Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs and CTRPs

Schäffler, Andréas; Schölmerich, Jürgen; Salzberger, Bernd

doi:10.1016/j.it.2007.07.003

Cited by 219 publications

(176 citation statements)

References 66 publications

(108 reference statements)

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“…Immune cells infiltrating fat create a milieu that perpetuates inflammation within the adipose tissue and stimulates the adipocytes themselves to produce inflammatory mediators, including adipokines, completing a vicious circle of inflammation related to obesity [65][66][67][68].…”

Section: Resistin Obesity and Markers Of Insulin Resistancementioning

confidence: 99%

The role of resistin as a regulator of inflammation: Implications for various human pathologies

Filková

Haluzı́k

Šenolt

2009

Clinical Immunology

372

297

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Section: Resistin Obesity and Markers Of Insulin Resistancementioning

confidence: 99%

The role of resistin as a regulator of inflammation: Implications for various human pathologies

Filková

Haluzı́k

Šenolt

2009

Clinical Immunology

372

297

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“…Adipocytes express TLRs (and CD14) and thereby could play an active role in the innate immune system (Schäffler et al, 2007). The characterisation of a variety of complement proteins generated by adipose tissue contributes to this concept.…”

Section: Role Of Complement In Homoiostasis and Immune Defense Of Adimentioning

confidence: 99%

Dual role of complement in adipose tissue

Pattrick

Luckett

Yue

et al. 2009

Molecular Immunology

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Once thought of as purely the body's chief energy store, adipose tissue and its constituent adipocytes have emerged as both a metabolic entity and an endocrine one.Complement is generally thought of as originating mainly from hepatic synthesis but also from synthesis by the macrophage phagocyte system. This review revisits early descriptions of adipocytic synthesis of complement components and highlights the need of a systematic analysis of the contribution of adipose tissue to systemic inflammation in order to appreciate the immunological activity of this tissue. AbstractOnce thought of as purely the body's chief energy store, adipose tissue and its constituent adipocytes have emerged as both a metabolic entity and an endocrine one.Complement is generally thought of as originating mainly from hepatic synthesis but also from synthesis by the macrophage phagocyte system. This review revisits early descriptions of adipocytic synthesis of complement components and highlights the need of a systematic analysis of the contribution of adipose tissue to systemic inflammation in order to appreciate the immunological activity of this tissue.

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“…On a cellular basis, whether there is a relationship between hypertrophy and hyperproliferation mediated by a maximum cell size or other molecular trigger remains to be definitively resolved. Further, the complement of cells that give rise to adipose tissue and under what circumstances remains to be experimentally shown [5,6].…”

Section: Editorialmentioning

confidence: 99%

Flow Cytometry and Adipose Mesenchymal Stem Cells Characterization

Kalodimou¹

2015

Cardiol Pharmacol

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Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs and CTRPs

Cited by 219 publications

References 66 publications

The role of resistin as a regulator of inflammation: Implications for various human pathologies

The role of resistin as a regulator of inflammation: Implications for various human pathologies

Dual role of complement in adipose tissue

Flow Cytometry and Adipose Mesenchymal Stem Cells Characterization

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