Adipose stromal cells-conditional medium protected glutamate-induced CGNs neuronal death by BDNF

Magnetic resonance imaging monitoring dual-labeled stem cells for treatment of mouse nerve injury

“…This result indicates that the ADSCs contributed to regeneration of the injured nerves, but the underlying mechanisms are unclear. Thus far, some studies considered that the release of soluble nerve growth factors or angiogenic molecules from stem cells could aim for nerve regeneration (37,38).…”

The use of undifferentiated bone marrow stromal cells for sciatic nerve regeneration in rats

“…apy. Stem cells could aid regeneration by transdifferentiation into Schwann cells or the release of soluble nerve growth factors such as brain-derived neurotrophic factor or angiogenic molecules, including vascular endothelial growth factor 18,25,32 . It has previously shown that only differentiated bone marrow stromal cells, rather than untreated BMSCs, can stimulate nerve regeneration 11,18,30 .…”

TIMP1 in conditioned media of human adipose stromal cells protects neurons against oxygen-glucose deprivation injury

“…To neutralize the activity of TIMP1, 1 g/l of polyclonal antibody against TIMP1 (R&D System, Minneapolis, MN, USA) was incubated with ASC-CM overnight at 4 • C [35]. ASC-CM was used to pretreat cortical neurons for 1 h before OGD.…”

“…Recently, adipose-derived stem cells (ASC) from mice, rats, nonhuman primates, and humans were demonstrated to differentiate into cells with neural and glial markers in vivo and in vitro [2,7,17,18,[22][23][24]27,36]. In addition to their pluripotency, ASC were reported to secrete many neurotrophic factors including brain-derived neurotropic factor (BDNF), nerve growth factor (NGF), vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), and insulin-like growth factor-1 (IGF-1) to protect neurons [19,21,30,35].…”