Adipose tissue estrogen production and metabolism in premenopausal women

Hetemäki, Natalia; Mikkola, Tomi S.; Tikkanen, Matti J.; Wang, Feng; Hämäläinen, Esa; Turpeinen, Ursula; Haanpää, Mikko; Vihma, Veera; Savolainen-Peltonen, Hanna

doi:10.1016/j.jsbmb.2021.105849

Cited by 55 publications

(45 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Estradiol was quantitated by LC-MS/MS using a TQ5500 mass spectrometer (AB Sciex). The between-run CV% were 4.5-5.7% for serum samples at concentrations of 317-898 pmol/L and the detection limit was 0.01 nmol/L ( 28 ). DHEAS sample extracts were measured using a direct chemiluminescent immunoassay (Siemens Atellica OM 1600 Analyzer).…”

Section: Methodsmentioning

confidence: 99%

Endocrine Disorders and Genital Infections Impair Gynecological Health in APECED (APS-1)

et al. 2021

View full text Add to dashboard Cite

ObjectiveIn autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) defects in the autoimmune regulator gene lead to impaired immunotolerance. We explored the effects of immunodeficiency and endocrinopathies on gynecologic health in patients with APECED.DesignCross-sectional cohort study combined with longitudinal follow-up data.MethodsWe carried out a gynecologic evaluation, pelvic ultrasound, and laboratory and microbiologic assessment in 19 women with APECED. Retrospective data were collected from previous study visits and hospital records.ResultsThe study subjects’ median age was 42.6 years (range, 16.7-65.5). Sixteen patients (84%) had premature ovarian insufficiency, diagnosed at the median age of 16.5 years; 75% of them used currently either combined contraception or hormonal replacement therapy. In 76% of women, the morphology and size of the uterus were determined normal for age, menopausal status, and current hormonal therapy. Fifteen patients (79%) had primary adrenal insufficiency; three of them used dehydroepiandrosterone substitution. All androgen concentrations were under the detection limit in 11 patients (58%). Genital infections were detected in nine patients (47%); most of them were asymptomatic. Gynecologic C. albicans infection was detected in four patients (21%); one of the strains was resistant to azoles. Five patients (26%) had human papillomavirus infection, three of which were high-risk subtypes. Cervical cell atypia was detected in one patient. No correlation between genital infections and anti-cytokine autoantibodies was found.ConclusionsOvarian and adrenal insufficiencies manifested with very low androgen levels in over half of the patients. Asymptomatic genital infections, but not cervical cell atypia, were common in female patients with APECED.

show abstract

Section: Methodsmentioning

confidence: 99%

Endocrine Disorders and Genital Infections Impair Gynecological Health in APECED (APS-1)

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Estrogens enhance preadipocyte proliferation and differentiation into insulin-sensitive adipocytes and inhibit lipolysis, while androgens exert opposite functions. Moreover, the development and regulation of the fat depots in the female body are controlled by complex interactions between adipose tissue genes and ovarian hormones [ 60 ]. Gender differences are also noticed in adipogenesis.…”

Section: Adipose Tissuementioning

confidence: 99%

Metabolic Obesity in People with Normal Body Weight (MONW)—Review of Diagnostic Criteria

Pluta

Dudzińska

Lubkowska

2022

IJERPH

View full text Add to dashboard Cite

Disorders of metabolic obesity with normal body weight (MONW) are widely recognized risk factors for the development of cardiovascular diseases and type 2 diabetes. Despite this, MONW is not diagnosed in clinical practice. There is no consensus on the definition of MONW, and measuring the degree of insulin resistance or obesity among apparently healthy, non-obese patients is not widely applicable. The awareness of the relationship between metabolic disorders such as MONW and a higher risk of mortality from cardiovascular causes and other related diseases prompts the need for action to be taken aimed at creating appropriate diagnostic models that will allow for the effective detection of those with metabolic abnormalities among people with normal body weight. Such actions are decisive in the prevention and treatment of diseases. Therefore, the purpose of this article is to review the MONW diagnostic criteria used over the years.

show abstract

“…In breast adipose tissue specifically, mRNA expression of aromatase correlated positively with BMI ( Savolainen-Peltonen et al, 2018 ). Additionally, a survey of adipose depots in pre-menopausal women found that a higher waist circumference is associated with significantly increased estradiol in subcutaneous adipose tissue ( Hetemäki et al, 2021 ). Increased aromatase and estrogen provide requisite ligands for estrogen receptor-positive breast cancer.…”

Section: Ascs and Adipocytes In Breast Cancermentioning

confidence: 99%

A Role for Adipocytes and Adipose Stem Cells in the Breast Tumor Microenvironment and Regenerative Medicine

et al. 2021

View full text Add to dashboard Cite

Obesity rates are climbing, representing a confounding and contributing factor to many disease states, including cancer. With respect to breast cancer, obesity plays a prominent role in the etiology of this disease, with certain subtypes such as triple-negative breast cancer having a strong correlation between obesity and poor outcomes. Therefore, it is critical to examine the obesity-related alterations to the normal stroma and the tumor microenvironment (TME). Adipocytes and adipose stem cells (ASCs) are major components of breast tissue stroma that have essential functions in both physiological and pathological states, including energy storage and metabolic homeostasis, physical support of breast epithelial cells, and directing inflammatory and wound healing responses through secreted factors. However, these processes can become dysregulated in both metabolic disorders, such as obesity and also in the context of breast cancer. Given the well-established obesity-neoplasia axis, it is critical to understand how interactions between different cell types in the tumor microenvironment, including adipocytes and ASCs, govern carcinogenesis, tumorigenesis, and ultimately metastasis. ASCs and adipocytes have multifactorial roles in cancer progression; however, due to the plastic nature of these cells, they also have a role in regenerative medicine, making them promising tools for tissue engineering. At the physiological level, the interactions between obesity and breast cancer have been examined; here, we will delineate the mechanisms that regulate ASCs and adipocytes in these different contexts through interactions between cancer cells, immune cells, and other cell types present in the tumor microenvironment. We will define the current state of understanding of how adipocytes and ASCs contribute to tumor progression through their role in the tumor microenvironment and how this is altered in the context of obesity. We will also introduce recent developments in utilizing adipocytes and ASCs in novel approaches to breast reconstruction and regenerative medicine.

show abstract

Adipose tissue estrogen production and metabolism in premenopausal women

Cited by 55 publications

References 30 publications

Endocrine Disorders and Genital Infections Impair Gynecological Health in APECED (APS-1)

Endocrine Disorders and Genital Infections Impair Gynecological Health in APECED (APS-1)

Metabolic Obesity in People with Normal Body Weight (MONW)—Review of Diagnostic Criteria

A Role for Adipocytes and Adipose Stem Cells in the Breast Tumor Microenvironment and Regenerative Medicine

Contact Info

Product

Resources

About