Adiponectin mitigates the severity of arthritis in mice with collagen‐induced arthritis

Sw, Lee; Kim, Jin‐Hoi; Mc, Park; Yb, Park; Sk, Lee

doi:10.1080/03009740801910346

Cited by 70 publications

(54 citation statements)

References 24 publications

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“…On the other hand, the high adiponectin levels of patients with RA can also be interpreted as an attempt to overcome the well-known pro-inflammatory effect of leptin, for example by counteracting the proinflammatory effects of TNF-a and reducing the production of IL 6 and C reactive protein in RA. In keeping with this data, recent reports showed that adiponectin mitigates the severity of collagen-induced arthritis in mice (Lee et al 2008) whereas another work showed that Etanercept (a soluble fusion protein that specifically binds to TNF-a) treatment in RA patients is able to increase adiponectin levels in women with RA (Lewicki et al 2008). This finding has been also suggested by another author using another anti TNF-a treatment such as infliximab (Nagashima et al 2008).…”

Section: Adiponectinmentioning

confidence: 57%

Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases

Gómez

Lago²,

Gómez-Reino³

et al. 2009

Journal of Molecular Endocrinology

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The discovery of leptin in 1994 marked the beginning of a new understanding about white adipose tissue (WAT) and modified a static vision of this tissue which was viewed up to the end of the 20th century as an inert tissue, devoted to body protection from heat loss and to passively storing energy. The identification of the product of the gene obese accentuated the role of adipose tissue in the physiopathology of obesity-linked diseases, and led to the discovery of various adipokines, many of a pro-inflammatory nature. It has become progressively manifest that WAT-derived adipokines can now be considered as the fulcrum between obesity-related environmental causes, such as nutrition and lifestyle, and the biochemical shifts that lead to metabolic syndrome, inflammatory and/or autoimmune conditions, and rheumatic diseases. Herein, we review recent adipokine research, with particular emphasis to the role of leptin, adiponectin, resistin, and visfatin in chondrocyte function and skeleton, as well as in inflammatory and degenerative cartilage joint diseases.

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Section: Adiponectinmentioning

confidence: 57%

Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases

Gómez

Lago²,

Gómez-Reino³

et al. 2009

Journal of Molecular Endocrinology

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show abstract

“…In contrast, Lee et al observed, that adiponectin significantly mitigated the severity of arthritis in collagen-induced arthritis in mice, with decreased expression of TNF-α, IL-1β, MMP-3 in RA synovial fibroblasts. These data suggest an anti-inflammatory adiponectin role in the pathophysiology of RA [38]. 10 In clinical observations, it was reported, that adiponectin plasma levels of RA pts did not differ significantly [21] or were markedly increased in comparison with healthy controls [21,27].…”

Section: Discussionmentioning

confidence: 85%

Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis

2009

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International audienceAdipose tissue is regarded as an active metabolic and endocrine organ producing adipokines. The purpose of the study was to evaluate adiponectin and leptin concentrations in rheumatoid arthritis (RA) patients (pts) in relation to disease duration and activity. The study group consisted of 80 RA pts. Serum adiponectin and leptin concentrations remained within normal ranges. Adiponectin concentration correlated positively both with the age and disease duration. Both adipokines levels correlated negatively with glomerular filtration rate. There were significant positive correlations between adipokines' concentrations and lipid profile components (between adiponectin and HDL-cholesterol, leptin and total cholesterol and LDL-cholesterol). In pts with long-standing RA, there was a negative correlation between adiponectin and numbers of tender, swollen joints and a positive relationship between leptin level and DAS28. The results confirm adipokines' involvement in the process of inflammation and atherosclerosis: protective and antiinflammatory adiponectin effect and proatherogenic and proinflammatory leptin function

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“…In contrast to the results in vitro, in the primarily inflammation-driven arthritis model of collagen-induced arthritis (CIA), gene transfer or intraarticular injection of adiponectin resulted in a reduction in the severity of arthritis in mice with CIA (37,38). When the adenoviral vector was applied prior to progression of arthritis, the histology scores for inflammation and joint erosion were significantly decreased without alteration of the anticollagen levels (37).…”

Section: Adiponectin In Ramentioning

confidence: 80%

Adipocytokines as driving forces in rheumatoid arthritis and related inflammatory diseases?

Neumann

Frommer

Vasile

et al. 2011

Arthritis & Rheumatism

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Adiponectin mitigates the severity of arthritis in mice with collagen‐induced arthritis

Abstract: These data suggest that AD may play an anti-inflammatory role in the pathophysiology of RA.

Cited by 70 publications

References 24 publications

Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases

Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases

Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis

Adipocytokines as driving forces in rheumatoid arthritis and related inflammatory diseases?

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