Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity

Nance, Sierra A; Muir, Lindsey A.; Lumeng, Carey N.

doi:10.1016/j.molmet.2022.101642

Cited by 29 publications

(18 citation statements)

References 72 publications

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“…Conversely, M2 macrophages inhibit inflammatory responses mediated by M1 macrophages and contribute to adipocyte insulin sensitivity by producing IL-10. 37 IL-4, an adaptive cytokine within the immune system, is secreted by activated T-cells. It can facilitate the phosphorylation of signal transducer and activator of transcription (STAT) 6, thereby further activating the initiation of the M2 transcriptional program.…”

Section: New Insights Of Glp-1 and Chemerin On Macrophage Polarizatio...mentioning

confidence: 99%

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Progress in the contrary effects of glucagon-like peptide-1 and chemerin on obesity development

Zhang,

Ye,

Wang

2023

Exp Biol Med (Maywood)

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Glucagon-like peptide-1 (GLP-1), secreted by intestinal L-cells, plays a pivotal role in the modulation of β-cell insulin secretion in a glucose-dependent manner, concurrently promoting β-cell survival and β-cell mass. Notably, GLP-1 has emerged as an effective second-line treatment for type 2 diabetes mellitus, gaining further prominence for its pronounced impact on body weight reduction, positioning it as a potent antiobesity agent. However, the mechanism by which GLP-1 improves obesity remains unclear. Some reports suggest that this mechanism may be associated with the regulation of adipokine synthesis within adipose tissue. Chemerin, a multifunctional adipokine and chemokine, has been identified as a pivotal player in adipocyte differentiation and the propagation of systemic inflammation, a hallmark of obesity. This review provides a comprehensive overview of the mechanisms by which GLP-1 and chemerin play crucial roles in obesity and obesity-related diseases. It discusses well-established aspects, such as their effects on food intake and glycolipid metabolism, as well as recent insights, including their influence on macrophage polarization and adipose tissue thermogenesis. GLP-1 has been shown to increase the population of anti-inflammatory M2 macrophages, promote brown adipose tissue thermogenesis, and induce the browning of white adipose tissue. In contrast, chemerin exhibits opposite effects in these processes. In addition, recent research findings have demonstrated the promising potential of GLP-1-based therapies in directly or indirectly regulating chemerin expression. In an intriguing reciprocal relationship, chemerin has also been newly identified as a negative regulator of GLP-1 in vivo. This review delineates the intricate interplay between GLP-1 and chemerin, unraveling their mutual inhibitory interactions. To the best of our knowledge, no previous reviews have focused on this specific topic, making this review particularly valuable in expanding our understanding of the endocrine mechanisms of obesity and providing potential strategies for the treatment of obesity and related diseases.

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Section: New Insights Of Glp-1 and Chemerin On Macrophage Polarizatio...mentioning

confidence: 99%

“…40 To address adipose tissue macrophage-related inflammation and improve adipose tissue function in obesity, potential macrophage-specific therapeutics could focus on decreasing pro-inflammatory M1 macrophages or increasing anti-inflammatory M2 macrophages. 37…”

Section: New Insights Of Glp-1 and Chemerin On Macrophage Polarizatio...mentioning

confidence: 99%

Progress in the contrary effects of glucagon-like peptide-1 and chemerin on obesity development

Zhang,

Ye,

Wang

2023

Exp Biol Med (Maywood)

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“…Numerous researches have reported that adipose tissues are endocrine organs, and their homeostasis is controlled by internal immune cells, including adipose tissue macrophages (ATMs) ( 8 – 10 ). Both macrophages’ recruitment and polarization can regulate the microenvironment in the adipose tissues ( 11 – 14 ).…”

Section: Introductionmentioning

confidence: 99%

“…Classically, ATMs are broadly classified into two types: activated M1 macrophages and alternatively-activated M2 macrophages ( 10 ). Under different microenvironments, AMTs are rapidly capable of adapting through peripheral cell recruitment as well as proliferation.…”

Section: Introductionmentioning

confidence: 99%

The molecular mechanism of macrophage-adipocyte crosstalk in maintaining energy homeostasis

Zhang,

Sun

2024

Front. Immunol.

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Interactions between macrophages and adipocytes in adipose tissue are critical for the regulation of energy metabolism and obesity. Macrophage polarization induced by cold or other stimulations can drive metabolic reprogramming of adipocytes, browning, and thermogenesis. Accordingly, investigating the roles of macrophages and adipocytes in the maintenance of energy homeostasis is critical for the development of novel therapeutic approaches specifically targeting macrophages in metabolic disorders such as obesity. Current review outlines macrophage polarization not only regulates the release of central nervous system and inflammatory factors, but controls mitochondrial function, and other factor that induce metabolic reprogramming of adipocytes and maintain energy homeostasis. We also emphasized on how the adipocytes conversely motivate the polarization of macrophage. Exploring the interactions between adipocytes and macrophages may provide new therapeutic strategies for the management of obesity-related metabolic diseases.

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“…Pro-inflammatory AT resident macrophage polarization caused by still unclear triggers (free-fatty acids, high glucose, Damage-Associated Molecular Patterns (DAMP) from dead adipocytes, GM metabolites etc.) is accompanied by releasing inflammatory mediators, which gradually spread into distant tissues and organs initiating the development of chronic systemic inflammation [ 32 , 33 ]. Pro-inflammatory polarized activation (M1) of these cells causes the recruitment of circulation immune cells into the inflamed tissues and in such a way maintains obesity-associated meta-inflammation [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Multi-probiotic consumption sex-dependently interferes with MSG-induced obesity and concomitant phagocyte pro-inflammatory polarization in rats: Food for thought about personalized nutrition

Rudyk¹,

Hurmach²,

Serhiichuk³

et al. 2023

Heliyon

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Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity

Cited by 29 publications

References 72 publications

Progress in the contrary effects of glucagon-like peptide-1 and chemerin on obesity development

Progress in the contrary effects of glucagon-like peptide-1 and chemerin on obesity development

The molecular mechanism of macrophage-adipocyte crosstalk in maintaining energy homeostasis

Multi-probiotic consumption sex-dependently interferes with MSG-induced obesity and concomitant phagocyte pro-inflammatory polarization in rats: Food for thought about personalized nutrition

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