Adipose Tissue of Control and Ex-Obese Patients Exhibit Differences in Blood Vessel Content and Resident Mesenchymal Stem Cell Population

Baptista, Leandra Santos; Silva, Karina Ribeiro da; Pedrosa, Carolina da S. G.; Claudio-da-Silva, César; Carneiro, João Régis Ivar; Aniceto, Marcelo; Coelho, Valéria de Mello; Takiya, Christina Maeda; Rossi, Maria Isabel D.; Borojević, Radovan

doi:10.1007/s11695-009-9899-2

Cited by 49 publications

(36 citation statements)

References 21 publications

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“…Cells are shown to scale. Pancreatic beta cells (insulin and DNA stained) (76), hepatocytes (β-catenin and DNA stained) (77), keratinocyes from oral tissue (78), fibroblasts (79), adipocytes from subcutaneous tissue (80). …”

Section: Figurementioning

confidence: 99%

On being the right (cell) size

Ginzberg

Kafri

Kirschner

2015

Science

377

379

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Different animal cell types have distinctive and characteristic sizes. How a particular cell size is specified by differentiation programs and physiology remains one of the fundamental unknowns in cell biology. In this review we explore the evidence that individual cells autonomously sense and specify their own size. We discuss possible mechanisms by which size sensing and size specification may take place. Finally, we explore the physiological implications of size control. Why is it important that particular cell types maintain a particular size? We develop these questions by examination of current literature and pose the questions that we anticipate will guide this field in the upcoming years.

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Section: Figurementioning

confidence: 99%

On being the right (cell) size

Ginzberg

Kafri

Kirschner

2015

Science

377

379

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“…Adipose tissue constitutes a more readily available deposit of adult progenitors due to its greater abundance of MSC-like cells, if compared to bone marrow, and because liposuction is a minimally invasive procedure. Known as adipose-derived stromal cells (ADSCs), these cells are isolated by selective adhesion and correspond to the perivascular stromal fraction of the adipose tissue [10], [24], [25]. ADSCs have recently been used to treat SCI in rats and dogs [26]–[28].…”

Section: Introductionmentioning

confidence: 99%

Human Mesenchymal Cells from Adipose Tissue Deposit Laminin and Promote Regeneration of Injured Spinal Cord in Rats

Menezes

Nascimento²,

Gonçalves³

et al. 2014

PLoS ONE

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Cell therapy is a promising strategy to pursue the unmet need for treatment of spinal cord injury (SCI). Although several studies have shown that adult mesenchymal cells contribute to improve the outcomes of SCI, a descripton of the pro-regenerative events triggered by these cells is still lacking. Here we investigated the regenerative properties of human adipose tissue derived stromal cells (hADSCs) in a rat model of spinal cord compression. Cells were delivered directly into the spinal parenchyma immediately after injury. Human ADSCs promoted functional recovery, tissue preservation, and axonal regeneration. Analysis of the cord tissue showed an abundant deposition of laminin of human origin at the lesion site and spinal midline; the appearance of cell clusters composed of neural precursors in the areas of laminin deposition, and the appearance of blood vessels with separated basement membranes along the spinal axis. These effects were also observed after injection of hADSCs into non-injured spinal cord. Considering that laminin is a well-known inducer of axonal growth, as well a component of the extracellular matrix associated to neural progenitors, we propose that it can be the paracrine factor mediating the pro-regenerative effects of hADSCs in spinal cord injury.

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“…There is still little information about the origins of MSCs, but there is a theory that it may be from neuroectodermal origin, from neuroepithelial cells (Takashinma et al 2007). (Ferrari et al 1998;Pittenger et al 1999;Romanov et al 2003;Baptista et al 2009). Adipose tissue represents the ideal source of autologous stem cells, since its acquisition is easy, with minimal discomfort for the patient and often with greater proliferative capacity than the cells derived from bone marrow.…”

Section: Diferentiation Of Mscsmentioning

confidence: 99%