Adiponectin Interactions in Bone and Cartilage Biology and Disease

Ruscica, Massimiliano; Steffani, Liliana; Magni, Paolo

doi:10.1016/b978-0-12-398313-8.00012-9

Cited by 16 publications

(25 citation statements)

References 108 publications

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“…Adiponectin is rich in the circulation and has been shown to be involved in body metabolism and the immune response (5,6). Recently, adiponectin has been implicated in cartilage and bone diseases (24–26). Several studies have reported elevated adiponectin levels in individuals with RA (9,27–29).…”

Section: Discussionmentioning

confidence: 99%

Association of adiponectin protein and ADIPOQ gene variants with lumbar disc degeneration

Khabour

Abu-Rumeh

Al-Jarrah

et al. 2014

Experimental and Therapeutic Medicine

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Lumbar disc degeneration (LDD) is a widespread public health problem that may lead to disability and loss of productivity. Adiponectin is an adipokine secreted by adipose tissue and has been shown to be involved in cartilage homeostasis. In the present study, the association between the rs266729 (−11377C/G) and rs2241766 (45T/G) single nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) and LDD was investigated. In addition, the correlation between the plasma adiponectin level and LDD was examined. A total of 289 subjects, 168 patients with LDD and 122 healthy individuals, were recruited in the study. All subjects were genotyped for rs266729 and rs2241766 SNPs using polymerase chain reaction-restriction fragment length polymorphism. Circulating levels of adiponectin protein were measured using the ELISA technique. A strong association was found between adiponectin level and LDD (P<0.01), where high levels of adiponectin were found in patients compared with healthy controls. The increase in adiponectin level was not affected by gender. However, no significant differences were found in the genotype distribution or allelic frequency of the two examined polymorphisms between patients with LDD and healthy controls (P>0.05). In conclusion, adiponectin appears to be elevated in patients with LDD. The rs266729 and rs2241766 SNPs in the ADIPOQ gene are not associated with LDD.

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Section: Discussionmentioning

confidence: 99%

Association of adiponectin protein and ADIPOQ gene variants with lumbar disc degeneration

Khabour

Abu-Rumeh

Al-Jarrah

et al. 2014

Experimental and Therapeutic Medicine

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“…In addition, adiponectin is able to induce motility of prostate cancer and chondrosarcoma cells [27,28]. Moreover, adiponectin is closely associated with bone remodelling and bone pathologies [29,30]. Serum adiponectin levels have shown to be inversely associated with bone mineral density [31].…”

Section: Discussionmentioning

confidence: 99%

Transcriptome analysis of osteosarcoma identifies suppression of wnt pathway and up-regulation of adiponectin as potential biomarker

Märtson¹,

Kõks²,

Reimann³

et al. 2013

Genomics Discov

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Osteosarcoma (OS) is primary malignant bone tumour with complicated early diagnosis. There are no specific markers currently available for predicting the prognosis and chemosensitivity of OS. In present study we performed transcriptome profiling of single patient tumour tissue with RNA-seq technology. We analysed surgically removed sarcoma sample from single 16 years old male patient. Transciptome analysis was done with RNA-seq technology, bioinformatics with Lifescope and R Bioconductor. Validation experiments were done with quantitative real-time PCR (QRTPCR). After quality and coverage filtering, RNA-seq experiment resulted 29,311,899 mapped reads for sarcoma and 22,099,159 mapped reads for normal bone tissue. 65 genes were differentially expressed with FDR corrected statistical significance below 0.05. Seven genes were down-regulated and 58 genes were up-regulated in sarcoma. The most highly up-regulated gene in sarcoma was adiponectin, ADIPOQ (with adjusted p-value 5.5E-07, log2 fold change was 7.9). Many of the genes we found are related to the adipose tissue metabolism (ADIPOQ, PLIN1, FABP4) and to the Wnt signalling suppression (WIF1, SOST). We also found novel fusion transcript between the genes LMTK2 and ZSWIM5. LMTK2 is lemur tyrosine kinase 2, and it has been shown to be involved in NGF-TrkA signalling. Interestingly, studies support the involvement of LMTK2 in development of prostate cancer. ZSWIM5 is zinc finger SWIM domain protein 5 and its function is not known. Immunohistochemical analysis confirmed positive staining for adiponectin in osteosarcoma. This paper is a good illustration how transcriptome analysis can find new biomarkers and targets for complex diseases.

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“…Adiponectin was positively associated with total OC [87,88] and BAP [89] in postmenopausal women and in Chinese men [90], but in other studies no correlation with any of bone formation or bone resorption markers was found [45,91]. Several clinical studies have shown an inverse relationship between circulating adiponectin and BMD independent of gender and menopausal status, and some reviewers concluded that adiponectin may be a negative regulator of bone mass [82,[92][93][94], while other emphasized that the data on this association are inconsistent [95]. It is also uncertain whether resistin is related to bone turnover markers.…”

Section: Adipokines and Markers Of Hepatic Mineral And Bone Metabolismmentioning

confidence: 99%

Associations Between Liver Function, Bone Turnover Biomarkers and Adipokines in Older Patients With Hip Fracture

Fisher

2014

J Endocrinol Metab

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Adiponectin Interactions in Bone and Cartilage Biology and Disease

Cited by 16 publications

References 108 publications

Association of adiponectin protein and ADIPOQ gene variants with lumbar disc degeneration

Association of adiponectin protein and ADIPOQ gene variants with lumbar disc degeneration

Transcriptome analysis of osteosarcoma identifies suppression of wnt pathway and up-regulation of adiponectin as potential biomarker

Associations Between Liver Function, Bone Turnover Biomarkers and Adipokines in Older Patients With Hip Fracture

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