Adipose expression of miR-130b and miR-17-5p with wasting, cardiovascular event and mortality in advanced chronic kidney disease patients

Chan, George C.-Y.; Than, Win Hlaing; Kwan, Bonnie Ching-Ha; Lai, Ka-Bik; Chan, Ronald; Ng, Jack Kit‐Chung; Chow, Kai‐Ming; Cheng, Phyllis Mei-Shan; Law, Man-Ching; Leung, Chi-Bon; Li, Philip Kam-Tao; Szeto, Cheuk‐Chun

doi:10.1093/ndt/gfab287

Cited by 12 publications

(10 citation statements)

References 45 publications

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“…Chan et al demonstrated that miRNA-130b expression in adipose tissue decreased from nonfrail to severe frailty (1.01-fold vs. 0.32-fold, p=0.031) and predicted frailty independent of age and serum albumin level in patients with advanced chronic kidney disease. 34 It is tempting to conduct in-depth investigations of miRNA perturba-tion, adipose tissue distribution, and frail phenotype in the context of cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

Dissecting the Contributing Role of Divergent Adipose Tissue to Multidimensional Frailty in Cirrhosis

Mao¹,

Li²,

Wang³

et al. 2022

J Clin Transl Hepatol

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Background and Aims:Emerging evidence has demonstrated that abnormal body composition may potentiate the development of frailty, whereas little work focuses on the role of divergent adipose tissue. Therefore, we aimed to determine the potential contribution of adipose tissue distribution to multidimensional frailty in decompensated cirrhosis. Methods: We conducted a retrospective cohort study. Divergent adipose tissues were assessed by computed tomography-derived subcutaneous adipose tissue index (SATI), visceral adipose tissue index (VATI) and total adipose tissue index (TATI), respectively. Frailty was identified by our validated self-reported Frailty Index. Multiple binary logistic models incorporating different covariates were established to assess the relationship between adipose tissue distribution and frailty. Results: The study cohort comprised 245 cirrhotic patients with 45.3% being male. The median Frailty Index, body mass index (BMI) and model for end-stage liver disease (MELD) score were 0.11, 24.3 kg/m 2 and 8.9 points, respectively. In both men and women, patients who were frail exhibited lower levels of SATI in comparison with nonfrail patients. SATI inversely correlated with Frailty Index in the entire cohort (r s =−0.1361, p=0.0332). Furthermore, SATI or TATI was independently associated with frail phenotype in several multiple logistic regression models adjusting for age, BMI, presence of ascites, sodium, Child-Pugh class or MELD score in isolation. Conclusions: In the context of decompensated cirrhosis, low SATI and concomitant TATI were associated with higher risk of being frail. These findings highlight the importance to further apply tissue-specific tools of body composition in place of crude metric like BMI.

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Section: Discussionmentioning

confidence: 99%

Dissecting the Contributing Role of Divergent Adipose Tissue to Multidimensional Frailty in Cirrhosis

Mao¹,

Li²,

Wang³

et al. 2022

J Clin Transl Hepatol

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“…19) Another study showed that adipose microRNA expression (MiR-130b) predicted frailty and incidence of MACE in advanced CKD patients. 20) Low BMI is due to various factors, such as malnutrition, chronic inflammation, cachexia, or frailty. The prevalence of frailty and prefrailty in hospitalized elderly patients with multimorbidity was high.…”

Section: Discussionmentioning

confidence: 99%

Low Body Mass Index without Malnutrition Is an Independent Risk Factor for Major Cardiovascular Events in Patients with Hemodialysis

et al. 2022

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We retrospectively analyzed major cardiovascular events (MACE), a composite of cardiac death, nonfatal myocardial infarction, unplanned revascularization, heart failure leading to hospitalization, and stroke during a 3-year follow-up of patients with hemodialysis at the dialysis center of our general hospital that can treat comprehensive diseases. Moreover, we conducted an exploratory study that focuses on the risk factor for MACE in patients with hemodialysis.A total of 132 patients with hemodialysis at our dialysis center as of June 2017 were included in the study. Data on event incidence, including death and various clinical indicators, were collected in the electronic medical record for three years until June 2020. Between June 2017 and June 2020, of the 132 patients with hemodialysis, 31 patients experienced MACE (10 cardiovascular deaths, 3 nonfatal myocardial infarction, 11 unplanned revascularizations, 5 heart failure leading to hospitalization, and 2 stroke). The patients with MACE had a lower body mass index (BMI), longer duration of dialysis with more preexisting gastrointestinal (GI) bleeding, and took more aspirin compared to the MACE-free patients. Malnutrition markers (serum total protein, serum albumin, and serum total cholesterol) were similar in both groups. In a univariate analysis for MACE, the odds ratio was significantly higher for BMI < 18.5, duration of hemodialysis, and history of GI bleeding. Multivariableadjusted odds ratios for MACE were significantly higher for BMI < 18.5.In conclusion, BMI < 18.5 without malnutrition may be an independent risk factor for MACE in patients with hemodialysis.

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“…MiR-124-3p, a tumor-suppressive miRNA that targets CRKL, suppresses HCC carcinogenesis [ 102 ]. Adipose miR-130b and miR-17-5p expression in severe patients with CKD were linked to body composition characteristics, frailty, and predicted cardiovascular events and death [ 103 ]. Wang et al discovered miR-130b as a possible biomarker for OB, hypertriacylglycerolemia, and metabolic disease [ 98 ].…”

Section: Discussionmentioning

confidence: 99%

System biology approaches identified novel biomarkers and their signaling pathways involved in renal cell carcinoma with different human diseases

Hossen

Samad²,

Ahammad

et al. 2022

Bioscience Reports

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Renal cell carcinoma (RCC) is a type of cancer that develops in the renal epithelium of the kidney. It is responsible for approximately 3% of adult malignancies, and 90-95% of neoplasms originate from the kidney. Advances in tumor diagnosis, innovative immune therapeutics, and checkpoint inhibitors-based treatment options improved the survival rate of patients with RCC accompanied by different risk factors. RCC Patients with diabetes, hepatitis C virus (HCV), or obesity (OB) may have a comorbidity, and finding the risk factor for better clinical treatment is an urgent issue. Therefore, the study focused on network-based gene expression analysis approaches to learning the impact of RCC on other comorbidities associated with the disease. The study found critical genetic factors and signal transduction pathways that share pathophysiology and commonly use dysregulated genes of the illness. Initially, the study identified 385 upregulated genes and 338 down-regulated genes involved with RCC. OB, chronic kidney disease (CKD), type 2 diabetes (T2D), and HCV significantly shared 28, 14, 5, and 3 genes, respectively. RCC shared one downregulated gene versican (VCAN) with OB and HCV and one downregulated gene oxidase homolog 2 (LOXL2) with OB and CKD. Interestingly, most of the shared pathways were linked with metabolism. The study also identified six prospective biomarkers, signaling pathways, and numerous critical regulatory and associated drug candidates for the disease. We believe that the discovery will help explain these diseases' complicated interplay and aid in developing novel therapeutic targets and drug candidates.

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Adipose expression of miR-130b and miR-17-5p with wasting, cardiovascular event and mortality in advanced chronic kidney disease patients

Cited by 12 publications

References 45 publications

Dissecting the Contributing Role of Divergent Adipose Tissue to Multidimensional Frailty in Cirrhosis

Dissecting the Contributing Role of Divergent Adipose Tissue to Multidimensional Frailty in Cirrhosis

Low Body Mass Index without Malnutrition Is an Independent Risk Factor for Major Cardiovascular Events in Patients with Hemodialysis

System biology approaches identified novel biomarkers and their signaling pathways involved in renal cell carcinoma with different human diseases

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