Adipose tissue is a regulated source of interleukin-10

Juge-Aubry, Cristiana E.; Somm, Emmanuel; Pernin, Agnès; Alizadeh, Navid; Giusti, Vittorio; Dayer, Jean‐Michel; Meier, Christoph A.

doi:10.1016/j.cyto.2004.10.017

Cited by 87 publications

(91 citation statements)

References 19 publications

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“…Insulted tissues generate not only proinflammatory cytokines but also anti-inflammatory molecules to resolve local and systemic inflammation (34). Accordingly, inflamed adipose tissue in obese animal models exhibits increased expression of several anti-inflammatory molecules such as IL-10, IL-1Ra, and stamp2 as well as proinflammatory cytokines to counterbalance the proinflammatory events (35,36). However, the regulatory mechanisms and the roles of the anti-inflammatory molecules following changes of energy balance in the adipose tissue are poorly understood.…”

Section: Discussionmentioning

confidence: 99%

Adipocytokine Orosomucoid Integrates Inflammatory and Metabolic Signals to Preserve Energy Homeostasis by Resolving Immoderate Inflammation

Lee

Choi

Hwang

et al. 2010

Journal of Biological Chemistry

112

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Orosomucoid (ORM), also called ␣-1 acid glycoprotein, is an abundant plasma protein that is an immunomodulator induced by stressful conditions such as infections. In this study, we reveal that Orm is induced selectively in the adipose tissue of obese mice to suppress excess inflammation that otherwise disturbs energy homeostasis. Adipose Orm levels were elevated by metabolic signals, including insulin, high glucose, and free fatty acid, as well as by the proinflammatory cytokine tumor necrosis factor-␣, which is found in increased levels in the adipose tissue of morbid obese subjects. In both adipocytes and macrophages, ORM suppressed proinflammatory gene expression and pathways such as NF-B and mitogen-activated protein kinase signalings and reactive oxygen species generation. Concomitantly, ORM relieved hyperglycemia-induced insulin resistance as well as tumor necrosis factor-␣-mediated lipolysis in adipocytes. Accordingly, ORM improved glucose and insulin tolerance in obese and diabetic db/db mice. Taken together, our results suggest that ORM integrates inflammatory and metabolic signals to modulate immune responses to protect adipose tissue from excessive inflammation and thereby from metabolic dysfunction.

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Section: Discussionmentioning

confidence: 99%

Adipocytokine Orosomucoid Integrates Inflammatory and Metabolic Signals to Preserve Energy Homeostasis by Resolving Immoderate Inflammation

Lee

Choi

Hwang

et al. 2010

Journal of Biological Chemistry

112

View full text Add to dashboard Cite

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“…This cytokine can act on almost all types of nucleated cells, either through two types of membrane receptors', type I (TNFR-1, p55) and type II (TNFR-2, p75), or as a soluble molecule. 9 The transmission of the signal mediated by TNF-a binding to its membrane receptors constitutes a highly complex and diverse phenomenon, mediated by reactions involving phosphorylation and ubiquitination of target proteins. After TNF-a binding to its receptor, the activation of TRAF (TNF receptor-associated factor, a ubiquitin ligase) 2-and/or 5-protein, seems to be essential for the activation of its intermediary signalling protein RIP (receptor interacting protein), through polyubiquitination of the protein.…”

Section: Cancer Cachexia and Cytokine Profilementioning

confidence: 99%

“…The balance between the secretion of pro-and antiinflammatory factors essentially depends on the stimulus and on the location of the adipose tissue depot. [7][8][9][10][11] Argilés et al 1 proposed the adoption of the balance of proand anti-inflammatory cytokines as markers of the severity of cancer cachexia. Recently, the IL-10/TNF-a ratio has been adopted as a marker of the intensity of the inflammatory condition in obese individuals and animals.…”

Section: Introductionmentioning

confidence: 99%

Regulation of inflammation in the adipose tissue in cancer cachexia: effect of exercise

Lira

Rosa

Zanchi

et al. 2009

Cell Biochemistry & Function

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The paraneoplastic syndrome of cachexia is considered a degenerative chronic inflammatory disease, being deeply related to the increase of pro-inflammatory factors, especially tumour necrosis factor alpha (TNF-a). It is known that the adipose tissue is affected by cachexia and contributing with the secretion of pro-inflammatory factors which reach the adjacent tissues and the circulation. The effect of proinflammatory factors is balanced by the effect of anti-inflammatory factors, such as interleukin 10 (IL-10). The IL-10/TNF-a ratio has been recently postulated as a marker for the assessment of the degree of inflammation, which correlates with disease-associated morbidity and mortality. In order to counteract inflammation in chronic disease, our group has currently adopted chronic endurance exercise in models of cancer cachexia and chronic heart failure. Since it is clear that white adipose tissue is strongly implicated in the secretion of both pro-and antiinflammatory factors in disease, we chose to address its contribution to cachexia-related inflammation and the effect of endurance training on the capacity of cytokine expression and secretion by this tissue. Our results show an enhancement of IL-10 adipose tissue content, and increased IL-10/TNF-a ratio induced by endurance training. The mechanisms are discussed.

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“…To investigate whether inflammation in transplanted fat was regulated by the same factors proposed to affect inflammation in endogenous fat such as MCP-1, 13 IL-10, secreted by various cell types, including adipocytes, 15 is an antiinflammatory cytokine with deactivating effects on T cells and macrophages. 16 To study the effect of IL-10 on adipose tissue inflammation in this transplant model, we used Il-10 Ϫ/Ϫ mice as fat donors for Wt recipient mice (nϭ3).…”

Section: Regulation Of Macrophage Recruitment In Transplanted Adiposementioning

confidence: 99%

Visceral Adipose Tissue Inflammation Accelerates Atherosclerosis in Apolipoprotein E–Deficient Mice

et al. 2008

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Background-Fat inflammation may play an important role in comorbidities associated with obesity such as atherosclerosis. Methods and Results-To first establish feasibility of fat transplantation, epididymal fat pads were harvested from wild-type C57BL/6J mice and transplanted into leptin-deficient (Lep ob/ob ) mice. Fat transplantation produced physiological leptin levels and prevented obesity and infertility in Lep ob/ob mice. However, the transplanted fat depots were associated with chronically increased macrophage infiltration with characteristics identical to those observed in fat harvested from obese animals. The inflammation in transplanted adipose depots was regulated by the same factors that have been implicated in endogenous fat inflammation such as monocyte chemoattractant protein-1. To determine whether this inflamed adipose depot could affect vascular disease in mice, epididymal fat depots were transplanted into atherosclerosis-prone apolipoprotein E-deficient ApoE Ϫ/Ϫ mice. Plasma from ApoE Ϫ/Ϫ mice receiving fat transplants contained increased leptin, resistin, and monocyte chemoattractant protein-1 compared with plasma from sham-operated ApoE Ϫ/Ϫ mice. Furthermore, mice transplanted with visceral fat developed significantly more atherosclerosis compared with sham-operated animals, whereas transplants with subcutaneous fat did not affect atherosclerosis despite a similar degree of fat inflammation. Treatment of transplanted ApoE Ϫ/Ϫ mice with pioglitazone decreased macrophage content of the transplanted visceral fat pad and reduced plasma monocyte chemoattractant protein-1. Importantly, pioglitazone also reduced atherosclerosis triggered by inflammatory visceral fat but had no protective effect on atherosclerosis in the absence of the visceral fat transplantation. Conclusions-Our

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Adipose tissue is a regulated source of interleukin-10

Cited by 87 publications

References 19 publications

Adipocytokine Orosomucoid Integrates Inflammatory and Metabolic Signals to Preserve Energy Homeostasis by Resolving Immoderate Inflammation

Adipocytokine Orosomucoid Integrates Inflammatory and Metabolic Signals to Preserve Energy Homeostasis by Resolving Immoderate Inflammation

Regulation of inflammation in the adipose tissue in cancer cachexia: effect of exercise

Visceral Adipose Tissue Inflammation Accelerates Atherosclerosis in Apolipoprotein E–Deficient Mice

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