2004
DOI: 10.1210/jc.2004-0792
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Adiponectin Levels in the First Two Years of Life in a Prospective Cohort: Relations with Weight Gain, Leptin Levels and Insulin Sensitivity

Abstract: Adiponectin, a novel adipocytokine with insulin sensitizing properties, is inversely related to obesity and insulin resistance in adults. We recently reported large variations in weight gain and insulin sensitivity during the first year in infants born small for gestational age (SGA) or appropriate for gestational age (AGA). We now determined whether adiponectin levels were related to postnatal growth and insulin sensitivity in a prospective cohort followed from birth to two years old (n = 85) (55 female/30 ma… Show more

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Cited by 106 publications
(104 citation statements)
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“…Recent evidence suggests that not only non-esterified fatty acids but other adipokines are directly or indirectly involved in this process, and these may be dysregulated in SGA adipose tissue [24]. In this prospective cohort study, we recently showed that levels of the adipokine adiponectin declined from the first to the second year of life, and the rate of fall was related to age and greater weight gain in SGA infants [25]. In that analysis, adiponectin levels were unrelated to the degree of insulin resistance.…”
Section: Discussionmentioning
confidence: 74%
“…Recent evidence suggests that not only non-esterified fatty acids but other adipokines are directly or indirectly involved in this process, and these may be dysregulated in SGA adipose tissue [24]. In this prospective cohort study, we recently showed that levels of the adipokine adiponectin declined from the first to the second year of life, and the rate of fall was related to age and greater weight gain in SGA infants [25]. In that analysis, adiponectin levels were unrelated to the degree of insulin resistance.…”
Section: Discussionmentioning
confidence: 74%
“…Treatment of Lep ob /Lep ob neonates with exogenous leptin rescues the development of ARH projections and leptin promotes neurite outgrowth from ARH neurons in vitro. It is well established that SGA children are hypoleptinemic and cord blood leptin concentrations are significantly diminished [147] . These children go on to develop obesity and leptin resistance in adult life and this can be mimicked experimentally in the rat [47] .…”
Section: Critical Windows Of Development and Avenues For Interventionmentioning
confidence: 99%
“…Adiponectin levels in cord blood are significantly higher than adult concentrations, and are positively correlated with gestational age (14) and birth weight (15). Plasma adiponectin decreases physiologically between the first and second years of life (16).…”
Section: Introductionmentioning
confidence: 99%