Adiponectin levels, insulin resistance and their relationship with serum levels of inflammatory cytokines in patients with Behçet’s disease

Şahin, Erdi; Karaman, Göksun; Uslu, Meltem; Karul, Aslıhan; Şendur, Neslihan; Şavk, Ekin

doi:10.1111/j.1468-3083.2011.04318.x

Cited by 12 publications

(18 citation statements)

References 38 publications

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“…Finally, 14 articles met the inclusion criteria for this meta‐analysis (Fig. ) . Three of the eligible studies contained data on two different groups that were treated independently .…”

Section: Resultsmentioning

confidence: 99%

“…Studies on circulating resistin, leptin, adiponectin and visfatin levels in patients with BD compared with healthy controls (HCs) have shown mixed results . Reasons for these disparities include small sample sizes, low statistical power and/or clinical heterogeneity …”

Section: Introductionmentioning

confidence: 99%

“…13 Studies on circulating resistin, leptin, adiponectin and visfatin levels in patients with BD compared with healthy controls (HCs) have shown mixed results. [14][15][16][17][18][19][20][21][22][23][24][25][26][27] Reasons for these disparities include small sample sizes, low statistical power and/or clinical heterogeneity. [28][29][30] To overcome the limitations of individual studies and resolve these inconsistencies, we performed a meta-analysis to determine serum/plasma levels of resistin, leptin, adiponectin and visfatin in patients with BD compared with HCs.…”

Section: Introductionmentioning

confidence: 99%

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Association of circulating resistin, leptin, adiponectin and visfatin levels with Behçet disease: a meta-analysis

Lee

Song

2018

Clin Exp Dermatol

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“…Finally, 14 articles met the inclusion criteria for this meta‐analysis (Fig. ) . Three of the eligible studies contained data on two different groups that were treated independently .…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of circulating resistin, leptin, adiponectin and visfatin levels with Behçet disease: a meta-analysis

Lee

Song

2018

Clin Exp Dermatol

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“…Erythrocyte sedimentation rate9,16,22,24,34,40,43,47,49,59,60,61,63,66,67,68,69,76,77,85,89,94,139,143,177,220,228 and C-reactive protein9,16,24,40,43,47,49,59,60,66,67,76,77,85,89,94,143,177,216,220,228 levels were used as indicators of disease activity. No laboratory measure has been validated as a biomarker of disease activity in BS.…”

Section: Resultsmentioning

confidence: 99%

Outcome Measures Used in Clinical Trials for Behçet Syndrome: A Systematic Review

Hatemi

Merkel²,

Hamuryudan³

et al. 2014

J Rheumatol

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Behçet syndrome (BS) is a multisystem vasculitis that is most active during young adulthood, causing serious disability and significant impairment in quality of life. Differences in the disease course, severity, and organ involvement between patients, depending on the age at presentation and sex, makes it impossible to determine a single management strategy. The diversity and variability in the outcome measures used in clinical trials in BS makes it difficult to compare the results or inform physicians about the best management strategy for individual patients. There is a large unmet need to determine or develop validated outcome measures for use in clinical trials in BS that are acceptable to researchers and regulatory agencies. We conducted a systematic review to describe the outcomes and outcome measures that have been used in clinical trials in BS. This review revealed the diversity and variability in the outcomes and outcome measures and the lack of standard definitions for most outcomes and rarity of validated outcome tools for disease assessment in BS. This systematic literature review will identify domains and candidate instruments for use in a Delphi exercise, the next step in the development of a core set of outcome measures that are properly validated and widely accepted by the collaboration of researchers from many different regions of the world and from different specialties, including rheumatology, ophthalmology, dermatology, gastroenterology, and neurology.

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“…19,20 Further to cytokines, elevated circulating levels of hs-CRP have been reported in patients with chronic SM complications, 21 which is indicative of a heightened burden of systemic inflammation in these patients. Hs-CRP has been documented as one of the most sensitive surrogate markers of systemic inflammation in a number of diseases, including those concerning dermatology such as psoriasis vulgaris, 22 urticaria, 23 Behçet's disease, 24 papillomatosis 25 and uraemic pruritus. 26 There is both human and animal evidence indicating CRP-lowering activity of curcumin.…”

Section: Discussionmentioning

confidence: 99%

A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications

et al. 2012

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Background: Chronic cutaneous complications such as pruritus are among the very frequent complaints of sulphur mustard (SM)-exposed patients. The present trial investigated the impact of curcumin on serum inflammatory biomarkers and their association with pruritus severity and quality of life (QoL). Methods: This was a randomized, double-blind trial among 96 male Iranian veterans (age 37-59 y) who were suffering from chronic SM-induced pruritic skin lesions. Patients were randomly assigned to curcumin (1 g/d, n ¼ 46) or placebo (n ¼ 50) for four weeks. Serum concentrations of interleukins 6 (IL-6) and 8 (IL-8) together with high-sensitivity C-reactive protein (hs-CRP) and calcitonin gene-related peptide (CGRP) were measured at baseline and at the end of the trial. Assessment of pruritus severity was performed using the pruritus score and QoL using the Dermatology Life Quality Index (DLQI). Results: Serum IL-8 and hs-CRP were significantly reduced in both groups but the magnitude of reduction was greater in the curcumin group (P , 0.001). Serum CGRP was only decreased in the curcumin group (P , 0.001). No significant change was observed in serum IL-6. There were significant correlations between CGRP and IL-6 changes (P ¼ 0.011) and between DLQI and IL-8 changes (P ¼ 0.026) in the curcumin group. In the curcumin group, changes in serum IL-8 concentrations were found as the significant predictor of DLQI scores (P ¼ 0.026) but none of the independent variables could predict pruritus scores. Conclusions: Curcumin supplementation effectively mitigates inflammation in patients suffering from chronic SM-induced cutaneous complications. This anti-inflammatory effect might account for the observed pruritus alleviation and QoL improvement by this phytochemical.

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Adiponectin levels, insulin resistance and their relationship with serum levels of inflammatory cytokines in patients with Behçet’s disease

Cited by 12 publications

References 38 publications

Association of circulating resistin, leptin, adiponectin and visfatin levels with Behçet disease: a meta-analysis

Association of circulating resistin, leptin, adiponectin and visfatin levels with Behçet disease: a meta-analysis

Outcome Measures Used in Clinical Trials for Behçet Syndrome: A Systematic Review

A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications

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