Adiponectin levels may help assess the clinical repercussions of obesity irrespective of body mass index

Dermitzaki, Eirini; Avgoustinaki, Pavlina; Spyridaki, Eirini; Simos, Panagiotis G.; Malliaraki, Niki; Venihaki, Maria; Tsatsanis, Christos; Margioris, Andrew N.

doi:10.14310/horm.2002.1746

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…The decrease in adiponectin level observed in the control group because these children were obese or overweight. Adiponectin levels have been reported by many authors to be low in obese patients without NAFLD [2021].…”

Section: Discussionmentioning

confidence: 99%

Role of Soluble Adiponectin Receptor 2 in Non-Alcoholic Fatty Liver Disease in Children

Aksoy

Artan

Aksoy

et al. 2019

Pediatr Gastroenterol Hepatol Nutr

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PurposeThe incidence of non-alcoholic fatty liver disease (NAFLD) in children is gradually increasing. The aim of this study was to investigate the use of serum adiponectin and soluble adiponectin receptor 2 (soluble Adipo R2) levels for the diagnosis of fatty liver disease in obese and overweight children.MethodsThe study included 51 obese and overweight children between the ages of 6 and 18 years diagnosed with NAFLD using ultrasonography and 20 children without fatty liver disease. Patients whose alanine transaminase level was two times higher than normal (≥80 U/L) were included in the non-alcoholic steatohepatitis (NASH) group.ResultsNASH was observed in 11 (21.6%) of the patients with NAFLD. The incidence of obesity was higher in patients with NASH (80% and 45%, p=0.021). While the adiponectin levels were similar in patients with NAFLD and those without, they were below the normal level in the whole study group. Adiponectin and soluble Adipo R2 levels of patients with NASH were lower than those in patients without NASH; however, this difference was not statistically significant (p=0.064 and p=0.463). Soluble Adipo R2 levels in obese patients with NAFLD were higher than those in obese children without NAFLD (p<0.001).ConclusionSoluble adiponectin receptor 2 level is a noninvasive marker that can be used for the diagnosis of NAFLD in obese children.

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Section: Discussionmentioning

confidence: 99%

Role of Soluble Adiponectin Receptor 2 in Non-Alcoholic Fatty Liver Disease in Children

Aksoy

Artan

Aksoy

et al. 2019

Pediatr Gastroenterol Hepatol Nutr

View full text Add to dashboard Cite

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Adiponectin Resistance in Obesity: Adiponectin Leptin/Insulin Interaction

Engin

2024

Advances in Experimental Medicine and Biology

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The role of adiponectin in gastric cancer

Ming,

Orita,

Shangcheng

et al. 2023

J Cancer Metastasis Treat

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Adiponectin, an adipokine synthesized by adipose tissue, has garnered significant attention in biomedical investigations. Research on its implications suggests that reduced adiponectin levels in the bloodstream might serve as a potential predisposing factor for several types of cancers, including gastric cancer. Although many studies on adiponectin levels in gastric cancer patients have been reported, its predictive role as a biomarker remains controversial. Moreover, the significance of adiponectin receptor expression as a prognostic factor in gastric cancer tissues varies across different research studies, and the precise mechanism by which adiponectin influences the initiation and advancement of gastric cancer remains to be fully elucidated. Furthermore, the anti-inflammatory and postoperative anti-infective effects of adiponectin are worth further investigation. Based on existing studies, it is commonly suggested that in the presence of low adiponectin levels, the stomach might be vulnerable to stimulation or damage from certain carcinogens, promoting gastric cancer development and progression. Considering its complex systemic effects and high serum concentration, adiponectin might serve as a homeostasis regulator and not necessarily as an anti-cancer factor. In this review, we explore the current research available on adiponectin in relation to gastric cancer and discuss its role and corresponding receptors involved in gastric cancer.

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Adiponectin levels may help assess the clinical repercussions of obesity irrespective of body mass index

Abstract: Our data suggest that the distribution of adiponectin above or below a cutoff level may offer additional clinical information over and above that of BMI grouping regarding inflammatory profile, insulin-sensitivity and adiposity.

Cited by 3 publications

References 29 publications

Role of Soluble Adiponectin Receptor 2 in Non-Alcoholic Fatty Liver Disease in Children

Role of Soluble Adiponectin Receptor 2 in Non-Alcoholic Fatty Liver Disease in Children

Adiponectin Resistance in Obesity: Adiponectin Leptin/Insulin Interaction

The role of adiponectin in gastric cancer

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