyperactive (NH-AN) form. Results: BP-AN patients had significantly higher serum adiponectin levels compared with R-AN patients (Po0.05), and H-AN patients had higher serum leptin and lower serum resistin levels compared with NH-AN patients (Po0.05 for both). Conclusions: Our study shows specific adipocytokines profiles depending on the subtype of AN: restrictive versus binge/purge and hyperactive versus Nonhyperactive forms. We suggest that these biological signatures could interfere with the outcome of the disease.

Adipokine profile in patients with anorexia nervosa

“…However, there was a non-significant tendency towards higher values of adiponectin in AN women independently of the disease phase when compared to the healthy controls. These results are in agreement with those reported by Nogueira et al [26] and Amitani et al [27]. Moreover, in another study conducted by the group of Iwahashi, individuals diagnosed with AN showed a tendency towards higher adiponectin levels than in the control group.…”

“…The authors reported no correlations between concentration of resistin with disease duration and weight restoration [18]. In the study conducted by Nogueira et al no significant difference in serum resistin values was seen in the whole AN group when compared with healthy control women [26]. Housova et al did not reveal any differences in resistin concentration when comparing malnourished individuals with restrictive and the binge/purge subtype of AN with the controls [31].…”

Central and Peripheral Peptides Regulating Eating Behaviour and Energy Homeostasis in Anorexia Nervosa and Bulimia Nervosa: A Literature Review

“…Brain-derived neurotrophic factor The brain-derived neurotrophic factor (BDNF) was originally characterized as a member of the neurotrophin family implicated in the processes of neuronal outgrowth and differentiation, Iwahashi et al (2003), , Tagami et al (2004), Housova et al (2005), Dostálová et al (2007), Dolezalova et al (2007), Nogueira et al (2010) Plasma adiponectin →↓↑ → →↓↑ Cholecystokinin (CCK) Geracioti et al (1992), Tamai et al (1993), Lydiard et al (1993), , Brambilla, Brunetta, Draisci, et al (1995), Fujimoto et al (1997), Walsh (2002), Cuntz et al (2013) Nedvidkova et al (2003), Tanaka, Naruo, et al (2003), , Tanaka, Narau, et al (2003), Nakai et al (2003), Hotta et al (2004), Misra et al (2004), Troisi et al (2005), Otto et al (2005), Stock et al (2005), Kojima et al (2005), Harada et al (2008), Monteleone, Fabrazzo, Tortorella, et al (2005), , Monteleone, Castaldo, et al (2008), , Monteleone et al (2009), Sedlackova et al (2011 Total plasma ghrelin ↑ → ↑ → Total plasma ghrelin (response to test meal or OGT)…”

Neuroendocrine and Molecular Interactions in Eating Disorders

“…Hipotalamusta leptin gibi vücut ağırlığını düzenlemede rol oynayan bir diğer molekül olan adiponektin düzeyleri anoreksiya nervoza tipine göre değişmektedir. [32,33] İlginç olarak, anoreksiya nervozalı hastalarda dolaşımdaki iştah açıcı bir nöropeptid olan AgRP düzeyi yüksek bulunmuş ve AgRP'nin kodlama bölgesindeki bir polimorfizmin anoreksiya nervoza ile ilişkili olduğu gösterilmiştir. [34] Çok yeni bir araştırma-nın sonuçlarına göre, her biri farklı dokuda salınan ve bir kısmının glukoz ve yağ asidi metabolizmasında ayrı ayrı önemli rolleri olan 15 üyeli bir hormon ailesi, C1q/TNFilişkili proteinler, (CTRP1-15) tanımlanmıştır.…”